Antimycobacterial activity and mechanism of action of NAS-91

P Gratraud; N Surolia; Gurdyal Besra; A Surolia; L Kremer

doi:10.1128/AAC.00968-07

Antimycobacterial activity and mechanism of action of NAS-91

P Gratraud, N Surolia, Gurdyal Besra, A Surolia, L Kremer

Biosciences

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19 Citations (Scopus)

Abstract

The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.

Original language	English
Pages (from-to)	1162-1166
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	3
Early online date	17 Dec 2007
DOIs	https://doi.org/10.1128/AAC.00968-07
Publication status	Published - 1 Mar 2008

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10.1128/AAC.00968-07

MAGPIE Project: The Structure and Assembly of the Mycobacterial Cell Envelope
Besra, D. (Principal Investigator), Lammas, T. (Co-Investigator) & Minnikin, D. (Co-Investigator)
Medical Research Council
1/02/06 → 31/01/11
Project: Research Councils

Cite this

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title = "Antimycobacterial activity and mechanism of action of NAS-91",

abstract = "The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.",

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AU - Surolia, N

AU - Besra, Gurdyal

AU - Surolia, A

AU - Kremer, L

PY - 2008/3/1

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N2 - The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.

AB - The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.

U2 - 10.1128/AAC.00968-07

DO - 10.1128/AAC.00968-07

M3 - Article

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JO - Antimicrobial Agents and Chemotherapy

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Antimycobacterial activity and mechanism of action of NAS-91

Abstract

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Projects

MAGPIE Project: The Structure and Assembly of the Mycobacterial Cell Envelope

Cite this