%PDF-1.7
%
1 0 obj
<<
/Metadata 2 0 R
/OpenAction <<
/D [3 0 R /FitH -32768]
/S /GoTo
>>
/PageLabels <<
/Kids [4 0 R 5 0 R 6 0 R]
>>
/PageLayout /SinglePage
/PageMode /UseThumbs
/Pages 7 0 R
/Type /Catalog
>>
endobj
8 0 obj
<<
/CreationDate (D:20180526175749+05'30')
/ElsevierWebPDFSpecifications (6.5)
/ModDate (D:20180526175750+05'30')
/Producer <695465787453686172709220352E352E313020A9323030302D323031362069546578742047726F7570204E5620284147504C2D76657273696F6E29>
/doi (10.1016/j.pharmthera.2018.05.011)
>>
endobj
2 0 obj
<<
/Length 4036
/Subtype /XML
/Type /Metadata
>>
stream
Elsevier
application/pdf
doi:10.1016/j.pharmthera.2018.05.011
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
Elsevier Inc
, Accepted manuscript. doi:10.1016/j.pharmthera.2018.05.011
Brice Korkmaz
George H. Caughey
Iain Chapple
Francis Gauthier
Josefine Hirschfeld
Dieter E. Jenne
Ralph Kettritz
Gilles Lalmanach
Anne-Sophie Lamort
Conni Lauritzen
Monika Legowska
Adam Lesner
Sylvain Marchand-Adam
Sarah J. McKaig
Celia Moss
John Pedersen
Helen Roberts
Adrian Schreiber
Seda Seren
Nalin S. Thakkar
Cathepsin C
Serine proteases
Papillon-Lefèvre syndrome
Inflammatory/autoimmune diseases
Therapeutic inhibitors
Pharmacological targeting
P
0163-7258
https://doi.org/10.1016/j.pharmthera.2018.05.011
10.1016/j.pharmthera.2018.05.011
© 2018 Elsevier Inc. All rights reserved.
journal
#pagerange#
#startpage#
2010-04-23
true
10.1016/j.pharmthera.2018.05.011
elsevier.com
sciencedirect.com
6.5
10.1016/j.pharmthera.2018.05.011
2010-04-23
true
sciencedirect.com
elsevier.com
True
endstream
endobj
3 0 obj
<<
/Annots [9 0 R 10 0 R]
/Contents 11 0 R
/MediaBox [0 0 612 792]
/Parent 12 0 R
/Resources <<
/Font <<
/F1 13 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/XObject <<
/I1 14 0 R
>>
>>
/Type /Page
>>
endobj
4 0 obj
<<
/Limits [0 63]
/Nums [0 15 0 R 1 16 0 R 2 17 0 R 3 18 0 R 4 19 0 R
5 20 0 R 6 21 0 R 7 22 0 R 8 23 0 R 9 24 0 R
10 25 0 R 11 26 0 R 12 27 0 R 13 28 0 R 14 29 0 R
15 30 0 R 16 31 0 R 17 32 0 R 18 33 0 R 19 34 0 R
20 35 0 R 21 36 0 R 22 37 0 R 23 38 0 R 24 39 0 R
25 40 0 R 26 41 0 R 27 42 0 R 28 43 0 R 29 44 0 R
30 45 0 R 31 46 0 R 32 47 0 R 33 48 0 R 34 49 0 R
35 50 0 R 36 51 0 R 37 52 0 R 38 53 0 R 39 54 0 R
40 55 0 R 41 56 0 R 42 57 0 R 43 58 0 R 44 59 0 R
45 60 0 R 46 61 0 R 47 62 0 R 48 63 0 R 49 64 0 R
50 65 0 R 51 66 0 R 52 67 0 R 53 68 0 R 54 69 0 R
55 70 0 R 56 71 0 R 57 72 0 R 58 73 0 R 59 74 0 R
60 75 0 R 61 76 0 R 62 77 0 R 63 78 0 R]
>>
endobj
5 0 obj
<<
/Limits [64 127]
/Nums [64 79 0 R 65 80 0 R 66 81 0 R 67 82 0 R 68 83 0 R
69 84 0 R 70 85 0 R 71 86 0 R 72 87 0 R 73 88 0 R
74 89 0 R 75 90 0 R 76 91 0 R 77 92 0 R 78 93 0 R
79 94 0 R 80 95 0 R 81 96 0 R 82 97 0 R 83 98 0 R
84 99 0 R 85 100 0 R 86 101 0 R 87 102 0 R 88 103 0 R
89 104 0 R 90 105 0 R 91 106 0 R 92 107 0 R 93 108 0 R
94 109 0 R 95 110 0 R 96 111 0 R 97 112 0 R 98 113 0 R
99 114 0 R 100 115 0 R 101 116 0 R 102 117 0 R 103 118 0 R
104 119 0 R 105 120 0 R 106 121 0 R 107 122 0 R 108 123 0 R
109 124 0 R 110 125 0 R 111 126 0 R 112 127 0 R 113 128 0 R
114 129 0 R 115 130 0 R 116 131 0 R 117 132 0 R 118 133 0 R
119 134 0 R 120 135 0 R 121 136 0 R 122 137 0 R 123 138 0 R
124 139 0 R 125 140 0 R 126 141 0 R 127 142 0 R]
>>
endobj
6 0 obj
<<
/Limits [128 145]
/Nums [128 143 0 R 129 144 0 R 130 145 0 R 131 146 0 R 132 147 0 R
133 148 0 R 134 149 0 R 135 150 0 R 136 151 0 R 137 152 0 R
138 153 0 R 139 154 0 R 140 155 0 R 141 156 0 R 142 157 0 R
143 158 0 R 144 159 0 R 145 160 0 R]
>>
endobj
7 0 obj
<<
/Count 147
/Kids [161 0 R 162 0 R]
/Type /Pages
>>
endobj
9 0 obj
<<
/A <<
/S /URI
/Type /Action
/URI (https://doi.org/10.1016/j.pharmthera.2018.05.011)
>>
/Border [0 0 0]
/Rect [235.5318 480.8555 401.3932 494.1445]
/Subtype /Link
/Type /Annot
>>
endobj
10 0 obj
<<
/A <<
/S /URI
/Type /Action
/URI (https://doi.org/10.1016/j.pharmthera.2018.05.011)
>>
/Border [0 0 0]
/Rect [293.3027 331.1555 459.1641 344.4445]
/Subtype /Link
/Type /Annot
>>
endobj
11 0 obj
<<
/Length 2346
/Filter /FlateDecode
>>
stream
xYMsIWCQsc``]ȥi[-Ax~e2ހYUeI g>|q߮.
<ɻ/"WˋB9xmvMڱ.\~U[.(>YwW<6ۼumrZ8kOvx}k[͗G7y7-Zja!82QHVy;u}^H)5$jaqT PD
baa=UaucnvåocZsn!3G"3!([Z U5J_eY;Y%b^ޢNFؤ5!5*$;Uݮsm)6lǯǦoiͱ~xm'V8P)_w=K/#Ʃ]]Zat˻㦎%9x]QASf]ըRW)mwۑ|;5*ݺ:O$}ءvE܌s#1];>Ù0ȡU:Kq/j`}9sgO?w_(S_f>}m "_,"?
+K+=-Uyߌʮf}T>y/wxmMwC|Z{]CYā