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Pseudohypoxia-led identification of metabolic vulnerabilities in hypoxic tumours to improve patient outcomes
Tennant, Daniel
(Principal Investigator)
Ludwig, Christian
(Co-Investigator)
Metabolism and Systems Research
Overview
Fingerprint
Research output
(3)
Research output
Research output per year
2021
2021
2022
2023
2023
3
Article
Research output per year
Research output per year
3 results
Title
(ascending)
Publication Year, Title
Title
(descending)
Type
Search results
Mathematical reconstruction of the metabolic network in an in-vitro multiple myeloma model
Vera-Siguenza, E.
,
Escribano Gonzalez, C.
,
Serrano-Gonzalo, I.
,
Eskla, K-L.
,
Spill, F.
&
Tennant, D.
,
15 Sept 2023
,
In:
PLoS Computational Biology.
19
,
9
,
26 p.
, e1011374.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Metabolic Network
100%
Metabolic Networks and Pathways
90%
myeloma
84%
Multiple Models
84%
Multiple Myeloma
65%
33
Downloads (Pure)
Proline metabolism and redox; maintaining a balance in health and disease
Vettore, L. A.
,
Westbrook, R. L.
&
Tennant, D. A.
,
22 Jul 2021
, (E-pub ahead of print)
In:
Amino Acids.
53
,
12
,
p. 1779-1788
10 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Proline
100%
Oxidation-Reduction
90%
Pharmacological Metabolism
72%
Health
45%
Protein Structure
30%
135
Downloads (Pure)
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
Westbrook, R.
,
Bridges, E.
,
Roberts, J.
,
Escribano Gonzalez, C.
,
Eales, K.
,
Vettore, L.
,
Walker, P.
,
Vera-Siguenza, E.
,
Rana, H.
,
Cuozzo, F.
,
Eskla, K-L.
,
Vellama, H.
,
Shaaban, A.
,
Nixon, C.
,
Luuk, H.
,
Lavery, G.
,
Hodson, D.
,
Harris, A. L.
&
Tennant, D.
,
1 Feb 2022
,
In:
Cell Reports.
38
,
5
,
15 p.
, 110320.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Pyrroline Carboxylate Reductases
100%
delta-1-pyrroline-5-carboxylate
94%
Pyrroline
75%
Tricarboxylic Acid
68%
Citric Acid Cycle
65%
92
Downloads (Pure)