An unusual case of three concomitant primary solid cancers with unique histopathological characteristics

Mohamed Shatila; Janos Balega; Maninder S Kalkat; Akshay J Patel; Ijaz Ahmad

doi:10.1016/j.ijscr.2023.109080

An unusual case of three concomitant primary solid cancers with unique histopathological characteristics

Mohamed Shatila, Janos Balega, Maninder S Kalkat, Akshay J Patel^*, Ijaz Ahmad

^*Corresponding author for this work

Immunology and Immunotherapy

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Abstract

INTRODUCTION AND IMPORTANCE: Struma Ovarii is a rare type of monodermal teratoma with at least 50 % of its mass being thyroid tissue. They make up <1 % of all ovarian tumours and 3 to 5 % of all ovarian teratomas. These tumours are usually benign but malignant transformation is seen in <5 % of cases.

CASE PRESENTATION: We present the case of a 45-year-old lady with three synchronous primary cancers on a background of Struma Ovarii; primary lung adenocarcinoma, papillary thyroid carcinoma and ovarian teratoma. Over the course of 18 months, this lady underwent full pelvic clearance of malignant Struma Ovarii and lymph nodes, total thyroidectomy, and an anatomical lung resection.

CLINICAL DISCUSSION: This case represents an incredibly rare condition of Struma Ovarii for which there is no firm management consensus. Furthermore, the uniqueness of three separate primaries has to the best of our knowledge not previously been reported in the literature.

CONCLUSION: This reinforces the notion that in select patients, radical management with curative intent is entirely possible but requires complete multi-disciplinary and multi-modal sub-specialty collaboration.

Original language	English
Article number	109080
Journal	International journal of surgery case reports
Volume	113
Early online date	20 Nov 2023
DOIs	https://doi.org/10.1016/j.ijscr.2023.109080
Publication status	Published - Dec 2023

Bibliographical note

Keywords

Ovarian teratoma
Struma ovarii (SO)
Papillary thyroid carcinoma (PTC)
Lung adenocarcinoma
Non-small cell lung cancer (NSCLC)
Radioactive iodine (RAI)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "An unusual case of three concomitant primary solid cancers with unique histopathological characteristics",

abstract = "INTRODUCTION AND IMPORTANCE: Struma Ovarii is a rare type of monodermal teratoma with at least 50 % of its mass being thyroid tissue. They make up <1 % of all ovarian tumours and 3 to 5 % of all ovarian teratomas. These tumours are usually benign but malignant transformation is seen in <5 % of cases.CASE PRESENTATION: We present the case of a 45-year-old lady with three synchronous primary cancers on a background of Struma Ovarii; primary lung adenocarcinoma, papillary thyroid carcinoma and ovarian teratoma. Over the course of 18 months, this lady underwent full pelvic clearance of malignant Struma Ovarii and lymph nodes, total thyroidectomy, and an anatomical lung resection.CLINICAL DISCUSSION: This case represents an incredibly rare condition of Struma Ovarii for which there is no firm management consensus. Furthermore, the uniqueness of three separate primaries has to the best of our knowledge not previously been reported in the literature.CONCLUSION: This reinforces the notion that in select patients, radical management with curative intent is entirely possible but requires complete multi-disciplinary and multi-modal sub-specialty collaboration.",

keywords = "Ovarian teratoma, Struma ovarii (SO), Papillary thyroid carcinoma (PTC), Lung adenocarcinoma, Non-small cell lung cancer (NSCLC), Radioactive iodine (RAI)",

author = "Mohamed Shatila and Janos Balega and Kalkat, {Maninder S} and Patel, {Akshay J} and Ijaz Ahmad",

note = "Copyright {\textcopyright} 2023 The Authors. ",

year = "2023",

month = dec,

doi = "10.1016/j.ijscr.2023.109080",

language = "English",

volume = "113",

journal = "International journal of surgery case reports",

issn = "2210-2612",

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AU - Shatila, Mohamed

AU - Balega, Janos

AU - Kalkat, Maninder S

AU - Patel, Akshay J

AU - Ahmad, Ijaz

PY - 2023/12

Y1 - 2023/12

N2 - INTRODUCTION AND IMPORTANCE: Struma Ovarii is a rare type of monodermal teratoma with at least 50 % of its mass being thyroid tissue. They make up <1 % of all ovarian tumours and 3 to 5 % of all ovarian teratomas. These tumours are usually benign but malignant transformation is seen in <5 % of cases.CASE PRESENTATION: We present the case of a 45-year-old lady with three synchronous primary cancers on a background of Struma Ovarii; primary lung adenocarcinoma, papillary thyroid carcinoma and ovarian teratoma. Over the course of 18 months, this lady underwent full pelvic clearance of malignant Struma Ovarii and lymph nodes, total thyroidectomy, and an anatomical lung resection.CLINICAL DISCUSSION: This case represents an incredibly rare condition of Struma Ovarii for which there is no firm management consensus. Furthermore, the uniqueness of three separate primaries has to the best of our knowledge not previously been reported in the literature.CONCLUSION: This reinforces the notion that in select patients, radical management with curative intent is entirely possible but requires complete multi-disciplinary and multi-modal sub-specialty collaboration.

AB - INTRODUCTION AND IMPORTANCE: Struma Ovarii is a rare type of monodermal teratoma with at least 50 % of its mass being thyroid tissue. They make up <1 % of all ovarian tumours and 3 to 5 % of all ovarian teratomas. These tumours are usually benign but malignant transformation is seen in <5 % of cases.CASE PRESENTATION: We present the case of a 45-year-old lady with three synchronous primary cancers on a background of Struma Ovarii; primary lung adenocarcinoma, papillary thyroid carcinoma and ovarian teratoma. Over the course of 18 months, this lady underwent full pelvic clearance of malignant Struma Ovarii and lymph nodes, total thyroidectomy, and an anatomical lung resection.CLINICAL DISCUSSION: This case represents an incredibly rare condition of Struma Ovarii for which there is no firm management consensus. Furthermore, the uniqueness of three separate primaries has to the best of our knowledge not previously been reported in the literature.CONCLUSION: This reinforces the notion that in select patients, radical management with curative intent is entirely possible but requires complete multi-disciplinary and multi-modal sub-specialty collaboration.

KW - Ovarian teratoma

KW - Struma ovarii (SO)

KW - Papillary thyroid carcinoma (PTC)

KW - Lung adenocarcinoma

KW - Non-small cell lung cancer (NSCLC)

KW - Radioactive iodine (RAI)

U2 - 10.1016/j.ijscr.2023.109080

DO - 10.1016/j.ijscr.2023.109080

M3 - Article

C2 - 37995507

SN - 2210-2612

VL - 113

JO - International journal of surgery case reports

JF - International journal of surgery case reports

M1 - 109080

ER -

An unusual case of three concomitant primary solid cancers with unique histopathological characteristics

Abstract

Bibliographical note

Keywords

UN SDGs

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