A common variant associated with prostate cancer in European and African populations

Laufey T Amundadottir; Patrick Sulem; Julius Gudmundsson; Agnar Helgason; Adam Baker; Bjarni A Agnarsson; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Jean-Baptiste Cazier; Jesus Sainz; Margret Jakobsdottir; Jelena Kostic; Droplaug N Magnusdottir; Shyamali Ghosh; Kari Agnarsson; Birgitta Birgisdottir; Louise Le Roux; Adalheidur Olafsdottir; Thorarinn Blondal; Margret Andresdottir; Olafia Svandis Gretarsdottir; Jon T Bergthorsson; Daniel Gudbjartsson; Arnaldur Gylfason; Gudmar Thorleifsson; Andrei Manolescu; Kristleifur Kristjansson; Gudmundur Geirsson; Helgi Isaksson; Julie Douglas; Jan-Erik Johansson; Katarina Bälter; Fredrik Wiklund; James E Montie; Xiaoying Yu; Brian K Suarez; Carole Ober; Kathleen A Cooney; Henrik Gronberg; William J Catalona; Gudmundur V Einarsson; Rosa B Barkardottir; Jeffrey R Gulcher; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson

doi:10.1038/ng1808

A common variant associated with prostate cancer in European and African populations

Laufey T Amundadottir, Patrick Sulem, Julius Gudmundsson, Agnar Helgason, Adam Baker, Bjarni A Agnarsson, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Jean-Baptiste Cazier, Jesus Sainz, Margret Jakobsdottir, Jelena Kostic, Droplaug N Magnusdottir, Shyamali Ghosh, Kari Agnarsson, Birgitta Birgisdottir, Louise Le Roux, Adalheidur Olafsdottir, Thorarinn Blondal, Margret AndresdottirOlafia Svandis Gretarsdottir, Jon T Bergthorsson, Daniel Gudbjartsson, Arnaldur Gylfason, Gudmar Thorleifsson, Andrei Manolescu, Kristleifur Kristjansson, Gudmundur Geirsson, Helgi Isaksson, Julie Douglas, Jan-Erik Johansson, Katarina Bälter, Fredrik Wiklund, James E Montie, Xiaoying Yu, Brian K Suarez, Carole Ober, Kathleen A Cooney, Henrik Gronberg, William J Catalona, Gudmundur V Einarsson, Rosa B Barkardottir, Jeffrey R Gulcher, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

590 Citations (Scopus)

Abstract

With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

Original language	English
Pages (from-to)	652-8
Number of pages	7
Journal	Nature Genetics
Volume	38
Issue number	6
DOIs	https://doi.org/10.1038/ng1808
Publication status	Published - Jun 2006

Keywords

African Continental Ancestry Group
Alleles
European Continental Ancestry Group
Humans
Male
Microsatellite Repeats
Polymorphism, Single Nucleotide
Prostatic Neoplasms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng1808

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Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., Sigurdsson, A., Benediktsdottir, K. R., Cazier, J.-B., Sainz, J., Jakobsdottir, M., Kostic, J., Magnusdottir, D. N., Ghosh, S., Agnarsson, K., Birgisdottir, B., Le Roux, L., Olafsdottir, A., Blondal, T., ... Stefansson, K. (2006). A common variant associated with prostate cancer in European and African populations. Nature Genetics, 38(6), 652-8. https://doi.org/10.1038/ng1808

@article{af07217086fa491a9c6b6b6d8cf9d556,

title = "A common variant associated with prostate cancer in European and African populations",

abstract = "With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.",

keywords = "African Continental Ancestry Group, Alleles, European Continental Ancestry Group, Humans, Male, Microsatellite Repeats, Polymorphism, Single Nucleotide, Prostatic Neoplasms",

