%PDF-1.4
%
1 0 obj
<<
/Metadata 2 0 R
/Names 3 0 R
/Outlines 4 0 R
/Pages 5 0 R
/Type /Catalog
/ViewerPreferences <<
/Direction /L2R
>>
>>
endobj
6 0 obj
<<
/CreationDate (D:20181031054809Z)
/Creator (Adobe InDesign CS6 \(Windows\))
/ModDate (D:20181217030728-08'00')
/Producer (Adobe PDF Library 10.0.1)
/Trapped /False
/jobID (43385a03-f313-4f2b-a108-b07c7d9d43e6)
>>
endobj
2 0 obj
<<
/Length 2888
/Subtype /XML
/Type /Metadata
>>
stream
doi:bmjopen-2018-023386
application/pdf
2018-10-31T05:48:09Z
2018-12-17T03:07:28-08:00
2018-12-17T03:07:28-08:00
Adobe InDesign CS6 (Windows)
uuid:74709bb6-1dd2-11b2-0a00-c900889ca0ff
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
xmp.id:FC3D7A8AD0DCE811B6B6D4E65AC50A8C
proof:pdf
xmp.iid:FB3D7A8AD0DCE811B6B6D4E65AC50A8C
xmp.did:12BEE6AC550DE8118634A2E26D244B8E
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
default
converted
from application/x-indesign to application/pdf
Adobe InDesign CS6 (Windows)
/
2018-10-31T05:48:09Z
43385a03-f313-4f2b-a108-b07c7d9d43e6
Adobe PDF Library 10.0.1
False
endstream
endobj
3 0 obj
<<
/Dests 7 0 R
>>
endobj
4 0 obj
<<
/Count 14
/First 8 0 R
/Last 8 0 R
/Type /Outlines
>>
endobj
5 0 obj
<<
/Count 6
/Kids [9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R]
/Type /Pages
>>
endobj
7 0 obj
<<
/Names [(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:BLK_BX1:2104) [10 0 R /XYZ 387 575 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:BLK_T2:2103) [12 0 R /XYZ 48 160 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 10:2114) [12 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 11:2115) [12 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 12:2116) [13 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 13:2117) [13 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 14:2118) [14 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 1:2105) [10 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 2:2106) [10 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 3:2107) [10 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 4:2108) [11 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 5:2109) [11 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 6:2110) [11 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 7:2111) [11 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 8:2112) [11 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 9:2113) [11 0 R /Fit]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R10:2059) [14 0 R /XYZ 306 569 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R11:2060) [14 0 R /XYZ 306 552 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R12:2061) [14 0 R /XYZ 306 527 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R13:2062) [14 0 R /XYZ 306 510 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R14:2063) [14 0 R /XYZ 306 476 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R15:2064) [14 0 R /XYZ 306 450 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R16:2065) [14 0 R /XYZ 306 425 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R17:2066) [14 0 R /XYZ 306 399 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R18:2067) [14 0 R /XYZ 306 374 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R19:2068) [14 0 R /XYZ 306 357 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R1:2050) [14 0 R /XYZ 40 153 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R20:2069) [14 0 R /XYZ 306 323 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R21:2070) [14 0 R /XYZ 306 306 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R22:2071) [14 0 R /XYZ 306 280 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R23:2072) [14 0 R /XYZ 306 255 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R24:2073) [14 0 R /XYZ 306 229 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R25:2074) [14 0 R /XYZ 306 195 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R26:2075) [14 0 R /XYZ 306 178 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R27:2076) [14 0 R /XYZ 306 144 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R2:2051) [14 0 R /XYZ 40 136 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R3:2052) [14 0 R /XYZ 306 748 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R4:2053) [14 0 R /XYZ 306 722 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R5:2054) [14 0 R /XYZ 306 697 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R6:2055) [14 0 R /XYZ 306 680 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R7:2056) [14 0 R /XYZ 306 654 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R8:2057) [14 0 R /XYZ 306 620 null]
