Sustained treatment of Idiopathic Intracranial Hypertension (IIH) through weight loss induced by bariatric surgery

Research output

Research output per year 2020 2021 2022 2023 2024

• 19 Article
• 3 Review article

Research output per year

Research output per year

Search results

• 2024

  Effect of glucagon like peptide-1 receptor agonist exenatide, used as an intracranial pressure lowering agent, on cognition in Idiopathic Intracranial Hypertension

  Grech, O., Mitchell, J., Lyons, H., Yiangou, A., Thaller, M., Tsermoulas, G., Brock, K., Mollan, S. & Sinclair, A., 11 Jan 2024, (E-pub ahead of print) In: Eye. 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Exenatide 99%
  • Glucagon-Like Peptide-1 Receptor 94%
  • Hypertension 91%
  • Intracranial Pressure 80%
• 2023

  Asymptomatic idiopathic intracranial hypertension: Prevalence and prognosis

  Thaller, M., Homer, V., Mollan, S. & Sinclair, A., 27 May 2023, (E-pub ahead of print) In: Clinical and Experimental Ophthalmology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Headache 41%
  • Papilledema 30%
  • Visual Fields 12%
  • Optical Coherence Tomography 12%
  68 Downloads (Pure)

• Depression and anxiety in women with idiopathic intracranial hypertension compared to migraine: a matched controlled cohort study

  Mollan, S., Subramanian, A., Perrins, M., Nirantharakumar, K., Adderley, N. & Sinclair, A., 15 Feb 2023, In: Headache. 63, p. 290-298 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Migraine Disorders 73%
  • Anxiety 52%
  • Cohort Studies 50%
  • Depression 48%
  116 Downloads (Pure)

• Determining the role of novel metabolic pathways in driving intracranial pressure reduction after weight loss

  Alimajstorovic, Z., Mitchell, J., Yiangou, A., Hancox, T., Southam, A., Grech, O., Ottridge, R., Winder, C., Tahrani, A., Tan, T. M., Mollan, S., Dunn, W. & Sinclair, A., 18 Oct 2023, (E-pub ahead of print) In: Brain Communications. 5, 5, 16 p., fcad272.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Intracranial Pressure 100%
  • Metabolic Networks and Pathways 91%
  • Weight Loss 74%
  • Glucagon-Like Peptide 1 64%
  • Pseudotumor Cerebri 62%
  74 Downloads (Pure)

• Longitudinal prospective cohort study evaluating prognosis in idiopathic intracranial hypertension patients with and without comorbid polycystic ovarian syndrome

  Thaller, M., Homer, V., Sassani, M., Mollan, S. P. & Sinclair, A. J., 24 May 2023, (E-pub ahead of print) In: Eye (London, England).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Hypertension 91%
  • Polycystic Ovary Syndrome 81%
  • Cohort 80%
  • Syndrome 64%
  23 Downloads (Pure)

• The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial

  Mitchell, J. L., Lyons, H. S., Walker, J. K., Yiangou, A., Grech, O., Alimajstorovic, Z., Greig, N. H., Li, Y., Tsermoulas, G., Brock, K., Mollan, S. P. & Sinclair, A. J., 1 May 2023, In: Brain. 146, 5, p. 1821-1830 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Exenatide 99%
  • Intracranial Pressure 80%
  • Randomized Controlled Trials 49%
  • Glucagon-Like Peptide-1 Receptor 28%
  43 Downloads (Pure)

• The Impact of Valsalva Manoeuvres and Exercise on Intracranial Pressure and Cerebrovascular Dynamics in Idiopathic Intracranial Hypertension

  Yiangou, A., Weaver, S. R. C., Thaller, M., Mitchell, J. L., Lyons, H. S., Tsermoulas, G., Mollan, S. P., Lucas, S. J. E. & Sinclair, A. J., 22 Nov 2023, (E-pub ahead of print) In: Neuro-Ophthalmology. 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Valsalva Maneuver 96%
  • Intracranial Pressure 80%
  • Hemodynamics 19%
  • Intracranial Hypertension 15%
  6 Downloads (Pure)
• 2022

  Alterations in metabolic flux in migraine and the translational relevance

  Grech, O., Sassani, M., Terwindt, G., Lavery, G., Mollan, S. & Sinclair, A., 30 Sept 2022, (E-pub ahead of print) In: The Journal of Headache and Pain. 23, 1, 12 p., 127.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Migraine Disorders 100%
  • Nociception 33%
  • Calcitonin Gene-Related Peptide 33%
  • Cortical Spreading Depression 21%
  • Biomarkers 18%
  29 Downloads (Pure)

