ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

MJ Greenway; PM Anderson; C Russ; S Ennis; S Cashman; C Donaghy; V Patterson; R Swingler; D Kieran; J Prehn; Karen Morrison; A Green; KR Acharya; RH Brown Jr; O Hardiman

doi:10.1038/ng1742

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

MJ Greenway, PM Anderson, C Russ, S Ennis, S Cashman, C Donaghy, V Patterson, R Swingler, D Kieran, J Prehn, Karen Morrison, A Green, KR Acharya, RH Brown Jr, O Hardiman

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Abstract

We recently identified angiogenin (ANG) as a candidate susceptibility gene for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by adult-onset loss of motor neurons. We now report the finding of seven missense mutations in 15 individuals, of whom four had familial ALS and 11 apparently 'sporadic' ALS. Our findings provide further evidence that variations in hypoxia-inducible genes have an important role in motor neuron degeneration.

Original language	English
Pages (from-to)	411-413
Number of pages	3
Journal	Nature Genetics
Volume	38
Issue number	4
DOIs	https://doi.org/10.1038/ng1742
Publication status	Published - 26 Feb 2006

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title = "ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis",

abstract = "We recently identified angiogenin (ANG) as a candidate susceptibility gene for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by adult-onset loss of motor neurons. We now report the finding of seven missense mutations in 15 individuals, of whom four had familial ALS and 11 apparently 'sporadic' ALS. Our findings provide further evidence that variations in hypoxia-inducible genes have an important role in motor neuron degeneration.",

author = "MJ Greenway and PM Anderson and C Russ and S Ennis and S Cashman and C Donaghy and V Patterson and R Swingler and D Kieran and J Prehn and Karen Morrison and A Green and KR Acharya and {Brown Jr}, RH and O Hardiman",

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T1 - ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

AU - Greenway, MJ

AU - Anderson, PM

AU - Russ, C

AU - Ennis, S

AU - Cashman, S

AU - Donaghy, C

AU - Patterson, V

AU - Swingler, R

AU - Kieran, D

AU - Prehn, J

AU - Morrison, Karen

AU - Green, A

AU - Acharya, KR

AU - Brown Jr, RH

AU - Hardiman, O

PY - 2006/2/26

Y1 - 2006/2/26

N2 - We recently identified angiogenin (ANG) as a candidate susceptibility gene for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by adult-onset loss of motor neurons. We now report the finding of seven missense mutations in 15 individuals, of whom four had familial ALS and 11 apparently 'sporadic' ALS. Our findings provide further evidence that variations in hypoxia-inducible genes have an important role in motor neuron degeneration.

AB - We recently identified angiogenin (ANG) as a candidate susceptibility gene for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by adult-onset loss of motor neurons. We now report the finding of seven missense mutations in 15 individuals, of whom four had familial ALS and 11 apparently 'sporadic' ALS. Our findings provide further evidence that variations in hypoxia-inducible genes have an important role in motor neuron degeneration.

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U2 - 10.1038/ng1742

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SP - 411

EP - 413

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

Abstract

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