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Abstract
Ageing is inherent to all human beings, yet why we age remains a hotly contested topic. Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of one or more forms of molecular damage. Here, I propose that we age not because of inevitable damage to the hardware but rather because of intrinsic design flaws in the software, defined as the DNA code that orchestrates how a single cell develops into an adult organism. As the developmental software runs, its sequence of events is reflected in shifting cellular epigenetic states. Overall, I suggest that to understand ageing we need to decode our software and the flow of epigenetic information throughout the life course.
Original language | English |
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Article number | 51 |
Journal | Genome Biology |
Volume | 24 |
Issue number | 1 |
DOIs | |
Publication status | Published - 28 Mar 2023 |
Bibliographical note
© 2023. The Author(s).Keywords
- Humans
- Longevity/genetics
- Software Design
- Aging/genetics
- Selection, Genetic
- Review
- Longevity
- Genome
- Antagonistic pleiotropy
- Information theory
- Programmed ageing
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GeneFriends: A gene and transcript co-expression resource
Lourenco Rocha De Magalhaes, J. P.
1/09/22 → 28/08/24
Project: Research