Activation of the NO-cGMP signalling pathway depresses hippocampal synaptic transmission through an adenosine receptor-dependent mechanism

M. R. Broome, G. L. Collingridge, A. J. Irving

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Activation of the NO-cGMP pathway or adenosine receptors depresses reversibly synaptic transmission in the hippocampus. Here we demonstrate, using the selective A1 receptor antagonist DPCPX, a convergence in the mechanisms of action of the NO donor SNAP, the cGMP phosphodiesterase inhibitor zaprinast and adenosine.

Original languageEnglish
Pages (from-to)1511-1513
Number of pages3
JournalNeuropharmacology
Volume33
Issue number11
DOIs
Publication statusPublished - Nov 1994

Keywords

  • adenosine
  • cGMP
  • DPCPX
  • Nitric oxide
  • SNAP
  • zaprinast

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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