Abstract
Inspired by interlocked oligonucleotides, peptides and knotted proteins, synthetic systems where a macrocycle cages a bioactive species that is “switched on” by breaking the mechanical bond have been reported. However, to date, each example uses a bespoke chemical design. Here we present a platform approach to mechanically caged structures wherein a single macrocycle precursor is diversified at a late stage to include a range of trigger units that control ring opening in response to enzymatic, chemical, or photochemical stimuli. We also demonstrate that our approach is applicable to other classes of macrocycles suitable for rotaxane and catenane formation.
Original language | English |
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Article number | e202400344 |
Number of pages | 7 |
Journal | Angewandte Chemie (International Edition) |
Volume | 2024 |
Early online date | 26 Jan 2024 |
DOIs | |
Publication status | Published - 6 Mar 2024 |
Bibliographical note
SMG thanks the ERC (Agreement no. 724987) and Leverhulme Trust (RPG-2020-399) for funding and the Royal Society for a Wolfson Research Fellowship (RSWF\FT\180010). A. Saady thanks the Council for Higher Education-Israel for a personal fellowship.Keywords
- crown ethers
- macrocycles
- mechanical bonds
- prodrugs
- rotaxanes
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Research data supporting the publication "A Platform Approach to Cleavable Macrocycles for the Controlled Disassembly of Mechanically Caged Molecules"
Goldup, S. (Creator), University of Birmingham, 26 Jan 2024
DOI: 10.25500/edata.bham.00001053
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