TY - JOUR
T1 - A secretome view of colonisation factors in Shiga toxin-encoding Escherichia coli (STEC):
T2 - from enterohaemorrhagic E. coli (EHEC) to related enteropathotypes
AU - Monteiro, Ricardo
AU - Ageorges, Valentin
AU - Rojas-Lopez, Maricarmen
AU - Schmidt, Herbert
AU - Weiss, Agnes
AU - Bertin, Yolande
AU - Forano, Evelyne
AU - Jubelin, Grégory
AU - Henderson, Ian
AU - Livrelli, Valérie
AU - Gobert, Alain P
AU - Rosini, Roberto
AU - Soriani, Marco
AU - Desvaux, Mickaël
N1 - © FEMS 2016. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Shiga toxin-encoding Escherichia coli (STEC) regroup strains that carry genes encoding Shiga toxin (Stx). Among intestinal pathogenic E. coli, enterohaemorrhagic E. coli (EHEC) constitute the major subgroup of virulent STEC. EHEC cause serious human disease such as haemorrhagic colitis and haemolytic-uremic syndrome. While EHEC have evolved from enteropathogenic E. coli, hybrids with enteroaggregative E. coli have recently emerged. Of note, some enteroinvasive E. coli also belong to the STEC group. While the LEE (locus of enterocyte effacement) is a key and prominent molecular determinant in the pathogenicity, neither all EHEC nor STEC contain the LEE, suggesting that they possess additional virulence and colonisation factors. Currently, nine protein secretion systems have been described in diderm-lipopolysaccharide bacteria (archetypal Gram-negative) and can be involved in the secretion of extracellular effectors, cell-surface proteins or assembly of cell-surface organelles, such as flagella or pili. In this review, we focus on the secretome of STEC and related enteropathotypes, which are relevant to the colonisation of biotic and abiotic surfaces. Considering the wealth of potential protein trafficking mechanisms, the different combinations of colonisation factors and modulation of their expression is further emphasised with regard to the ecophysiology of STEC.
AB - Shiga toxin-encoding Escherichia coli (STEC) regroup strains that carry genes encoding Shiga toxin (Stx). Among intestinal pathogenic E. coli, enterohaemorrhagic E. coli (EHEC) constitute the major subgroup of virulent STEC. EHEC cause serious human disease such as haemorrhagic colitis and haemolytic-uremic syndrome. While EHEC have evolved from enteropathogenic E. coli, hybrids with enteroaggregative E. coli have recently emerged. Of note, some enteroinvasive E. coli also belong to the STEC group. While the LEE (locus of enterocyte effacement) is a key and prominent molecular determinant in the pathogenicity, neither all EHEC nor STEC contain the LEE, suggesting that they possess additional virulence and colonisation factors. Currently, nine protein secretion systems have been described in diderm-lipopolysaccharide bacteria (archetypal Gram-negative) and can be involved in the secretion of extracellular effectors, cell-surface proteins or assembly of cell-surface organelles, such as flagella or pili. In this review, we focus on the secretome of STEC and related enteropathotypes, which are relevant to the colonisation of biotic and abiotic surfaces. Considering the wealth of potential protein trafficking mechanisms, the different combinations of colonisation factors and modulation of their expression is further emphasised with regard to the ecophysiology of STEC.
KW - Bacterial Outer Membrane Proteins/secretion
KW - Bacterial Secretion Systems
KW - Enterohemorrhagic Escherichia coli/growth & development
KW - Escherichia coli Infections/microbiology
KW - Escherichia coli Proteins/genetics
KW - Genes, Bacterial
KW - Humans
KW - Proteome/metabolism
KW - Shiga-Toxigenic Escherichia coli/growth & development
KW - Virulence
KW - Virulence Factors
U2 - 10.1093/femsle/fnw179
DO - 10.1093/femsle/fnw179
M3 - Review article
C2 - 27465489
SN - 0378-1097
VL - 363
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 16
M1 - fnw179
ER -