New Insights into the cellular response to complex DNA damage induced by proton beam therapy

Parsons, Jason (Principal Investigator)

Cancer and Genomic Sciences

Short title	New Insights into the cellular response to complex DNA damage induced by proton beam therapy
Status	Active
Effective start/end date	1/04/23 → 30/06/25

Funding

Medical Research Council

3 Review article
2 Article

Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation
Fabbrizi, M. R., Doggett, T. J., Hughes, J. R., Melia, E., Dufficy, E. R., Hill, R. M., Goula, A., Phoenix, B. & Parsons, J. L., 12 Jun 2024, In: Cell Death Discovery. 10, 1, 10 p., 282.
Research output: Contribution to journal › Article › peer-review

Open Access
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77 Downloads (Pure)
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence
Fabbrizi, M. R., Nickson, C. M., Hughes, J. R., Robinson, E. A., Vaidya, K., Rubbi, C. P., Kacperek, A., Bryant, H. E., Helleday, T. & Parsons, J. L., 17 Feb 2024, In: Cell Death and Disease. 15, 2, 11 p., 150.
Research output: Contribution to journal › Article › peer-review

Open Access
File
71 Downloads (Pure)
The Potential for Targeting G₂/M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy
Melia, E. & Parsons, J. L., 29 Aug 2024, In: Cancers. 16, 17, 3016.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
37 Downloads (Pure)