%PDF-1.4
%
1 0 obj
<<
/Names 2 0 R
/Metadata 3 0 R
/Type /Catalog
/Outlines 4 0 R
/PageLabels 5 0 R
/Pages 6 0 R
>>
endobj
7 0 obj
<<
/ModDate (D:20190121034115-08'00')
/Creator (Arbortext Advanced Print Publisher 9.1.510/W Unicode)
/CreationDate (D:20190116032723+05'30')
/Producer (Acrobat Distiller 10.0.0 \(Windows\); modified using iText 4.2.0 by 1T3XT)
/Subject (JCO 0.0:JCO.18.00889)
/Author (Charles Craddock, Daniel Slade, Carmela De Santo, Rachel Wheat, Paul Ferguson, Andrea Hodgkinson, Kristian Brock, Jamie Cavenagh, Wendy Ingram, Mike Dennis, Ram Malladi, Shamyla Siddique, Francis Mussai, and Christina Yap)
/Title (Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia)
>>
endobj
2 0 obj
<<
/Dests 8 0 R
>>
endobj
3 0 obj
<<
/Length 3697
/Subtype /XML
/Type /Metadata
>>
stream
doi:10.1200/JCO.18.00889
Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia
10.1200/JCO.18.00889
http://dx.doi.org/10.1200/JCO.18.00889
2019-01-16
false
10.1200/JCO.18.00889
http://ascopubs.org/
http://ascopubs.org/
10.1200/JCO.18.00889
2019-01-16
false
http://ascopubs.org/
endstream
endobj
4 0 obj
<<
/Count 1
/First 9 0 R
/Last 9 0 R
>>
endobj
5 0 obj
<<
/Nums [0 10 0 R]
>>
endobj
6 0 obj
<<
/Kids [11 0 R 12 0 R]
/Type /Pages
/Count 15
/ITXT (4.2.0)
>>
endobj
8 0 obj
<<
/Kids [13 0 R 14 0 R]
>>
endobj
9 0 obj
<<
/Dest
/Count -7
/Title
/Parent 4 0 R
/First 15 0 R
/Last 16 0 R
>>
endobj
10 0 obj
<<
/S /D
>>
endobj
11 0 obj
<<
/Kids [17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R
27 0 R]
/Type /Pages
/Count 11
/Parent 6 0 R
>>
endobj
12 0 obj
<<
/Kids [28 0 R 29 0 R 30 0 R 31 0 R]
/Type /Pages
/Count 4
/Parent 6 0 R
>>
endobj
13 0 obj
<<
/Names [ 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R
37 0 R 38 0 R 39 0 R 40 0 R 41 0 R
42 0 R 43 0 R 44 0 R 45 0 R 46 0 R
47 0 R 48 0 R 49 0 R 50 0 R 51 0 R
52 0 R 53 0 R 54 0 R 55 0 R 56 0 R
57 0 R 58 0 R 59 0 R 60 0 R 61 0 R
62 0 R 63 0 R 64 0 R 65 0 R 66 0 R
67 0 R 68 0 R 69 0 R 70 0 R 71 0 R
72 0 R 73 0 R 74 0 R 75 0 R 76 0 R
77 0 R 78 0 R 79 0 R 80 0 R 81 0 R
82 0 R 83 0 R 84 0 R 85 0 R 86 0 R
87 0 R 88 0 R 89 0 R 90 0 R 91 0 R
92 0 R 93 0 R 94 0 R 74 0 R]
/Limits [ ]
>>
endobj
14 0 obj
<<
/Names [ 76 0 R 74 0 R 95 0 R 95 0 R 75 0 R
75 0 R 75 0 R 75 0 R 75 0 R 73 0 R]
/Limits [ ]
>>
endobj
15 0 obj
<<
/Dest
/Next 96 0 R
/Parent 9 0 R
/Title
>>
endobj
16 0 obj
<<
/Dest
/Parent 9 0 R
/Title
/Prev 97 0 R
>>
endobj
17 0 obj
<<
/Contents 98 0 R
/Type /Page
/Resources <<
/Font <<
/F1 99 0 R
/F2 100 0 R
/F3 101 0 R
/F4 102 0 R
>>
/XObject <<
/Xf1 103 0 R
>>
>>
/Annots [104 0 R 105 0 R 106 0 R]
/Parent 11 0 R
/MediaBox [0 0 595 842]
>>
endobj
18 0 obj
<<
/Thumb 107 0 R