• Association of amount of weight lost after bariatric surgery with intracranial pressure in women with idiopathic intracranial hypertension

  Mollan, S. P., Mitchell, J. L., Yiangou, A., Ottridge, R. S., Alimajstorovic, Z., Cartwright, D. M., Hickman, S. J., Markey, K. A., Singhal, R., Tahrani, A. A., Frew, E., Brock, K. & Sinclair, A. J., 13 Sept 2022, In: Neurology. 99, 11, p. e1090-e1099 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Bariatric Surgery 81%
  • Intracranial Pressure 80%
  • Weight Loss 60%
  • Weights and Measures 46%
  117 Downloads (Pure)

• Dysregulation of amino acid, lipid and acylpyruvate metabolism in idiopathic intracranial hypertension: a non-targeted case control and longitudinal metabolomic study

  Alimajstorovic, Z., Mollan, S., Grech, O., Mitchell, J., Yiangou, A., Thaller, M., Lyons, H., Sassani, M., Seneviratne, S., Hancox, T., Jankevics, A., Najdekr, L., Dunn, W. & Sinclair, A., 19 Dec 2022, (E-pub ahead of print) In: Journal of Proteome Research. 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Intracranial 100%
  • Pseudotumor Cerebri 85%
  • Metabolomics 68%
  • Lipid Metabolism 60%
  • Longitudinal Studies 52%
  55 Downloads (Pure)

• Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension

  Mitchell, J., Buckham, R., Lyons, H., Walker, J., Yiangou, A., Sassani, M., Thaller, M., Grech, O., Alimajstorovic, Z., Julher, M., Tsermoulas, G., Brock, K., Mollan, S. & Sinclair, A., 1 Nov 2022, In: Fluids and barriers of the CNS. 19, 1, 11 p., 85.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Supine Position 81%
  • Intracranial Pressure 80%
  • Sitting Position 15%
  • Posture 14%
  48 Downloads (Pure)

• Headache, opiate use, and prescribing trends in women with idiopathic intracranial hypertension: a population-based matched cohort study

  Adderley, N., Subramanian, A., Perrins, M., Nirantharakumar, K., Mollan, S. & Sinclair, A., 19 Aug 2022, (E-pub ahead of print) In: Neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Opiate Alkaloids 79%
  • Headache 62%
  • Cohort Studies 50%
  • Migraine Disorders 41%
  71 Downloads (Pure)

• Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension

  Westgate, C. S. J., Markey, K., Mitchell, J. L., Yiangou, A., Singhal, R., Stewart, P., Tomlinson, J. W., Lavery, G. G., Mollan, S. P. & Sinclair, A. J., 1 Aug 2022, In: European Journal of Endocrinology. 187, 2, p. 323–333 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Glucocorticoids 30%
  • Bariatric Surgery 22%
  • Intracranial Pressure 21%
  • Weight Loss 16%
  33 Downloads (Pure)

• Nuclear magnetic resonance spectroscopy metabolomics in Idiopathic Intracranial Hypertension to identify markers of disease and headache

  Grech, O., Seneviratne, S., Alimajstorovic, Z., Yiangou, A., Mitchell, J., Smith, T., Mollan, S., Lavery, G., Ludwig, C. & Sinclair, A., 8 Sept 2022, (E-pub ahead of print) In: Neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Metabolomics 80%
  • Headache 62%
  • Magnetic Resonance Spectroscopy 61%
  • Urine 22%
  28 Downloads (Pure)

• The idiopathic intracranial hypertension prospective cohort study: evaluation of prognostic factors and outcomes

  Thaller, M., Homer, V., Hyder, Y., Yiangou, A., Liczkowski, A., Fong, A., Virdee, J., Piccus, R., Roque, M., Mollan, S. & Sinclair, A., 15 Oct 2022, (E-pub ahead of print) In: Journal of Neurology. 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Headache 62%
  • Cohort Studies 50%
  • Prospective Studies 46%
  • Optical Coherence Tomography 43%
  96 Downloads (Pure)
• 2021

  11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension

  Hardy, R., Botfield, H., Markey, K., Mitchell, J., Alimajstorovic, Z., Westgate, C., Sagmeister, M., Fairclough, R., Ottridge, R., Yiangou, A., Storbeck, K-H., Taylor, A., Gilligan, L., Arlt, W., Stewart, P., Tomlinson, J., Mollan, S., Lavery, G. & Sinclair, A., 1 Jan 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. 174-187 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid 100%
  • Intracranial 65%
  • Pseudotumor Cerebri 55%
  • 11-beta-Hydroxysteroid Dehydrogenases 39%
  • Marker 35%
  4 Citations (Scopus)

