Abstract
Eight patients with paraneoplastic cerebellar degeneration (PCD) and anti-Yo antibodies were investigated to determine whether there is any association between cytotoxic T lymphocyte (CTL) responses reactive with two previously defined Yo-derived, HLA-A2.1 restricted epitopes (cdr2-1 and cdr2-2) and the presence of tumour-infiltrating CD8+ CTLs. cdr2-1 and cdr2-2-specific CTL responses could not be detected in 5 HLA-A2.1(+) patients in an ex vivo interferon-gamma ELISPOT assay and only 2/9 tumour sections contained CD8(+) intratumoural lymphocytes suggesting a very limited role for CTL-mediated tumour immunity in this patient group, all of whom had evidence of widespread malignancy at the time of diagnosis and/or death.
Original language | English |
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Pages (from-to) | 98-106 |
Number of pages | 9 |
Journal | Journal of Neuroimmunology |
Volume | 150 |
DOIs | |
Publication status | Published - 1 Jan 2004 |
Keywords
- interferon-gamma
- elispot
- cytotoxic T lymphocyte
- paraneoplastic