Abnormal P300 in people with high risk of developing psychosis

Elvira Bramon; Madiha Shaikh; Matthew Broome; Julia Lappin; Daniel Bergé; Fern Day; James Woolley; Paul Tabraham; Mercè Madre; Louise Johns; Oliver Howes; Lucia Valmaggia; Víctor Pérez; Pak Sham; Robin M. Murray; Philip McGuire

doi:10.1016/j.neuroimage.2007.12.038

Abnormal P300 in people with high risk of developing psychosis

Elvira Bramon^*, Madiha Shaikh, Matthew Broome, Julia Lappin, Daniel Bergé, Fern Day, James Woolley, Paul Tabraham, Mercè Madre, Louise Johns, Oliver Howes, Lucia Valmaggia, Víctor Pérez, Pak Sham, Robin M. Murray, Philip McGuire

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk.

Original language	English
Pages (from-to)	553-560
Number of pages	8
Journal	NeuroImage
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.neuroimage.2007.12.038
Publication status	Published - Jun 2008

Bibliographical note

Funding Information:
This study was supported by the following charities: The Wellcome Trust, The Schizophrenia Research Fund and the National Alliance for Research on Schizophrenia and Depression, The Psychiatry Research Trust and the British Medical Association. E. Bramon was supported by a fellowship from The Wellcome Trust, a NARSAD young investigator award and a post-doctoral fellowship from the UK's Department of Health. M. Shaikh is sponsored by the Psychiatry Research Trust. Our special thanks go to all the people who volunteered to take part in this research.

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2007.12.038

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title = "Abnormal P300 in people with high risk of developing psychosis",

abstract = "Background: Individuals with an {"}at-risk mental state{"} (or {"}prodromal{"} symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk.",

author = "Elvira Bramon and Madiha Shaikh and Matthew Broome and Julia Lappin and Daniel Berg{\'e} and Fern Day and James Woolley and Paul Tabraham and Merc{\`e} Madre and Louise Johns and Oliver Howes and Lucia Valmaggia and V{\'i}ctor P{\'e}rez and Pak Sham and Murray, {Robin M.} and Philip McGuire",

note = "Funding Information: This study was supported by the following charities: The Wellcome Trust, The Schizophrenia Research Fund and the National Alliance for Research on Schizophrenia and Depression, The Psychiatry Research Trust and the British Medical Association. E. Bramon was supported by a fellowship from The Wellcome Trust, a NARSAD young investigator award and a post-doctoral fellowship from the UK's Department of Health. M. Shaikh is sponsored by the Psychiatry Research Trust. Our special thanks go to all the people who volunteered to take part in this research.",

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doi = "10.1016/j.neuroimage.2007.12.038",

language = "English",

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T1 - Abnormal P300 in people with high risk of developing psychosis

AU - Bramon, Elvira

AU - Shaikh, Madiha

AU - Broome, Matthew

AU - Lappin, Julia

AU - Bergé, Daniel

AU - Day, Fern

AU - Woolley, James

AU - Tabraham, Paul

AU - Madre, Mercè

AU - Johns, Louise

AU - Howes, Oliver

AU - Valmaggia, Lucia

AU - Pérez, Víctor

AU - Sham, Pak

AU - Murray, Robin M.

AU - McGuire, Philip

N1 - Funding Information: This study was supported by the following charities: The Wellcome Trust, The Schizophrenia Research Fund and the National Alliance for Research on Schizophrenia and Depression, The Psychiatry Research Trust and the British Medical Association. E. Bramon was supported by a fellowship from The Wellcome Trust, a NARSAD young investigator award and a post-doctoral fellowship from the UK's Department of Health. M. Shaikh is sponsored by the Psychiatry Research Trust. Our special thanks go to all the people who volunteered to take part in this research.

PY - 2008/6

Y1 - 2008/6

N2 - Background: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable. Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression. Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk.

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Abnormal P300 in people with high risk of developing psychosis

Abstract

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ASJC Scopus subject areas

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