%PDF-1.3
%
1 0 obj
<<
/Metadata 2 0 R
/Names 3 0 R
/PageLabels 4 0 R
/Pages 5 0 R
/Type /Catalog
/AcroForm <<
/Fields [6 0 R]
/DA (/Helv 0 Tf 0 g )
/DR <<
/Font <<
/Helv 7 0 R
/ZaDb 8 0 R
>>
>>
>>
>>
endobj
9 0 obj
<<
/CreationDate (D:20191001111512+05'30')
/Creator (Arbortext Advanced Print Publisher 9.1.520/W Unicode)
/ModDate (D:20200720155225+01'00')
/Producer <4163726F6261742044697374696C6C65722031302E302E30202857696E646F7773293B206D6F646966696564207573696E6720695465787453686172709220352E352E313120A9323030302D323031372069546578742047726F7570204E5620284147504C2D76657273696F6E29>
/Title (c9an01421g 6048..6054 ++)
>>
endobj
2 0 obj
<<
/Length 4850
/Type /Metadata
/Subtype /XML
>>
stream
Nasser A. Alamrani, Gillian M. Greenway, Nicole Pamme, Nicholas J. Goddard, Ruchi Gupta
Analyst (2019), 144, 6048-6054, doi:10.1039/c9an01421g
Royal Society of Chemistry
This journal is © The Royal Society of Chemistry 2019
A feasibility study of a leaky waveguide aptasensor for thrombin
rsc.org
rsc.org
endstream
endobj
3 0 obj
<<
/Dests 10 0 R
>>
endobj
4 0 obj
<<
/Nums [0 11 0 R]
>>
endobj
5 0 obj
<<
/Count 8
/Kids [12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R]
/Type /Pages
>>
endobj
6 0 obj
<<
/FT /Btn
/Ff 65536
/Type /Annot
/Subtype /Widget
/Rect [42 621 141 640]
/T (Button 1)
/BS <<
/W 1
/S /S
>>
/AP <<
/N 20 0 R
>>
/DA (/Helv 0 Tf 0 g )
/F 4
/MK <<
/TP 0
/IF <<
>>
>>
/TU (Click for updates and to verify authenticity)
/A <<
/S /URI
/URI (http://crossmark.crossref.org/dialog/?doi=10.1039/c9an01421g&domain=pdf&date_stamp=2019-10-01)
>>
/P 13 0 R
/DR <<
/Font <<
/Helv 7 0 R
>>
>>
>>
endobj
7 0 obj
<<
/Type /Font
/Subtype /Type1
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
8 0 obj
<<
/Type /Font
/BaseFont /ZapfDingbats
/Name /ZaDb
/Subtype /Type1
>>
endobj
10 0 obj
<<
/Kids [21 0 R]
>>
endobj
11 0 obj
<<
/S /D
/St 6048
>>
endobj
12 0 obj
<<
/Contents 22 0 R
/Type /Page
/Resources <<
/Font <<
/F1 23 0 R
/F2 24 0 R
/F3 25 0 R
/F4 26 0 R
>>
/XObject <<
/Xf1 27 0 R
>>
>>
/Annots [28 0 R 29 0 R 30 0 R]
/Parent 5 0 R
/MediaBox [0 0 595 842]
>>
endobj
13 0 obj
<<
/Annots [31 0 R 32 0 R 33 0 R 34 0 R 6 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R]
/Contents [40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R]
/CropBox [0 0 595.276 779.528]
/MediaBox [0 0 595.276 779.528]
/Parent 5 0 R
/Resources <<
/ColorSpace <<
/Cs8 [/Indexed /DeviceCMYK 225 50 0 R]
>>
/ExtGState <<
/GS1 51 0 R
>>
/Font <<
/F1 52 0 R
/F10 53 0 R
/F11 54 0 R
/F12 55 0 R
/F13 56 0 R
/F2 57 0 R
/F3 58 0 R
/F4 59 0 R
/F5 60 0 R
/F6 61 0 R
