A ferrocenyl-DHIPOH/Cu(OAc)2 complex for diastereo- and enantioselective catalysis of the 1,4-addition of glycine derivatives to alkylidene malonates

Yu-Hua Shi; Zheng Wang; Bin Hu; Ming Wang; John S Fossey; Wei-Ping Deng

doi:10.1021/ol202466v

A ferrocenyl-DHIPOH/Cu(OAc)2 complex for diastereo- and enantioselective catalysis of the 1,4-addition of glycine derivatives to alkylidene malonates

Yu-Hua Shi, Zheng Wang, Bin Hu, Ming Wang, John S Fossey, Wei-Ping Deng

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.

Original language	English
Pages (from-to)	6010-3
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	22
DOIs	https://doi.org/10.1021/ol202466v
Publication status	Published - 2011

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title = "A ferrocenyl-DHIPOH/Cu(OAc)2 complex for diastereo- and enantioselective catalysis of the 1,4-addition of glycine derivatives to alkylidene malonates",

abstract = "A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.",

author = "Yu-Hua Shi and Zheng Wang and Bin Hu and Ming Wang and Fossey, {John S} and Wei-Ping Deng",

year = "2011",

doi = "10.1021/ol202466v",

language = "English",

volume = "13",

pages = "6010--3",

journal = "Organic Letters",

publisher = "American Chemical Society",

number = "22",

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T1 - A ferrocenyl-DHIPOH/Cu(OAc)2 complex for diastereo- and enantioselective catalysis of the 1,4-addition of glycine derivatives to alkylidene malonates

AU - Shi, Yu-Hua

AU - Wang, Zheng

AU - Hu, Bin

AU - Wang, Ming

AU - Fossey, John S

AU - Deng, Wei-Ping

PY - 2011

Y1 - 2011

N2 - A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.

AB - A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.

U2 - 10.1021/ol202466v

DO - 10.1021/ol202466v

M3 - Article

C2 - 22007626

VL - 13

SP - 6010

EP - 6013

JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

A ferrocenyl-DHIPOH/Cu(OAc)2 complex for diastereo- and enantioselective catalysis of the 1,4-addition of glycine derivatives to alkylidene malonates

Abstract

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