%PDF-1.4
%
1 0 obj
<<
/Metadata 2 0 R
/Type /Catalog
/Pages 3 0 R
>>
endobj
4 0 obj
<<
/ModDate (D:20171221065951-05'00')
/CreationDate (D:20171221065951-05'00')
/Producer (iText 4.2.0 by 1T3XT)
/Subject (J. Med. Chem. 0.0:null-null)
/Author (Wolfgang Dohle, Fabrice L Jourdan, Gregory Menchon, Andrea E. Prota, Paul A Foster, Pascoe Mannion, Ernest Hamel, Mark P Thomas, Philip G. Kasprzyk, Eric Ferrandis, Michel O. Steinmetz, Mathew P Leese, and Barry V. L. Potter)
/Title (Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure)
>>
endobj
2 0 obj
<<
/Length 3114
/Subtype /XML
/Type /Metadata
>>
stream
JAM
10.1021/acs.jmedchem.7b01474
AM
JAM10.1021/acs.jmedchem.7b01474AM
endstream
endobj
3 0 obj
<<
/Kids [5 0 R 6 0 R 7 0 R 8 0 R 9 0 R]
/Type /Pages
/Count 50
/ITXT (4.2.0)
>>
endobj
5 0 obj
<<
/Kids [10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R
20 0 R]
/Type /Pages
/Count 11
/Parent 3 0 R
>>
endobj
6 0 obj
<<
/Kids [21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R]
/Type /Pages
/Count 10
/Parent 3 0 R
>>
endobj
7 0 obj
<<
/Kids [31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R]
/Type /Pages
/Count 10
/Parent 3 0 R
>>
endobj
8 0 obj
<<
/Kids [41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R]
/Type /Pages
/Count 10
/Parent 3 0 R
>>
endobj
9 0 obj
<<
/Kids [51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R]
/Type /Pages
/Count 9
/Parent 3 0 R
>>
endobj
10 0 obj
<<
/Contents 60 0 R
/Type /Page
/Resources <<
/Font <<
/F1 61 0 R
/F2 62 0 R
/F3 63 0 R
/F4 64 0 R
>>
/XObject <<
/Xf1 65 0 R
>>
>>
/Annots [66 0 R 67 0 R 68 0 R]
/Parent 5 0 R
/MediaBox [0 0 595 842]
>>
endobj
11 0 obj
<<
/Contents 69 0 R
/BleedBox [0 0 612 792]
/Type /Page
/Resources 70 0 R
/CropBox [0 0 612 792]
/Parent 5 0 R
/MediaBox [0 0 612 792]
/TrimBox [0 0 612 792]
>>
endobj
12 0 obj
<<
/QInserted true
/Contents 71 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
13 0 obj
<<
/QInserted true
/Contents 77 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
14 0 obj
<<
/QInserted true
/Contents 79 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
15 0 obj
<<
/QInserted true
/Contents 80 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageB]
/Font <<
/T1_0 74 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
/XObject <<
/Im3 81 0 R
/Im1 82 0 R
/Im2 83 0 R
/Im0 84 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
16 0 obj
<<
/QInserted true
/Contents 85 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageB]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
17 0 obj
<<
/QInserted true
/Contents 87 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageB]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
18 0 obj
<<
/QInserted true
/Contents 88 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
19 0 obj
<<
/QInserted true
/Contents 89 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
20 0 obj
<<
/QInserted true
/Contents 90 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageB]
/Font <<
/T1_0 74 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
/XObject <<
/Im0 91 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 5 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
21 0 obj
<<
/QInserted true
/Contents 92 0 R
/Type /Page
/Resources <<
/ColorSpace <<
/CS1 [/Indexed /DeviceGray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
/CS0 [/Indexed /DeviceGray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
>>
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/Font <<
/T1_0 74 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
/XObject <<
/Im3 93 0 R
/Im4 94 0 R
/Im1 95 0 R
/Im2 96 0 R
/Im0 97 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
22 0 obj
<<
/QInserted true
/Contents 98 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Font <<
/T1_0 74 0 R
/TT1 78 0 R
/TT2 99 0 R
/TT0 76 0 R
>>
/XObject <<
/Im7 100 0 R
/Im5 101 0 R
/Im6 102 0 R
/Im3 103 0 R
/Im4 104 0 R
/Im1 105 0 R
/Im2 106 0 R
/Im0 107 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
23 0 obj
<<
/QInserted true
/Contents 108 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 99 0 R
/TT0 76 0 R
>>
/XObject <<
/Im1 109 0 R
/Im2 110 0 R
/Im0 111 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
24 0 obj
<<
/QInserted true
/Contents 112 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Font <<
/T1_0 74 0 R
/TT3 99 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
/XObject <<
/Im1 113 0 R
/Im2 114 0 R
/Im0 115 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
25 0 obj
<<
/QInserted true
/Contents 116 0 R