/F7 62 0 R
/F8 63 0 R
/F9 64 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageI]
/XObject <<
/Im1 65 0 R
/Im2 66 0 R
/Im3 67 0 R
/Xi0 68 0 R
/Xi1 69 0 R
/Xi2 70 0 R
/Xi3 71 0 R
/Xi4 72 0 R
/Xi5 73 0 R
/Xi6 74 0 R
>>
>>
/Rotate 0
/Type /Page
>>
endobj
14 0 obj
<<
/Contents [75 0 R 76 0 R 77 0 R]
/CropBox [0 0 595.276 779.528]
/MediaBox [0 0 595.276 779.528]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS1 51 0 R
>>
/Font <<
/F1 52 0 R
/F10 53 0 R
/F11 54 0 R
/F12 55 0 R
/F13 56 0 R
/F14 78 0 R
/F15 79 0 R
/F4 59 0 R
/F6 61 0 R
/F7 62 0 R
/F8 63 0 R
/F9 64 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Xi7 68 0 R
/Xi8 69 0 R
/Xi9 70 0 R
/Xi10 71 0 R
/Xi11 80 0 R
>>
>>
/Rotate 0
/Type /Page
/Annots [81 0 R 82 0 R 83 0 R]
>>
endobj
15 0 obj
<<
/Contents [84 0 R 85 0 R 86 0 R]
/CropBox [0 0 595.276 779.528]
/MediaBox [0 0 595.276 779.528]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS1 51 0 R
>>
/Font <<
/F1 52 0 R
/F10 53 0 R
/F11 54 0 R
/F12 55 0 R
/F13 56 0 R
/F14 78 0 R
/F16 87 0 R
/F17 88 0 R
/F18 89 0 R
/F4 59 0 R
/F6 61 0 R
/F7 62 0 R
/F8 63 0 R
/F9 64 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/XObject <<
/Im4 90 0 R
/Xi12 68 0 R
/Xi13 69 0 R
/Xi14 70 0 R
/Xi15 71 0 R
/Xi16 80 0 R
>>
>>
/Rotate 0
/Type /Page
/Annots [91 0 R 92 0 R 93 0 R]
>>
endobj
16 0 obj
<<
/Contents [94 0 R 95 0 R 96 0 R]
/CropBox [0 0 595.276 779.528]
/MediaBox [0 0 595.276 779.528]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS1 51 0 R
>>
/Font <<
/F1 52 0 R
/F11 54 0 R
/F12 55 0 R
/F13 56 0 R
/F16 87 0 R
/F17 88 0 R
/F18 89 0 R
/F19 97 0 R
/F20 98 0 R
/F4 59 0 R
/F6 61 0 R
/F7 62 0 R
/F8 63 0 R
/F9 64 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/XObject <<
/Im5 99 0 R
/Xi17 68 0 R
/Xi18 69 0 R
/Xi19 70 0 R
/Xi20 71 0 R
/Xi21 80 0 R
>>
>>
/Rotate 0
/Type /Page
/Annots [100 0 R 101 0 R 102 0 R]
>>
endobj
17 0 obj
<<
/Contents [103 0 R 104 0 R 105 0 R]
/CropBox [0 0 595.276 779.528]
/MediaBox [0 0 595.276 779.528]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS1 51 0 R
>>
/Font <<
/F1 52 0 R
/F11 54 0 R
/F12 55 0 R
/F13 56 0 R
/F14 78 0 R
/F16 87 0 R
/F18 89 0 R
/F20 98 0 R
/F4 59 0 R
/F6 61 0 R
/F7 62 0 R
/F8 63 0 R
/F9 64 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/XObject <<
/Im6 106 0 R
/Im7 107 0 R
/Im8 108 0 R
/Xi22 68 0 R
/Xi23 69 0 R
/Xi24 70 0 R
/Xi25 71 0 R
/Xi26 80 0 R
>>
>>
/Rotate 0
/Type /Page
/Annots [109 0 R 110 0 R 111 0 R]
>>
endobj
18 0 obj
<<
/Contents [112 0 R 113 0 R 114 0 R]
/CropBox [0 0 595.276 779.528]
/MediaBox [0 0 595.276 779.528]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS1 51 0 R
