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Abstract
Due to limitations in available paediatric stents for treatment of aortic coarctation, adult stents are often used off-label resulting in less than optimal outcomes. The increasingly widespread use of CT and/or MR imaging for pre-surgical assessment, and the emergence of additive manufacturing processes such as 3D printing, could enable bespoke devices to be produced efficiently and cost-effectively. However, 3D printed metallic stents need to be self-supporting leading to limitations in their design. In this study, we investigate the use of etching to overcome these design constraints and improve stent surface finish. Furthermore, using a combination of experimental bench testing and finite element (FE) methods we investigate how etching influences stent performance. Then using an inverse finite element approach the material properties of the printed and etched stents were calibrated and compared. We show that without etching the titanium stents, the inverse FE approach underestimates the stiffness of the as-built stent (E = 33.89 GPa) when compared to an average of 76.84 GPa for the etched stent designs. Finally, using patient-specific finite element models the different stents’ performance were tested to assess patient outcomes and lumen gain and vessel stresses were found to be strongly influenced by the stent design and postprocessing. Within this study, etching is confirmed as a means to create open-cell stent designs whilst still conforming to additive manufacturing ‘rules’ and concomitantly improving stent surface finish. Additionally, the feasibility of using an in-vivo imaging-to-product development pipeline is demonstrated that enables patient-specific stents to be produced for varying anatomies to achieve optimum device performance.
Original language | English |
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Article number | 105388 |
Number of pages | 11 |
Journal | Journal of the Mechanical Behavior of Biomedical Materials |
Volume | 134 |
Early online date | 30 Jul 2022 |
DOIs | |
Publication status | Published - Oct 2022 |
Bibliographical note
Funding Information:This study was funded National Children's Research Centre , Crumlin (Grant No. G/19/3 ), an Irish Research Council Government of Ireland Postdoctoral Fellowship (2019) ( GOIPD/2019/222 ) and from research supported in part by a research grant from Science Foundation Ireland (SFI) under the grant number 12/RC/2278_2 . Prof. Moataz M. Attallah and Dr Parastoo Jamshidi acknowledge the support from Engineering and Physical Science Research Council (EPSRC) (Grant Number: EP/R001650/1 ; Title: Smart peripheral stents for the lower extremity–design, manufacturing and evaluation).
Publisher Copyright:
© 2022 The Authors
Keywords
- Additive manufacturing
- Cardiovascular stents
- Etching
- Finite element modelling
- Patient-specific
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Mechanics of Materials
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Dive into the research topics of 'An investigation into patient-specific 3D printed titanium stents and the use of etching to overcome Selective Laser Melting design constraints'. Together they form a unique fingerprint.Projects
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Smart peripheral stents for the lower extremity: design, manufacturing, and evaluation
Engineering & Physical Science Research Council
1/12/17 → 30/11/21
Project: Research Councils