Adrenaline activation of the carotid body: key to CO2 and pH homeostasis in hypoglycaemia and potential pathological implications in cardiovascular disease

Andrew Holmes, Clare Ray, Emma Thompson, Ziyad Alshehri, Andrew Coney, Prem Kumar

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
194 Downloads (Pure)

Abstract

Ventilatory and neuroendocrine counter-regulatory responses during hypoglycaemia are essential in order to maintain glycolysis and prevent rises in PaCO2 leading to systemic acidosis. The mammalian carotid body has emerged as an important driver of hyperpnoea and glucoregulation in hypoglycaemia. However, the adequate stimulus for CB stimulation in hypoglycaemia has remained controversial for over a decade. The recent finding that adrenaline is a physiological activator of CB in hypoglycaemia raises the intriguing possibility that CB stimulation and hyperpnoea may be necessary to maintain pH in other adrenaline-related hypermetabolic states such as exercise. This review will therefore focus on 1) The important functional contribution of the CB in the counter-regulatory and ventilatory response to hypoglycaemia, 2) the proposed mechanisms that cause CB stimulation in hypoglycaemia including hormonal activation by adrenaline and direct low glucose sensing and 3) the possible pathological consequences of repetitive CB activation by adrenaline that could potentially be targeted to reduce CB-mediated cardiovascular disease.
Original languageEnglish
JournalRespiratory physiology & neurobiology
Early online date25 May 2018
DOIs
Publication statusE-pub ahead of print - 25 May 2018

Keywords

  • Adrenaline
  • carotid body
  • CO2
  • Hypercapnia
  • glucose
  • hypoglycaemia
  • Hypoxia

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