Abstract
Introduction
Hospital-acquired pneumonia (HAP) is the most common healthcare-associated infection (HCAI) contributing to death. Rising antimicrobial resistance has resulted in few effective antibiotics for HAP. Stimulation of human immunity and immunomodulation have been reported as a role of vitamin D.
Objectives
The objectives of this study were to investigate vitamin D status of HAP patients and to examine if vitamin D status was related to the severity of HAP.
Method
Patients with a diagnosis were recruited for a 3-month period from two acute hospitals. Vitamin D levels of participants were obtained.
Key findings
Sixty-one participants were recruited with a mean age 72 years, with 77% of the participants over 65 years of age. Severe HAP was diagnosed in 92% of the participants, 5% had moderate and 3% had mild HAP. Vitamin D deficiency (Conclusion
Vitamin D deficiency was highly prevalent in the HAP participants. Vitamin D deficiency was also present in some participants, despite prescribed prophylactic supplementation. Vitamin D stimulates immunity and hence vitamin D deficiency would have potentially increased the susceptibility of acquiring HAP.
Hospital-acquired pneumonia (HAP) is the most common healthcare-associated infection (HCAI) contributing to death. Rising antimicrobial resistance has resulted in few effective antibiotics for HAP. Stimulation of human immunity and immunomodulation have been reported as a role of vitamin D.
Objectives
The objectives of this study were to investigate vitamin D status of HAP patients and to examine if vitamin D status was related to the severity of HAP.
Method
Patients with a diagnosis were recruited for a 3-month period from two acute hospitals. Vitamin D levels of participants were obtained.
Key findings
Sixty-one participants were recruited with a mean age 72 years, with 77% of the participants over 65 years of age. Severe HAP was diagnosed in 92% of the participants, 5% had moderate and 3% had mild HAP. Vitamin D deficiency (Conclusion
Vitamin D deficiency was highly prevalent in the HAP participants. Vitamin D deficiency was also present in some participants, despite prescribed prophylactic supplementation. Vitamin D stimulates immunity and hence vitamin D deficiency would have potentially increased the susceptibility of acquiring HAP.
Original language | English |
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Article number | rqad018 |
Pages (from-to) | 1-4 |
Number of pages | 4 |
Journal | RPS Pharmacy and Pharmacology Reports |
Volume | 2 |
Issue number | 2 |
DOIs | |
Publication status | Published - 16 May 2023 |
Keywords
- hospital-acquired pneumonia
- vitamin d
- severity of infection