>>
/Font <<
/F1 52 0 R
/F10 53 0 R
/F11 54 0 R
/F12 55 0 R
/F13 56 0 R
/F14 78 0 R
/F18 89 0 R
/F20 98 0 R
/F4 59 0 R
/F6 61 0 R
/F7 62 0 R
/F8 63 0 R
/F9 64 0 R
>>
/ProcSet [/PDF /Text /ImageB]
/XObject <<
/Im9 115 0 R
/Xi27 68 0 R
/Xi28 69 0 R
/Xi29 70 0 R
/Xi30 71 0 R
/Xi31 80 0 R
>>
>>
/Rotate 0
/Type /Page
/Annots [116 0 R 117 0 R 118 0 R]
>>
endobj
19 0 obj
<<
/Contents [119 0 R 120 0 R 121 0 R]
/CropBox [0 0 595.276 779.528]
/MediaBox [0 0 595.276 779.528]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS1 51 0 R
>>
/Font <<
/F1 52 0 R
/F10 53 0 R
/F11 54 0 R
/F12 55 0 R
/F13 56 0 R
/F14 78 0 R
/F4 59 0 R
/F7 62 0 R
/F8 63 0 R
/F9 64 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Xi32 68 0 R
/Xi33 69 0 R
/Xi34 70 0 R
/Xi35 71 0 R
/Xi36 80 0 R
>>
>>
/Rotate 0
/Type /Page
/Annots [122 0 R 123 0 R 124 0 R]
>>
endobj
20 0 obj
<<
/Length 12
/Type /XObject
/Subtype /Form
/Resources <<
/Font <<
/Helv 7 0 R
>>
>>
/BBox [0 0 99 19]
/FormType 1
/Matrix [1 0 0 1 0 0]
/Filter /FlateDecode
>>
stream
x+TT
endstream
endobj
21 0 obj
<<
/Limits [ ]
/Names [ 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R
130 0 R]
>>
endobj
22 0 obj
<<
/Length 1703
/Filter /FlateDecode
>>
stream
xX[sF;}kδM,d)]^dj$۾7]d;.\
kYnʲ
-])v@/ˢͪ
+(:}U ր*xUrMVZuHu臨d忀sp73{Z
]ɭ&$23
Ϻ6̀?ȌxxgɼV&;LspdLfq_ֲ]Wu\wغm<=4g=k٘8YwEkgcx0(#RrmzRkֹ'P}OqF= \:E.+rut:QJ*xPSgi&8s[]ѷz!Zu,Ìq/qMuoxz0jwK`l<l@ftͥrmT[~YA2>< >!g3\mci)NRHRD B~fTQJp~mѻEaEYMM<,A0ؼx~4%<92(j l`+C]6?ZikyGG+*;7UQ9E 9c3
wÏi/76vz%~=6]cu|ZT RS%MK36~5i(uqDk؛4.>/hvGK==i)HS|?;|bHtk Gn"-@'>⎼:!W'w{Ds)ͮs|b+f/+gfY Zm<;!\p!p4(^E,kW|Na \DD=[<#2'ء(Xx$M>DuLxUZEQV>H0 qɚVI>sAcSbF?VTa[͘F{QB
EWZgԾ.Fj1R,P<1Ą,gj60xiujr=8Z LZLqg"R4;&@+)F@W]T,CK֜@*QEq/5:_Ug
5?bvæ\joѥnVѷ#Xx@3BLCȮ)Mi=
T nxƊe%/u.rpC_PnFCn07МvE>)_fg{+Xyj.VchG2
endstream
endobj
23 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
24 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
25 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
26 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /UABSUM+LiberationSans
/Encoding /Identity-H
/DescendantFonts [131 0 R]
/ToUnicode 132 0 R
>>
endobj
27 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 133 0 R
>>
/Font <<
/F1 134 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
28 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1039/C9AN01421G)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 576 158.17 586]
>>
endobj
29 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1039/C9AN01421G)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [352.41 471 516.95 481]