/Contents [108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs11 [/Separation /PANTONE#20Cool#20Gray#208#20C [/ICCBased 118 0 R]
119 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 122 0 R
/GS2 123 0 R
>>
/Font <<
/F7 124 0 R
/F8 125 0 R
/F9 126 0 R
/F1 127 0 R
/F2 128 0 R
/F3 129 0 R
/F4 130 0 R
/F5 131 0 R
/F6 132 0 R
>>
/XObject <<
/Xi0 133 0 R
/Xi1 134 0 R
>>
/Properties <<
/MC7 135 0 R
/MC8 136 0 R
/MC5 137 0 R
/MC6 138 0 R
/MC3 139 0 R
/MC4 140 0 R
/MC1 141 0 R
/MC2 142 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Annots [143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R
153 0 R 154 0 R 155 0 R 156 0 R]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
19 0 obj
<<
/Thumb 157 0 R
/Contents [158 0 R 159 0 R 160 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
/Cs13 [/Separation /PANTONE#20Cool#20Gray#203#20C [/ICCBased 118 0 R]
161 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 122 0 R
/GS2 123 0 R
>>
/Font <<
/F7 124 0 R
/F10 162 0 R
/F2 128 0 R
/F3 129 0 R
/F4 130 0 R
/F5 131 0 R
>>
/XObject <<
/Xi2 163 0 R
/Xi3 164 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Annots [165 0 R 166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R
175 0 R 176 0 R]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
20 0 obj
<<
/Thumb 177 0 R
/Contents [178 0 R 179 0 R 180 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 123 0 R
/GS3 181 0 R
/GS4 182 0 R
>>
/Font <<
/F7 124 0 R
/F10 162 0 R
/F11 183 0 R
/F2 128 0 R
/F3 129 0 R
/F4 130 0 R
/F5 131 0 R
/F12 184 0 R
>>
/XObject <<
/Xi4 185 0 R
/Xi5 186 0 R
>>
/Properties <<
/MC9 187 0 R
/MC10 188 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Annots [189 0 R 190 0 R 191 0 R 192 0 R]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
21 0 obj
<<
/Thumb 193 0 R
/Contents [194 0 R 195 0 R 196 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
/Cs13 [/Separation /PANTONE#20Cool#20Gray#203#20C [/ICCBased 118 0 R]
161 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 122 0 R
/GS2 123 0 R
>>
/Font <<
/F7 124 0 R
/F10 162 0 R
/F2 128 0 R
/F3 129 0 R
/F4 130 0 R
/F5 131 0 R
/F13 197 0 R
>>
/XObject <<
/Xi6 198 0 R
/Xi7 199 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Annots [200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R 206 0 R]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
22 0 obj
<<
/Thumb 207 0 R
/Contents [208 0 R 209 0 R 210 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
/Cs13 [/Separation /PANTONE#20Cool#20Gray#203#20C [/ICCBased 118 0 R]
161 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 122 0 R
/GS2 123 0 R
>>
/Font <<
/F7 124 0 R
/F10 162 0 R
/F2 128 0 R
/F3 129 0 R
/F4 130 0 R
/F5 131 0 R
/F6 132 0 R
