A 13-year patient journey of infant giant clival chordoma: case report and literature review

J Apps; R Gagen; E Neumann; G Solanki; M English

doi:10.1007/s00381-022-05749-4

A 13-year patient journey of infant giant clival chordoma: case report and literature review

J Apps, R Gagen, E Neumann, G Solanki, M English^*

^*Corresponding author for this work

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Abstract

Chordomas are rare malignant bone tumours that develop from the ectopic remnants of the embryonic notochord. In contrast to adults, the majority in children under 16 present intra-cranially (63%). In 2006, we reported the youngest case of a large clival chordoma, a 15-week old baby, the second case to present without skull base involvement and the fourth case of chordoma in a patient with tuberous sclerosis (TS) Kombogiorgas (Childs Nerv Syst 22(10):1369-1374, 2006). In this report, we provide an update on this patient's journey through a range of therapeutic options and summarize an update of the literature, since 2006, for this patient group.

Original language	English
Journal	Child's Nervous System
Early online date	22 Nov 2022
DOIs	https://doi.org/10.1007/s00381-022-05749-4
Publication status	E-pub ahead of print - 22 Nov 2022

Bibliographical note

Keywords

Infant clival chordoma
Imatinib
mTOR

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AU - Solanki, G

AU - English, M

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AB - Chordomas are rare malignant bone tumours that develop from the ectopic remnants of the embryonic notochord. In contrast to adults, the majority in children under 16 present intra-cranially (63%). In 2006, we reported the youngest case of a large clival chordoma, a 15-week old baby, the second case to present without skull base involvement and the fourth case of chordoma in a patient with tuberous sclerosis (TS) Kombogiorgas (Childs Nerv Syst 22(10):1369-1374, 2006). In this report, we provide an update on this patient's journey through a range of therapeutic options and summarize an update of the literature, since 2006, for this patient group.

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ER -

A 13-year patient journey of infant giant clival chordoma: case report and literature review

Abstract

Bibliographical note

Keywords

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