Abstract
A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly-identified mcr-3, and a carbapenemase gene blaNDM-5mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by an TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.
Original language | English |
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Journal | Antimicrobial Agents and Chemotherapy |
Volume | 61 |
Issue number | 12 |
Early online date | 2 Oct 2017 |
DOIs | |
Publication status | Published - 1 Dec 2017 |