Abstract
Viruses are pathogens capable of causing serious global health problems and therefore the development of interventions against them is of paramount importance. One strategy towards designing broad-spectrum antivirals is through the mimicking of sulfonated glycopolymers on the cell surface so that the virion/cell interaction is inhibited by the antiviral material. A number of natural and synthetic polymers have been investigated, however, most show a virustatic mechanism, which is reversible and non-destructive. Herein we present a facile route to virucidal materials by attaching a previously known virustatic polymer, poly(styrene sulfonate), onto gold nanoparticles. We show that it is possible to alter the polymer's mode of action whilst maintaining its low IC50 by changing the macromolecular architecture.
| Original language | English |
|---|---|
| Pages (from-to) | 945-951 |
| Number of pages | 7 |
| Journal | Polymer Chemistry |
| Volume | 15 |
| Issue number | 10 |
| Early online date | 7 Feb 2024 |
| DOIs | |
| Publication status | E-pub ahead of print - 7 Feb 2024 |
Bibliographical note
Acknowledgments:L. M. J. acknowledges support from Innovate UK (IUK Project Reference 82583) This work was also supported by the Henry Royce Institute for Advanced Materials, funded through EPSRC grants EP/R00661X/1, EP/S019367/1, EP/P025021/1 and EP/P025498/1. With thanks to Lauren J. Batt and Ayesha Patel for data collection associated with PSS-AuNP UV-vis data.