/F13 197 0 R
>>
/XObject <<
/Xi8 211 0 R
/Xi9 212 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Annots [213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
23 0 obj
<<
/Thumb 223 0 R
/Contents [224 0 R 225 0 R 226 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 123 0 R
/GS3 181 0 R
/GS4 182 0 R
>>
/Font <<
/F11 183 0 R
/TT1 227 0 R
/F16 228 0 R
/F2 128 0 R
/F14 229 0 R
/F4 130 0 R
/F15 230 0 R
/F6 132 0 R
>>
/XObject <<
/Xi10 231 0 R
/Xi11 232 0 R
>>
/Properties <<
/MC12 233 0 R
/MC11 234 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
24 0 obj
<<
/Thumb 235 0 R
/Contents [236 0 R 237 0 R 238 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 123 0 R
>>
/Font <<
/F7 124 0 R
/F2 128 0 R
/F4 130 0 R
/F5 131 0 R
/F6 132 0 R
>>
/XObject <<
/Xi13 239 0 R
/Xi12 240 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Annots [241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R 250 0 R
251 0 R 252 0 R 253 0 R]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
25 0 obj
<<
/Thumb 254 0 R
/Contents [255 0 R 256 0 R 257 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs11 [/Separation /PANTONE#20Cool#20Gray#208#20C [/ICCBased 118 0 R]
119 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 123 0 R
>>
/Font <<
/F7 124 0 R
/F10 162 0 R
/F8 125 0 R
/F2 128 0 R
/F17 258 0 R
/F4 130 0 R
/F5 131 0 R
>>
/XObject <<
/Xi15 259 0 R
/Xi14 260 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Annots [261 0 R 262 0 R 263 0 R]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
26 0 obj
<<
/Thumb 264 0 R
/Contents [265 0 R 266 0 R 267 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 122 0 R
/GS2 123 0 R
>>
/Font <<
/F18 268 0 R
/F2 128 0 R
/F4 130 0 R
/F5 131 0 R
/F13 197 0 R
>>
/XObject <<
/Xi17 269 0 R
/Xi16 270 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
27 0 obj
<<
/Thumb 271 0 R
/Contents [272 0 R 273 0 R 274 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 123 0 R
>>
/Font <<
/F7 124 0 R
/F20 275 0 R
/F19 276 0 R
/F2 128 0 R
/F3 129 0 R
/F4 130 0 R
/F5 131 0 R
>>
/XObject <<
/Xi19 277 0 R
/Xi18 278 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Annots [279 0 R 280 0 R]
/Parent 11 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
28 0 obj
<<
/Thumb 281 0 R
/Contents [282 0 R 283 0 R 284 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 122 0 R
/GS2 123 0 R
/GS3 181 0 R
/GS4 182 0 R
>>
/Font <<
/F11 183 0 R
/F2 128 0 R
/F14 229 0 R
/F4 130 0 R
/F5 131 0 R
>>
/XObject <<
/Xi21 285 0 R
/Xi20 286 0 R
>>
/Properties <<
/MC13 287 0 R
/MC14 288 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Parent 12 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
29 0 obj
<<
/Thumb 289 0 R
