Developing Stem Cell Therapies for the Treatment of Inherited and Acquired Liver Disease

Research output

Research output per year 2014 2014 2017

• 5 Article

Research output per year

Research output per year

Search results

• 2017

  Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1

  Li, L., Zhang, Q., Yang, H., Zou, Q., Lai, C., Jiang, F., Zhao, P., Luo, Z., Yang, J., Chen, Q., Wang, Y., Newsome, P., Frampton, J., Maxwell, P. H., Li, W., Chen, S., Wang, D., Siu, T-S., Tam, S., Tse, H-F., & 4 othersQin, B., Bao, X., Esteban, M. A. & Lai, L., 17 Mar 2017, In: Journal of Biological Chemistry. 292, 11, p. 4755-4763 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • fumarylacetoacetate 100%
  • fumarylacetoacetase 86%
  • Tyrosinemias 76%
  • Tyrosine 45%
  • Mixed Function Oxygenases 43%
  10 Citations (Scopus)

  341 Downloads (Pure)
• 2015

  The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters

  Bao, X., Wu, H., Zhu, X., Guo, X., Hutchins, A. P., Luo, Z., Song, H., Chen, Y., Lai, K., Yin, M., Xu, L., Zhou, L., Chen, J., Wang, D., Qin, B., Frampton, J., Tse, H-F., Pei, D., Wang, H., Zhang, B., & 1 othersEsteban, M. A., Jan 2015, In: Cell Research. 25, 1, p. 80-92 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Cellular Reprogramming 100%
  • Untranslated RNA 88%
  • Methylation 70%
  • Methyltransferases 43%
  • Long Noncoding RNA 42%
  120 Citations (Scopus)
• 2014

  Generation of knockout rabbits using transcription activator-like effector nucleases

  Wang, Y., Fan, N., Song, J., Zhong, J., Guo, X., Tian, W., Zhang, Q., Cui, F., Li, L., Newsome, P. N., Frampton, J., Esteban, M. A. & Lai, L., 5 Feb 2014, In: Cell Regeneration . 3, 3.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcription Activator-Like Effector Nucleases 100%
  • Zinc Finger Nucleases 51%
  • Rabbits 47%
  • Gene Editing 40%
  • Gene Knockout Techniques 40%
  28 Citations (Scopus)

• RAG1/2 knockout pigs with severe combined immunodeficiency

  Huang, J., Guo, X., Fan, N., Song, J., Zhao, B., Ouyang, Z., Liu, Z., Zhao, Y., Yan, Q., Yi, X., Schambach, A., Frampton, J., Esteban, M. A., Yang, D., Yang, H. & Lai, L., 1 Aug 2014, In: Journal of Immunology. 193, 3, p. 1496-503 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Severe Combined Immunodeficiency 100%
  • Swine 61%
  • Transcription Activator-Like Effector Nucleases 47%
  • Mutation 35%
  • Biomedical Research 31%
  62 Citations (Scopus)

• Transcriptional pause release is a rate-limiting step for somatic cell reprogramming

  Liu, L., Xu, Y., He, M., Zhang, M., Cui, F., Lu, L., Yao, M., Tian, W., Benda, C., Zhuang, Q., Huang, Z., Li, W., Li, X., Zhao, P., Fan, W., Luo, Z., Li, Y., Wu, Y., Hutchins, A. P., Wang, D., & 12 othersTse, H-F., Schambach, A., Frampton, J., Qin, B., Bao, X., Yao, H., Zhang, B., Sun, H., Pei, D., Wang, H., Wang, J. & Esteban, M. A., 6 Nov 2014, In: Cell stem cell. 15, 5, p. 574-88 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Positive Transcriptional Elongation Factor B 100%
  • Cellular Reprogramming 76%
  • Chromatin Assembly and Disassembly 35%
  • RNA Polymerase II 34%
  • Genes 24%
  43 Citations (Scopus)