(43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:R9:2058) [14 0 R /XYZ 306 595 null]
]
>>
endobj
8 0 obj
<<
/A 15 0 R
/Count 13
/First 16 0 R
/Last 17 0 R
/Parent 4 0 R
/Title
>>
endobj
9 0 obj
<<
/Contents 18 0 R
/Type /Page
/Resources <<
/Font <<
/F1 19 0 R
/F2 20 0 R
/F3 21 0 R
/F4 22 0 R
>>
/XObject <<
/Xf1 23 0 R
>>
>>
/Annots [24 0 R 25 0 R 26 0 R]
/Parent 5 0 R
/MediaBox [0 0 595 842]
>>
endobj
10 0 obj
<<
/Annots [27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R
37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 43 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 44 0 R
/GS1 45 0 R
/GS2 46 0 R
>>
/Font <<
/C2_0 47 0 R
/T1_0 48 0 R
/T1_1 49 0 R
/T1_2 50 0 R
/T1_3 51 0 R
/T1_4 52 0 R
/T1_5 53 0 R
/T1_6 54 0 R
/T1_7 55 0 R
/TT0 56 0 R
>>
/ProcSet [/PDF /Text]
/Properties <<
/MC0 57 0 R
/MC1 58 0 R
/MC2 59 0 R
>>
/Shading <<
/Sh0 60 0 R
>>
/XObject <<
/Fm0 61 0 R
/Fm1 62 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
11 0 obj
<<
/Annots [63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R
73 0 R 74 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 75 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 44 0 R
/GS1 76 0 R
/GS2 77 0 R
>>
/Font <<
/T1_0 48 0 R
/T1_1 49 0 R
/T1_2 54 0 R
/T1_3 78 0 R
/T1_4 55 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 79 0 R
/Fm1 80 0 R
/Fm2 62 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
12 0 obj
<<
/Annots [81 0 R 82 0 R 83 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 84 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 44 0 R
/GS1 85 0 R
/GS2 86 0 R
/GS3 87 0 R
/GS4 88 0 R
>>
/Font <<
/T1_0 48 0 R
/T1_1 49 0 R
/T1_2 54 0 R
/T1_3 50 0 R
/T1_4 55 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 89 0 R
/Fm1 90 0 R
/Fm2 62 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
13 0 obj
<<
/Annots [91 0 R 92 0 R 93 0 R 94 0 R 95 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 96 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 44 0 R
/GS1 97 0 R
/GS2 98 0 R
>>
/Font <<
/T1_0 48 0 R
/T1_1 49 0 R
/T1_2 54 0 R
/T1_3 55 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 79 0 R
/Fm1 80 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
14 0 obj
<<
/Annots [99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R
109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R
119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 129 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 44 0 R
/GS1 130 0 R
/GS2 131 0 R
>>
/Font <<
/T1_0 48 0 R
/T1_1 49 0 R
/T1_2 54 0 R
/T1_3 52 0 R
/T1_4 50 0 R
/T1_5 132 0 R
/T1_6 55 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 133 0 R
/Fm1 134 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
15 0 obj
<<
/D (43385a03-f313-4f2b-a108-b07c7d9d43e6.indd:Bookmark 1:2105)
/S /GoTo
>>
endobj
16 0 obj
<<
/A 135 0 R
/Next 136 0 R
/Parent 8 0 R
/Title
>>
endobj
17 0 obj
<<
/A 137 0 R
/Parent 8 0 R
/Prev 138 0 R
/Title
>>
endobj
18 0 obj
<<
/Length 1895
/Filter /FlateDecode
>>
stream
xX[sF2C6ӦI`,б 1w]( !;۾7]!tչ|;߮%TJYQ4:]ɥJk{/aZF3WCdF[0Ѐk*
J)tLUʮ.J"
Ww#ۺ5ݵ}%=ܥe_͍g0~m[/"ֵR)7^5l:3k,kMÝΩ1[Z:6uϲM5/0ul˳OzHW^̙Iq=nfߒsS<7ċn.eLù40hP.r9*6kJE?9SiiZS\\L6WTh[S^wRPgi Ugt=ٗg͙,MۣcFXN&۽s]nbkjSZqɝ%WZҧKW
{kɐˉ)H&g7#m1(> -ӿfu_Wnffẻ"K!khQ4oy̱{,W)*̾)1_`E\Ap9o]ͽ5 M8ti%n-FޒI
"'OF$&-8`:<1ȩmZ Q:y01Ճ%j!1!]3;c8jpu?ۤІ1G==x#zvBl&Vl+Vhatbב$,bnfq8c^zM56?=bhK!Z&vvw$!a%|Ƃج1N낡6A4h8T'1n
vafۢ}+48 K#88\HY+P?';f{MBm_ X'nNLhg1cdF3P2)}?yoaGx!ŧ[[Tzy|MT-|_}Ոx|"Seq(8zBdGY=h
*wW4;+~qe; ]T648%ܝ[]0GDc&%g;иJb}Ց
Z^GMYB2.uU