/Contents [290 0 R 291 0 R 292 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 123 0 R
/GS3 181 0 R
/GS4 182 0 R
>>
/Font <<
/F11 183 0 R
/F2 128 0 R
/F14 229 0 R
/F4 130 0 R
/F13 197 0 R
>>
/XObject <<
/Xi23 293 0 R
/Xi22 294 0 R
>>
/Properties <<
/MC16 295 0 R
/MC17 296 0 R
/MC15 297 0 R
/MC18 298 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Parent 12 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
30 0 obj
<<
/Thumb 299 0 R
/Contents [300 0 R 301 0 R 302 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 123 0 R
/GS3 181 0 R
/GS4 182 0 R
>>
/Font <<
/F11 183 0 R
/F2 128 0 R
/F14 229 0 R
/F4 130 0 R
/F15 230 0 R
/F5 131 0 R
>>
/XObject <<
/Xi25 303 0 R
/Xi24 304 0 R
>>
/Properties <<
/MC20 305 0 R
/MC19 306 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Parent 12 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
31 0 obj
<<
/Thumb 307 0 R
/Contents [308 0 R 309 0 R 310 0 R]
/Type /Page
/Resources <<
/ColorSpace <<
/Cs10 [/ICCBased 118 0 R]
/Cs9 [/ICCBased 120 0 R]
/DefaultCMYK [/ICCBased 118 0 R]
/Cs12 [/Separation /PANTONE#207690#20C [/ICCBased 118 0 R]
121 0 R]
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 123 0 R
/GS3 181 0 R
/GS4 182 0 R
>>
/Font <<
/F21 311 0 R
/F22 312 0 R
/F11 183 0 R
/F2 128 0 R
/F4 130 0 R
/F5 131 0 R
>>
/XObject <<
/Xi27 313 0 R
/Xi26 314 0 R
>>
/Properties <<
/MC21 315 0 R
/MC22 316 0 R
>>
>>
/CropBox [0 0 584.9569702148 782.9860229492]
/Parent 12 0 R
/Rotate 0
/MediaBox [0 0 584.9569702148 782.9860229492]
>>
endobj
32 0 obj
<<
/D [25 0 R /FitR 78 419 549 419]
>>
endobj
33 0 obj
<<
/D [25 0 R /FitR 78 236 549 236]
>>
endobj
34 0 obj
<<
/D [25 0 R /FitR 78 217 549 217]
>>
endobj
35 0 obj
<<
/D [25 0 R /FitR 78 197 549 197]
>>
endobj
36 0 obj
<<
/D [25 0 R /FitR 78 178 549 178]
>>
endobj
37 0 obj
<<
/D [25 0 R /FitR 78 158 549 158]
>>
endobj
38 0 obj
<<
/D [25 0 R /FitR 78 139 549 139]
>>
endobj
39 0 obj
<<
/D [25 0 R /FitR 78 120 549 120]
>>
endobj
40 0 obj
<<
/D [25 0 R /FitR 78 109 549 109]
>>
endobj
41 0 obj
<<
/D [25 0 R /FitR 78 89 549 89]
>>
endobj
42 0 obj
<<
/D [26 0 R /FitR 78 743 549 743]
>>
endobj
43 0 obj
<<
/D [25 0 R /FitR 78 400 549 400]
>>
endobj
44 0 obj
<<
/D [26 0 R /FitR 78 724 549 724]
>>
endobj
45 0 obj
<<
/D [26 0 R /FitR 78 704 549 704]
>>
endobj
46 0 obj
<<
/D [26 0 R /FitR 78 685 549 685]
>>
endobj
47 0 obj
<<
/D [26 0 R /FitR 78 665 549 665]
>>
endobj
48 0 obj
<<
/D [26 0 R /FitR 78 654 549 654]
>>
endobj
49 0 obj
<<
/D [26 0 R /FitR 78 635 549 635]
>>
endobj
50 0 obj
<<
/D [26 0 R /FitR 78 616 549 616]
>>
endobj
51 0 obj
<<
/D [26 0 R /FitR 78 596 549 596]
>>
endobj
52 0 obj
<<
/D [26 0 R /FitR 78 577 549 577]
>>
endobj
53 0 obj
<<
