A P300-based cognitive assessment battery

Aaron Kirschner, Damian Cruse, Srivas Chennu, Adrian M Owen, Adam Hampshire

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


BACKGROUND: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes.

METHODS: Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls.

RESULTS: Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems.

CONCLUSION: We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness.

Original languageEnglish
Pages (from-to)e00336
JournalBrain and Behavior
Issue number6
Publication statusPublished - Jun 2015


  • Cognition
  • Electroencephalography
  • Evoked Potentials
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Memory, Short-Term
  • Persistent Vegetative State
  • Point-of-Care Testing
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Synaptic Transmission
  • Task Performance and Analysis
  • Young Adult


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