Adding a transcription-coupled repair pathway

Marco Saponaro

doi:10.1038/s41556-024-01399-7

Adding a transcription-coupled repair pathway

Marco Saponaro^*

^*Corresponding author for this work

Cancer and Genomic Sciences

Research output: Contribution to journal › Comment/debate

Abstract

When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading to excision of the damaged site and DNA synthesis to fill the gap. Three new studies show that, for aldehyde-induced DNA crosslinks, repair is activated by the same factors, but without base excision and gap filling.

Original language	English
Pages (from-to)	670-671
Number of pages	2
Journal	Nature Cell Biology
Volume	26
Issue number	5
Early online date	10 Apr 2024
DOIs	https://doi.org/10.1038/s41556-024-01399-7
Publication status	Published - May 2024

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Publisher Copyright:
© Springer Nature Limited 2024.

ASJC Scopus subject areas

Cell Biology

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Cite this

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title = "Adding a transcription-coupled repair pathway",

abstract = "When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading to excision of the damaged site and DNA synthesis to fill the gap. Three new studies show that, for aldehyde-induced DNA crosslinks, repair is activated by the same factors, but without base excision and gap filling.",

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AB - When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading to excision of the damaged site and DNA synthesis to fill the gap. Three new studies show that, for aldehyde-induced DNA crosslinks, repair is activated by the same factors, but without base excision and gap filling.

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Adding a transcription-coupled repair pathway

Abstract

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