The Development of Cellular Therapy for the Correction of CMV-Specific Immunodeficiency After Stem Cell Transplantation

Research output

Research output per year 2005 2005 2006 2008 2009 2010 2013 2013

• 11 Article

Research output per year

Research output per year

Search results

• Article

  Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin alpha4beta7

  Chakupurakal, G., Onion, D., Cobbold, M., Mautner, V. & Moss, P., 27 Oct 2009, In: Aids.

  Research output: Contribution to journal › Article › peer-review

  File

  • integrin alpha4beta7 100%
  • Adenoviridae 48%
  • Memory 36%
  • T-Lymphocytes 30%
  • Phenotype 29%
  9 Citations (Scopus)

  363 Downloads (Pure)

• Adoptive immunotherapy with allodepleted donor T cells improves immune reconstitution after haploidentical stem cell transplantation

  Amrolia, PJ., Nyccuiku-Casadeu, G., Huls, H., Adams, S., Durett, A., Gee, A., Yvon, E., Weiss, H., Cobbold, M., Gaspar, HB., Rooney, C., Kuehnle, I., Ghetie, V., Schindler, J., Krance, R., Heslop, HE., Veys, P., Vitetta, E. & Brenner, MK., 15 Sept 2006, In: Blood. 108, 6, p. 1797-1808 12 p.

  Research output: Contribution to journal › Article

  • Immune Reconstitution 100%
  • Adoptive Immunotherapy 99%
  • Stem Cell Transplantation 79%
  • Tissue Donors 59%
  • Dose 58%
  194 Citations (Scopus)

• Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers

  Cobbold, M., Khan, N., Pourgheysari Najafabadi, B., Tauro, S., McDonald, D., Osman, H., Assenmacher, M., Billingham, L., Steward, C., Crawley, C., Olavarria, E., Goldman, J., Chakraverty, R., Mahendra, P., Craddock, C. & Moss, P., 1 Aug 2005, In: The Journal of Experimental Medicine. 202, 3, p. 379-386 8 p.

  Research output: Contribution to journal › Article

  • Adoptive Transfer 100%
  • Cytomegalovirus 86%
  • Patient Selection 75%
  • Stem Cells 63%
  • Peptides 55%
  404 Citations (Scopus)

• Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults

  MacLennan, C., Gilchrist, JJ., Gordon, MA., Cunningham, A., Cobbold, M., Goodall, D., Kingsley, RA., van Oosterhout, JJG., Msefula, CL., Mandala, WL., Leyton, D., Marshall, J., Gondwe, E., Bobat, S., Lopez-Macias, C., Doffinger, R., Henderson, I., Zijlstra, EE., Dougan, G., Drayson, M., & 2 othersMacLennan, I. & Molyneux, ME., 1 Apr 2010, In: Science. 328, 5977, p. 508-512 5 p.

  Research output: Contribution to journal › Article

  • Salmonella 100%
  • Humoral Immunity 98%
  • HIV 65%
  • Lipopolysaccharides 40%
  • Antibodies 36%
  119 Citations (Scopus)

• HLA-peptide multimer selection of adenovirus-specific T cells for adoptive T-cell therapy

  Chakupurakal, G., Onion, D., Bonney, S., Cobbold, M., Mautner, V. & Moss, P., Oct 2013, In: Journal of Immunotherapy. 36, 8, p. 423-31 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenoviridae 100%
  • Cell- and Tissue-Based Therapy 96%
  • Adenoviridae Infections 83%
  • Adoptive Transfer 70%
  • Peptides 65%
  10 Citations (Scopus)

• In treatment-naive and antiretroviral-treated subjects with HIV, reduced plasma adiponectin is associated with a reduced fractional clearance rate of VLDL, IDL and LDL apoliopoprotein B-100

  Das, S., Shahmanesh, M., Stolinski, M., Shojaee-Moradie, F., Jefferson, W., Jackson, N., Cobbold, M., Nightingale, P. & Empleby, AM., 1 Mar 2006, In: Diabetologia. 49, p. 538-542 5 p.

  Research output: Contribution to journal › Article

  • Adiponectin 100%
  • oxidized low density lipoprotein 93%
  • HIV 64%
  • Apolipoproteins B 51%
  • Tumor Necrosis Factor Receptors 26%
  30 Citations (Scopus)

• MHC class I–associated phosphopeptides are the targets of memory-like immunity in Leukemia

  Cobbold, M., De La Pena, H., Norris, A., Polefrone, J. M., Qian, J., English, A. M., Cummings, K. L., Penny, S., Turner, J. E., Cottine, J., Abelin, J. G., Malaker, S. A., Zarling, A. L., Huang, H-W., Goodyear, O., Freeman, S. D., Shabanowitz, J., Pratt, G., Craddock, C., Williams, M. E., & 2 othersHunt, D. F. & Engelhard, V. H., 18 Sept 2013, In: Science Translational Medicine. 5, 203, p. 203ra125

  Research output: Contribution to journal › Article › peer-review

  • Phosphopeptides 100%
  • Major Histocompatibility Complex 76%
  • Leukemia 61%
  • Immunity 61%
  • Memory 54%
  115 Citations (Scopus)

• Persistent viral infection in humans can drive high frequency low-affinity T-cell expansions

  Khan, N., Cobbold, M., Cummerson, J. & Moss, P., 1 Dec 2010, In: Immunology. 131, 4, p. 537-548 12 p.

  Research output: Contribution to journal › Article

  • Cytomegalovirus 100%
  • Virus Diseases 73%
  • Peptides 64%
  • T-Lymphocytes 62%
  • Ligands 35%
  13 Citations (Scopus)

• Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self.

  Mohammed, F., Cobbold, M., Zarling, AL., Salim, M., Barrett-Wilt, GA., Shabanowitz, J., Hunt, DF., Engelhard, VH. & Willcox, B., 1 Nov 2008, In: Nature Immunology. 9, 11, p. 1236-43 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphopeptides 100%
  • Histocompatibility Antigens Class I 88%
  • Phosphorylation 51%
  • HLA-A2 Antigen 51%
  • Major Histocompatibility Complex 38%
  87 Citations (Scopus)

• Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition

  Nicholls, S., Piper, K., Mohammed, F., Dafforn, T., Tenzer, S., Salim, M., Mahendra, P., Craddock, C., van Endert, P., Schild, H., Cobbold, M., Engelhard, VH., Moss, P. & Willcox, B., 10 Mar 2009, In: National Academy of Sciences. Proceedings. 106, 10, p. 3889-94 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Minor Histocompatibility Antigens 100%
  • HLA-A2 Antigen 67%
  • T-Lymphocytes 40%
  • Peptides 31%
  • Amino Acids 23%
  28 Citations (Scopus)

• Selection of CMV-specific CD8(+) and CD4(+) T cells by mini-EBV-transformed B cell lines

  Wiesner, M., Zentz, C., Hammer, MH., Cobbold, M., Kern, F., Kolb, HJ., Hammerschmidt, W., Zeidler, R. & Moosmann, A., 1 Jul 2005, In: European Journal of Immunology. 35, 7, p. 2110-2121 12 p.

  Research output: Contribution to journal › Article

  • Transformed Cell Line 100%
  • Cytomegalovirus 78%
  • Human Herpesvirus 4 77%
  • B-Lymphocytes 60%
  • T-Lymphocytes 48%
  23 Citations (Scopus)