>>
endobj
30 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/28021c46-1d6c-44f0-86f5-a7d744066f58)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 391 291.54 401]
>>
endobj
31 0 obj
<<
/A <<
/S /URI
/URI (www.rsc.li/analyst)
>>
/Border [0 0 0]
/Rect [42.52 417.43 79.767 424.686]
/Subtype /Link
/Type /Annot
>>
endobj
32 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0003-1873-8188)
>>
/Border [0 0 0]
/Rect [358.753 586.942 368.957 597.146]
/Subtype /Link
/Type /Annot
>>
endobj
33 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0002-9391-9387)
>>
/Border [0 0 0]
/Rect [447.704 586.942 457.965 597.146]
/Subtype /Link
/Type /Annot
>>
endobj
34 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0001-6456-8007)
>>
/Border [0 0 0]
/Rect [349.058 574.979 359.263 585.184]
/Subtype /Link
/Type /Annot
>>
endobj
35 0 obj
<<
/Subtype /Link
/Rect [14 289.76 26 353.76]
/A <<
/S /URI
/URI (http://creativecommons.org/licenses/by/3.0/)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
36 0 obj
<<
/Subtype /Link
/Rect [14 458.49 24 631.59]
/A <<
/S /URI
/URI (http://creativecommons.org/licenses/by/3.0/)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
37 0 obj
<<
/Subtype /Link
/Rect [452.41 676.53 535.28 687.53]
/A <<
/S /URI
/URI (https://doi.org/10.1039/c9an01421g)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
38 0 obj
<<
/Subtype /Link
/Rect [452.7 666.53 489.78 674.53]
/A <<
/S /URI
/URI (https://pubs.rsc.org/en/journals/journal/AN)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
39 0 obj
<<
/Subtype /Link
/Rect [490.7 666.53 525.78 674.53]
/A <<
/S /URI
/URI (https://pubs.rsc.org/en/journals/journal/AN?issueid=AN144020)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
40 0 obj
<<
/Length 10
/Filter /FlateDecode
>>
stream
x+ |
endstream
endobj
41 0 obj
<<
/Length 901
/Filter /FlateDecode
>>
stream
HUK6W(ܶݤH.M==7qfmo8d;@nY/lh8$e}0r4Mbsm~|GSG`φÇL`٤B6}0,76Rfc4길'!KGB<=ZPJ 5&g]Jp$bfs8h1eD SNE3PL1jWȒh()@ۙV=XrYY]՟[i0xI|ohFmpo͉1Bz?C]Et3@hi1yT֨ρE}.="a~
m_kE}]Ls>v˨cS9tjnwfGe\˅xlSvJ6KkRJ.)BuiC*%]|Φyn&ld͒Kb9xnf{ӱuy,d_P\-[]b~ݾ^l]l
-=?k*1ej%\Y 9[ x30*7/ޮ+7=pi)8).5â,/JV&]1uJB%!5YpV5 !Rp#gt쏟O+KV<ĞND8Т=Ccu".u @=;*Z!ͅVS6)]eMF j~J^
xe |c_
#OE+z%Q]v o>;yp0NBD>e
cAO*kÉY]4(=
z/]0p>6j}"4+v(S0O\nɛ)
H\@/Ql T:
endstream
endobj
42 0 obj
<<
/Length 1028
/Filter /FlateDecode
>>
stream
HUn6Eѷ
=RE~ythm!I+bֆ>3v}KgΜ9s̪f@.a5:s}\JY\sG%Y]2Tt}o!jՂM[n 7HsZÇ4՟V]pʅU ]uO4l㘃*+^5(cW~Ngn\J;Kjg;ZC-%!vj&gTysNC1О2]=ɜk* a/3 WqXx"\݅0j#q#L4TK0]I*T
z6o~n^"-qV[swi
]
ez=^+>j*pg}ڷ3"Fͽ#WZP
x9S>C~sS{s1}w
$*aω eK]f͋&w%֟b˚?REG`X1aB;X,K]