Abstract
Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.
Original language | English |
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Pages (from-to) | 4904-4907 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 50 |
Issue number | 38 |
Early online date | 25 Mar 2014 |
DOIs | |
Publication status | Published - 18 May 2014 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry