Pseudohypoxia-led identification of metabolic vulnerabilities in hypoxic tumours to improve patient outcomes

Tennant, Daniel (Principal Investigator)
Ludwig, Christian (Co-Investigator)

Metabolism and Systems Research

3 Article

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2023
Mathematical reconstruction of the metabolic network in an in-vitro multiple myeloma model
Vera-Siguenza, E., Escribano Gonzalez, C., Serrano-Gonzalo, I., Eskla, K-L., Spill, F. & Tennant, D., 15 Sept 2023, In: PLoS Computational Biology. 19, 9, 26 p., e1011374.
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Open Access
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2022
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
Westbrook, R., Bridges, E., Roberts, J., Escribano Gonzalez, C., Eales, K., Vettore, L., Walker, P., Vera-Siguenza, E., Rana, H., Cuozzo, F., Eskla, K-L., Vellama, H., Shaaban, A., Nixon, C., Luuk, H., Lavery, G., Hodson, D., Harris, A. L. & Tennant, D., 1 Feb 2022, In: Cell Reports. 38, 5, 15 p., 110320.
Research output: Contribution to journal › Article › peer-review

Open Access
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2021
Proline metabolism and redox; maintaining a balance in health and disease
Vettore, L. A., Westbrook, R. L. & Tennant, D. A., 22 Jul 2021, (E-pub ahead of print) In: Amino Acids. 53, 12, p. 1779-1788 10 p.
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