  192 Downloads (Pure)

• Cognitive performance in idiopathic intracranial hypertension and relevance of intracranial pressure

  Grech, O., Clouter, A., Mitchell, J., Alimajstorovic, Z., Ottridge, R., Yiangou, A., Roque, M., Tahrani, A., Nicholls, M., Taylor, A., Shaheen, F., Arlt, W., Lavery, G., Shapiro, K., Mollan, S. & Sinclair, A., 2 Sept 2021, In: Brain Communications. 3, 3, 14 p., fcab202.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Intracranial Pressure 80%
  • Cognition 33%
  • Obstructive Sleep Apnea 32%
  • Hydrocortisone 27%
  260 Downloads (Pure)

• Cost-effectiveness of bariatric surgery versus community weight management to treat obesity-related idiopathic intracranial hypertension: evidence from a single payer health care system

  Elliot, L., Frew, E., Mollan, S., Mitchell, J., Yiangou, A., Alimajstorovic, Z., Ottridge, R., Wakerley, B., Thaller, M., Grech, O., Singhal, R., Tahrani, A., Harrison, M., Sinclair, A. & Aguiar, M., 1 Jul 2021, In: Surgery for Obesity and Related Diseases. 17, 7, p. P1310-1316

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Intracranial Hypertension 87%
  • Bariatric Surgery 81%
  • Cost-Benefit Analysis 63%
  • Obesity 51%
  143 Downloads (Pure)

• Effectiveness of Bariatric Surgery vs Community Weight Management Intervention for the Treatment of Idiopathic Intracranial Hypertension: A Randomized Clinical Trial

  Mollan, S., Mitchell, J., Ottridge, R., Aguiar, M., Alimajstorovic, Z., Cartwright, D., Grech, O., Lavery, G., Westgate, C., Vijay, V., Scotton, W., Wakerley, B., Matthews, T., Ansons, A., Hickman, S., Benzimra, J., Rick, C., Singhal, R., Tahrani, A., Brock, K., & 2 othersFrew, E. & Sinclair, A., 1 Jun 2021, In: JAMA Neurology. 78, 6, p. 678-686

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Bariatric Surgery 81%
  • Cerebrospinal Fluid 63%
  • Randomized Controlled Trials 49%
  • Weights and Measures 46%
  4 Citations (Scopus)

  153 Downloads (Pure)

• Headache attributed to idiopathic intracranial hypertension and persistent post-idiopathic intracranial hypertension headache: a narrative review

  Mollan, S., Grech, O. & Sinclair, A., Jun 2021, In: Headache. 61, 6, p. 808-816 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Headache 62%
  • Intracranial Pressure 26%
  • Off-Label Use 8%
  • Papilledema 7%
  199 Downloads (Pure)

• Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension

  Westgate, C., Botfield, H., Alimajstorovic, Z., Yiangou, A., Walsh, M., Smith, G., Singhal, R., Mitchell, J., Grech, O., Markey, K., Hebenstreit, D., Tennant, D., Tomlinson, J., Mollan, S., Ludwig, C., Akerman, I., Lavery, G. & Sinclair, A., 24 May 2021, In: JCI Insight. 6, 10, e145346.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudotumor Cerebri 100%
  • Adipocytes 69%
  • Metabolic Diseases 17%
  • Leptin 16%
  • Adipose Tissue 13%
  1 Citation (Scopus)

  134 Downloads (Pure)
• 2020

  11β-hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial

  Markey, K., Mitchell, J., Botfield, H., Ottridge, R., Matthews, T., Krishnan, A., Woolley, R., Westgate, C., Yiangou, A., Alimajstorovic, Z., Shah, P., Rick, C., Ives, N., Taylor, A., Gilligan, L., Jenkinson, C., Arlt, W., Scotton, W., Fairclough, R. J., Singhal, R., & 5 othersStewart, P. M., Tomlinson, J. W., Lavery, G., Mollan, S. & Sinclair, A., 10 Jan 2020, In: Brain Communications. 2, 1, 12 p., fcz050.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid 100%
  • 11-beta-Hydroxysteroid Dehydrogenases 59%
  • Pseudotumor Cerebri 55%
  • Psychological Inhibition 33%
  • Spinal Puncture 30%
  203 Downloads (Pure)