Association of coronary artery disease and chronic kidney disease in Lebanese population

Aline Milane, Georges Khazen, Nabil Zeineddine, Mazen Amro, Leila Masri, Michella Ghassibe-Sabbagh, Sonia Youhanna, Angelique K. Salloum, Marc Haber, Daniel E. Platt, Jean Baptiste Cazier, Raed Othman, Samer Kabbani, Hana Sbeite, Youssef Chami, Elie Chammas, Hamid el Bayeh, Dominique Gauguier, Antoine B. Abchee, Pierre Zalloua*Antoine Barbari

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background: More evidence is emerging on the strong association between chronic kidney disease (CKD) and cardiovascular disease. We assessed the relationship between coronary artery disease (CAD) and renal dysfunction level (RDL) in a group of Lebanese patients. Methods: A total of 1268 patients undergoing cardiac catheterization were sequentially enrolled in a multicenter cross sectional study. Angiograms were reviewed and CAD severity scores (CADSS) were determined. Estimated glomerular filtration rate (eGFR) was calculated and clinical and laboratory data were obtained. CKD was defined as eGFR < 60 ml/min. Logistic regression model was performed using multivariate analysis including all traditional risk factors associated with both diseases. ANOVA and the Tukeytestswere used to compare subgroups of patients and to assess the impact of each disease on the severity of the other. Results: Among the 82% patients who exhibited variable degrees of CAD, 20.6% had an eGFR < 60 ml/min. Logistic regression analysis revealed a bidirectional independent association between CAD and CKD with an OR = 2.01 (P < 0.01) and an OR = 1.99 (P < 0.01) for CAD and CKD frequencies, respectively. We observed a steady increase in the CADSS mean as eGFR declined and a progressive reduction in renal function with the worsening of CAD (P < 0.05). This correlation remained highly significant despite considerable inter-patient variability and was at its highest at the most advanced stages of both diseases. Conclusions: Our results show a strong, independent and graded bidirectional relationship between CAD severity and RDL. We propose to add CAD to the list of risk factors for the development and progression of CKD.

Original languageEnglish
Pages (from-to)15866-15877
Number of pages13
JournalInternational Journal of Clinical and Experimental Medicine
Issue number9
Early online date15 Sept 2015
Publication statusPublished - 30 Sept 2015


  • Chronic kidney disease
  • Coronary artery disease
  • Lebanese population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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