A habenula-insular circuit encodes the willingness to act

Nima Khalighinejad*, Neil Garrett, Luke Priestley, Patricia Lockwood, Matthew F. S. Rushworth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

The decision that it is worth doing something rather than nothing is a core yet understudied feature of voluntary behaviour. Here we study “willingness to act”, the probability of making a response given the context. Human volunteers encountered opportunities to make effortful actions in order to receive rewards, while watching a movie inside a 7 T MRI scanner. Reward and other context features determined willingness-to-act. Activity in the habenula tracked trial-by-trial variation in participants’ willingness-to-act. The anterior insula encoded individual environment features that determined this willingness. We identify a multi-layered network in which contextual information is encoded in the anterior insula, converges on the habenula, and is then transmitted to the supplementary motor area, where the decision is made to either act or refrain from acting via the nigrostriatal pathway.
Original languageEnglish
Article number6329
Number of pages12
JournalNature Communications
Volume12
Issue number1
Early online date3 Nov 2021
DOIs
Publication statusPublished - Dec 2021

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