A 13-year patient journey of infant giant clival chordoma: case report and literature review

J Apps, R Gagen, E Neumann, G Solanki, M English*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Chordomas are rare malignant bone tumours that develop from the ectopic remnants of the embryonic notochord. In contrast to adults, the majority in children under 16 present intra-cranially (63%). In 2006, we reported the youngest case of a large clival chordoma, a 15-week old baby, the second case to present without skull base involvement and the fourth case of chordoma in a patient with tuberous sclerosis (TS) Kombogiorgas (Childs Nerv Syst 22(10):1369-1374, 2006). In this report, we provide an update on this patient's journey through a range of therapeutic options and summarize an update of the literature, since 2006, for this patient group.

Original languageEnglish
JournalChild's Nervous System
Early online date22 Nov 2022
DOIs
Publication statusE-pub ahead of print - 22 Nov 2022

Bibliographical note

© 2022. The Author(s).

Keywords

  • Infant clival chordoma
  • Imatinib
  • mTOR

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