/D [26 0 R /FitR 78 557 549 557]
>>
endobj
54 0 obj
<<
/D [25 0 R /FitR 78 381 549 381]
>>
endobj
55 0 obj
<<
/D [25 0 R /FitR 78 361 549 361]
>>
endobj
56 0 obj
<<
/D [25 0 R /FitR 78 333 549 333]
>>
endobj
57 0 obj
<<
/D [25 0 R /FitR 78 314 549 314]
>>
endobj
58 0 obj
<<
/D [25 0 R /FitR 78 294 549 294]
>>
endobj
59 0 obj
<<
/D [25 0 R /FitR 78 275 549 275]
>>
endobj
60 0 obj
<<
/D [25 0 R /FitR 78 256 549 256]
>>
endobj
61 0 obj
<<
/D [20 0 R /FitR 40 141 546 141]
>>
endobj
62 0 obj
<<
/D [23 0 R /FitR 71 158 515 158]
>>
endobj
63 0 obj
<<
/D [28 0 R /FitR 61 344 285 344]
>>
endobj
64 0 obj
<<
/D [29 0 R /FitR 43 672 543 672]
>>
endobj
65 0 obj
<<
/D [29 0 R /FitR 100 130 486 130]
>>
endobj
66 0 obj
<<
/D [30 0 R /FitR 410 728 549 728]
>>
endobj
67 0 obj
<<
/D [31 0 R /FitR 55 378 531 378]
>>
endobj
68 0 obj
<<
/D [19 0 R /FitR 78 248 549 248]
>>
endobj
69 0 obj
<<
/D [21 0 R /FitR 318 745 549 745]
>>
endobj
70 0 obj
<<
/D [22 0 R /FitR 37 744 549 744]
>>
endobj
71 0 obj
<<
/D [22 0 R /FitR 37 227 549 227]
>>
endobj
72 0 obj
<<
/D [28 0 R /FitR 0 783 585 783]
>>
endobj
73 0 obj
<<
/D [18 0 R /FitR 0 783 585 783]
>>
endobj
74 0 obj
<<
/D [19 0 R /FitR 0 783 585 783]
>>
endobj
75 0 obj
<<
/D [21 0 R /FitR 0 783 585 783]
>>
endobj
76 0 obj
<<
/D [22 0 R /FitR 0 783 585 783]
>>
endobj
77 0 obj
<<
/D [27 0 R /FitR 0 783 585 783]
>>
endobj
78 0 obj
<<
/D [25 0 R /FitR 0 783 585 783]
>>
endobj
79 0 obj
<<
/D [18 0 R /FitR 115 271 327 271]
>>
endobj
80 0 obj
<<
/D [21 0 R /FitR 78 406 308 406]
>>
endobj
81 0 obj
<<
/D [21 0 R /FitR 78 195 308 195]
>>
endobj
82 0 obj
<<
/D [21 0 R /FitR 318 167 549 167]
>>
endobj
83 0 obj
<<
/D [22 0 R /FitR 78 378 308 378]
>>
endobj
84 0 obj
<<
/D [22 0 R /FitR 318 344 549 344]
>>
endobj
85 0 obj
<<
/D [25 0 R /FitR 318 680 549 680]
>>
endobj
86 0 obj
<<
/D [19 0 R /FitR 78 334 308 334]
>>
endobj
87 0 obj
<<
/D [19 0 R /FitR 78 318 308 318]
>>
endobj
88 0 obj
<<
/D [19 0 R /FitR 318 585 549 585]
>>
endobj
89 0 obj
<<
/D [25 0 R /FitR 318 744 549 744]
>>
endobj
90 0 obj
<<
/D [20 0 R /FitR 78 745 308 745]
>>
endobj
91 0 obj
<<
/D [20 0 R /FitR 318 665 549 665]
>>
endobj
92 0 obj
<<
/D [21 0 R /FitR 78 745 308 745]
>>
endobj
93 0 obj
<<
/D [21 0 R /FitR 78 549 308 549]
>>
endobj
94 0 obj
<<
/D [21 0 R /FitR 78 534 308 534]
>>
endobj
95 0 obj
<<
/D [20 0 R /FitR 0 783 585 783]
>>
endobj
96 0 obj
<<
/Dest
/Count -5
/Next 317 0 R
/Title
/Parent 9 0 R
/First 318 0 R
/Prev 15 0 R
/Last 319 0 R
>>
endobj
97 0 obj
<<
/Dest
/Next 16 0 R
/Title
/Parent 9 0 R
/Prev 320 0 R
>>
endobj
98 0 obj
<<
/Length 1936
/Filter /FlateDecode
>>
stream
xXsHVTykwgT)X1KB"ݹ0_)lYju|%&1aE+rxhvH
xpQ]Kk>=LM
6Oȉea$7
