Antiviral mechanism change of poly(styrene sulfonate) through gold nanoparticle coating†

Lorraine M. Bhebhe; Jungyeon Kim; Luke M. Jones; Elana H. Super; Samuel T. Jones

doi:10.1039/d3py01217d

Antiviral mechanism change of poly(styrene sulfonate) through gold nanoparticle coating†

Lorraine M. Bhebhe, Jungyeon Kim, Luke M. Jones, Elana H. Super, Samuel T. Jones^*

^*Corresponding author for this work

Chemistry

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Abstract

Viruses are pathogens capable of causing serious global health problems and therefore the development of interventions against them is of paramount importance. One strategy towards designing broad-spectrum antivirals is through the mimicking of sulfonated glycopolymers on the cell surface so that the virion/cell interaction is inhibited by the antiviral material. A number of natural and synthetic polymers have been investigated, however, most show a virustatic mechanism, which is reversible and non-destructive. Herein we present a facile route to virucidal materials by attaching a previously known virustatic polymer, poly(styrene sulfonate), onto gold nanoparticles. We show that it is possible to alter the polymer's mode of action whilst maintaining its low IC₅₀ by changing the macromolecular architecture.

Original language	English
Pages (from-to)	945-951
Number of pages	7
Journal	Polymer Chemistry
Volume	15
Issue number	10
Early online date	7 Feb 2024
DOIs	https://doi.org/10.1039/d3py01217d
Publication status	E-pub ahead of print - 7 Feb 2024

Bibliographical note

Acknowledgments:
L. M. J. acknowledges support from Innovate UK (IUK Project Reference 82583) This work was also supported by the Henry Royce Institute for Advanced Materials, funded through EPSRC grants EP/R00661X/1, EP/S019367/1, EP/P025021/1 and EP/P025498/1. With thanks to Lauren J. Batt and Ayesha Patel for data collection associated with PSS-AuNP UV-vis data.

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title = "Antiviral mechanism change of poly(styrene sulfonate) through gold nanoparticle coating†",

abstract = "Viruses are pathogens capable of causing serious global health problems and therefore the development of interventions against them is of paramount importance. One strategy towards designing broad-spectrum antivirals is through the mimicking of sulfonated glycopolymers on the cell surface so that the virion/cell interaction is inhibited by the antiviral material. A number of natural and synthetic polymers have been investigated, however, most show a virustatic mechanism, which is reversible and non-destructive. Herein we present a facile route to virucidal materials by attaching a previously known virustatic polymer, poly(styrene sulfonate), onto gold nanoparticles. We show that it is possible to alter the polymer's mode of action whilst maintaining its low IC50 by changing the macromolecular architecture.",

author = "Bhebhe, {Lorraine M.} and Jungyeon Kim and Jones, {Luke M.} and Super, {Elana H.} and Jones, {Samuel T.}",

note = "Acknowledgments: L. M. J. acknowledges support from Innovate UK (IUK Project Reference 82583) This work was also supported by the Henry Royce Institute for Advanced Materials, funded through EPSRC grants EP/R00661X/1, EP/S019367/1, EP/P025021/1 and EP/P025498/1. With thanks to Lauren J. Batt and Ayesha Patel for data collection associated with PSS-AuNP UV-vis data.",

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AU - Kim, Jungyeon

AU - Jones, Luke M.

AU - Super, Elana H.

AU - Jones, Samuel T.

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AB - Viruses are pathogens capable of causing serious global health problems and therefore the development of interventions against them is of paramount importance. One strategy towards designing broad-spectrum antivirals is through the mimicking of sulfonated glycopolymers on the cell surface so that the virion/cell interaction is inhibited by the antiviral material. A number of natural and synthetic polymers have been investigated, however, most show a virustatic mechanism, which is reversible and non-destructive. Herein we present a facile route to virucidal materials by attaching a previously known virustatic polymer, poly(styrene sulfonate), onto gold nanoparticles. We show that it is possible to alter the polymer's mode of action whilst maintaining its low IC50 by changing the macromolecular architecture.

U2 - 10.1039/d3py01217d

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JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 10

ER -

Antiviral mechanism change of poly(styrene sulfonate) through gold nanoparticle coating†

Abstract

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