author = "Amundadottir, {Laufey T} and Patrick Sulem and Julius Gudmundsson and Agnar Helgason and Adam Baker and Agnarsson, {Bjarni A} and Asgeir Sigurdsson and Benediktsdottir, {Kristrun R} and Jean-Baptiste Cazier and Jesus Sainz and Margret Jakobsdottir and Jelena Kostic and Magnusdottir, {Droplaug N} and Shyamali Ghosh and Kari Agnarsson and Birgitta Birgisdottir and {Le Roux}, Louise and Adalheidur Olafsdottir and Thorarinn Blondal and Margret Andresdottir and Gretarsdottir, {Olafia Svandis} and Bergthorsson, {Jon T} and Daniel Gudbjartsson and Arnaldur Gylfason and Gudmar Thorleifsson and Andrei Manolescu and Kristleifur Kristjansson and Gudmundur Geirsson and Helgi Isaksson and Julie Douglas and Jan-Erik Johansson and Katarina B{\"a}lter and Fredrik Wiklund and Montie, {James E} and Xiaoying Yu and Suarez, {Brian K} and Carole Ober and Cooney, {Kathleen A} and Henrik Gronberg and Catalona, {William J} and Einarsson, {Gudmundur V} and Barkardottir, {Rosa B} and Gulcher, {Jeffrey R} and Augustine Kong and Unnur Thorsteinsdottir and Kari Stefansson",

year = "2006",

month = jun,

doi = "10.1038/ng1808",

language = "English",

volume = "38",

pages = "652--8",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "6",

}

Amundadottir, LT, Sulem, P, Gudmundsson, J, Helgason, A, Baker, A, Agnarsson, BA, Sigurdsson, A, Benediktsdottir, KR, Cazier, J-B, Sainz, J, Jakobsdottir, M, Kostic, J, Magnusdottir, DN, Ghosh, S, Agnarsson, K, Birgisdottir, B, Le Roux, L, Olafsdottir, A, Blondal, T, Andresdottir, M, Gretarsdottir, OS, Bergthorsson, JT, Gudbjartsson, D, Gylfason, A, Thorleifsson, G, Manolescu, A, Kristjansson, K, Geirsson, G, Isaksson, H, Douglas, J, Johansson, J-E, Bälter, K, Wiklund, F, Montie, JE, Yu, X, Suarez, BK, Ober, C, Cooney, KA, Gronberg, H, Catalona, WJ, Einarsson, GV, Barkardottir, RB, Gulcher, JR, Kong, A, Thorsteinsdottir, U & Stefansson, K 2006, 'A common variant associated with prostate cancer in European and African populations', Nature Genetics, vol. 38, no. 6, pp. 652-8. https://doi.org/10.1038/ng1808

TY - JOUR

T1 - A common variant associated with prostate cancer in European and African populations

AU - Amundadottir, Laufey T

AU - Sulem, Patrick

AU - Gudmundsson, Julius

AU - Helgason, Agnar

AU - Baker, Adam

AU - Agnarsson, Bjarni A

AU - Sigurdsson, Asgeir

AU - Benediktsdottir, Kristrun R

AU - Cazier, Jean-Baptiste

AU - Sainz, Jesus

AU - Jakobsdottir, Margret

AU - Kostic, Jelena

AU - Magnusdottir, Droplaug N

AU - Ghosh, Shyamali

AU - Agnarsson, Kari

AU - Birgisdottir, Birgitta

AU - Le Roux, Louise

AU - Olafsdottir, Adalheidur

AU - Blondal, Thorarinn

AU - Andresdottir, Margret

AU - Gretarsdottir, Olafia Svandis

AU - Bergthorsson, Jon T

AU - Gudbjartsson, Daniel

AU - Gylfason, Arnaldur

AU - Thorleifsson, Gudmar

AU - Manolescu, Andrei

AU - Kristjansson, Kristleifur

AU - Geirsson, Gudmundur

AU - Isaksson, Helgi

AU - Douglas, Julie

AU - Johansson, Jan-Erik

AU - Bälter, Katarina

AU - Wiklund, Fredrik

AU - Montie, James E

AU - Yu, Xiaoying

AU - Suarez, Brian K

AU - Ober, Carole

AU - Cooney, Kathleen A

AU - Gronberg, Henrik

AU - Catalona, William J

AU - Einarsson, Gudmundur V

AU - Barkardottir, Rosa B

AU - Gulcher, Jeffrey R

AU - Kong, Augustine

AU - Thorsteinsdottir, Unnur

AU - Stefansson, Kari

PY - 2006/6

Y1 - 2006/6

N2 - With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

AB - With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

KW - African Continental Ancestry Group

KW - Alleles

KW - European Continental Ancestry Group

KW - Humans

KW - Male

KW - Microsatellite Repeats

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms

U2 - 10.1038/ng1808

DO - 10.1038/ng1808

M3 - Article

C2 - 16682969

SN - 1061-4036

VL - 38

SP - 652

EP - 658

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

A common variant associated with prostate cancer in European and African populations

Abstract

Keywords

UN SDGs

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