uLIY䅄VGG<X#"ڎ'\,i}1iFڌi0F+32[2dDK1â&?K`"^-x/b`Sq848ϐb>]qvFEDW:{ur͟XW OyRC^Dbכ8`;`HjJivNͬ0:יFݴMnݪsbT9bJ~)9l\A|JΓ$_6HŇÇjGafłLE߄A
2%dqH׀8,:2b0}q^D6crge}F4>T#hp~zx4=߅eӎ,{kO4o6}hzI[5lc>|"?3[:yб,Bxgz3]0r|Pc@/$#Puc"r8a
B[J7 #/Wq!<iI:X~ A|N0!З}9D'AX'4ŴQQt^AMۮ,ĿLu|zx腼F?S
LSIBcs 0Xh4_U~+^]0Pb@h@5Ws6OMkï
xx3ԁ+i]};x+>9ix~f/$,9-},hv/'hn#FuC2.L!F,L0nqX!N{m;>Y%ǻ*OFu\嶧'c3|pa#y7]na졁BW*3'!v|IL0ef#I
LcL
#7-a@f=C_8`^{[jоes9o~OU!dr
kwg%2+5,Y.hWQ4JF-)֥ZKB[xC=1#dBLE'<.S.rK%{؞!a&Q'G|0[Re>we5ң.\ocʖJn1䪓6hjZG>B&Q\:p,H
Fo6֠ll+7aLnE(;DB9iGJ\0/R##Ez+jbFiFr1lYߔ(.tv뽺( R&<ͼ )͗SȖ+W>'QfV)Ezbwrm쎋;Dd
Bv^)4o#ʔ
}b!_M|v:OP);Q)eB[mnN
8+eLNc B˲e}VĶ*=0&O50Ss툲2D+!MeE1pt`UU5+e~R6x&t,j>
mCyisaJLj?BHMZiGK·8-vr!ׂnvdwv>l*Nvw.H1?#6CUFTu0DwhT~=.5C&l5;Z? [5
endstream
endobj
99 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
100 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
101 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
102 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /MVUJOX+LiberationSans
/Encoding /Identity-H
/DescendantFonts [321 0 R]
/ToUnicode 322 0 R
>>
endobj
103 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 323 0 R
>>
/Font <<
/F1 324 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
104 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1200/JCO.18.00889)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 585 160.4 595]
>>
endobj
105 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1200/JCO.18.00889)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 450 223.77 460]
>>
endobj
106 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/ad0ed775-ecfc-4589-bee2-77d7ca72be8d)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 400 291.54 410]
>>
endobj
107 0 obj
<<
/Length 731
/ColorSpace [/Indexed /DeviceRGB 255 325 0 R]
/Height 97
/Filter [/ASCII85Decode /FlateDecode]
/Width 73
/BitsPerComponent 8
>>
stream
8;Z\78Wn`L&G/;BI?E!k_P=%!+o!*b=l1+4P0H+)+lho
n7_J>E_@amkaLBjVm=O4X25!UC>?HXu69?fa
U(bX],L,10E\l!t+*alB>0eqT7;r72&?B%O'RN7*6^:cHlT/uL;mnhs06[.t)d&7+
(_*&^3Gf^U]b$P;U1O\;XZ8ZuYFN`O?UW9,;n-<^-W7bC+Gh$9YN7QG'BJT\-E/T!
;Ca3MG=+EqVn/5B1Q]6gSa#*+]9!-@UBNZ\5s>f1hC22I3,ic
1hpiN0ni+PDj$P(eOhJU%OTK$,LZA[GkX6SMEFamCtC>-POL\e:J
ntF\a9%-ue]hA*-*>5)A&c'0-'d4'>O!\:f>+fD2
@)RU+i]A:\=*u^u8)O%O:@'YC5;3KGlYhFBm8ca<@Y^S#bN>d(T=%Uh>PQQFq\oN8AE)b~>
endstream
endobj
108 0 obj
<<
/Length 10
/Filter /FlateDecode
>>
stream
x+ |
endstream
endobj
109 0 obj
<<
/Length 1609
/Filter /FlateDecode
>>
stream
HWr6}W𑚉`\ }rmZnN䁡hD9=.=V'o6_^mM^''K2,}&`0U e3!7&ﮞ|ɼ"Ld}K]9>"\0NjJ
9U(Uf$N$ˬDα,&NHTE(AYb$ç\Mćn&<}rx)<3EăA)fd?L@&2vLyE"XdCF(sT
9؎
fżH&s#ݑ *
?i
rqxɼ7YâjP8bq2m Ae3m
Q1BBT _?eHό
HQ0*ŰA"{mM dR#ou3ENK+rU-!O-!(tV")2 G:iJkX*nyP3D-*(X||̷]sݴz:N"m~^-mI. h!Ҽ-$U%lq1o7_`blL&v,]O-f,