/Type /Page
/Resources <<
/ColorSpace <<
/CS1 [/Indexed /DeviceGray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
/CS2 [/Indexed /DeviceGray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
/CS0 [/Indexed /DeviceGray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
>>
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageI]
/Font <<
/T1_0 74 0 R
/TT3 99 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
/XObject <<
/Im1 117 0 R
/Im2 118 0 R
/Im0 119 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
26 0 obj
<<
/QInserted true
/Contents 120 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Font <<
/T1_0 74 0 R
/TT1 78 0 R
/TT0 76 0 R
>>
/XObject <<
/Im1 121 0 R
/Im2 122 0 R
/Im0 123 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
27 0 obj
<<
/QInserted true
/Contents 124 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 78 0 R
/TT1 125 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
28 0 obj
<<
/QInserted true
/Contents 126 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
29 0 obj
<<
/QInserted true
/Contents 127 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
30 0 obj
<<
/QInserted true
/Contents 128 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 86 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 6 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
31 0 obj
<<
/QInserted true
/Contents 129 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
32 0 obj
<<
/QInserted true
/Contents 130 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
33 0 obj
<<
/QInserted true
/Contents 131 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT4 132 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
34 0 obj
<<
/QInserted true
/Contents 133 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
35 0 obj
<<
/QInserted true
/Contents 134 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT4 135 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
36 0 obj
<<
/QInserted true
/Contents 136 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
37 0 obj
<<
/QInserted true
/Contents 137 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
38 0 obj
<<
/QInserted true
/Contents 138 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 78 0 R
/TT4 135 0 R
/TT1 86 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
39 0 obj
<<
/QInserted true
/Contents 139 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
40 0 obj
<<
/QInserted true
/Contents 140 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 7 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
41 0 obj
<<
/QInserted true
/Contents 141 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
42 0 obj
<<
/QInserted true
/Contents 142 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 78 0 R
/TT1 86 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
43 0 obj
<<
/QInserted true
/Contents 143 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
44 0 obj
<<
/QInserted true
/Contents 144 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
45 0 obj
<<
/QInserted true
/Contents 145 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 78 0 R
/TT1 86 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
46 0 obj
<<
/QInserted true
/Contents 146 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
47 0 obj
<<
/QInserted true
/Contents 147 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
48 0 obj
<<
/QInserted true
/Contents 148 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
49 0 obj
<<
/QInserted true
/Contents 149 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 75 0 R
/TT1 78 0 R
/TT2 86 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
50 0 obj
<<
/QInserted true
/Contents 150 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 8 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
51 0 obj
<<
/QInserted true
/Contents 151 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
52 0 obj
<<
/QInserted true
/Contents 152 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT3 86 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
53 0 obj
<<
/QInserted true
/Contents 153 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
54 0 obj
<<
/QInserted true
/Contents 154 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
55 0 obj
<<
/QInserted true
/Contents 155 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
56 0 obj
<<
/QInserted true
/Contents 156 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
57 0 obj
<<
/QInserted true
/Contents 157 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 75 0 R
/TT2 78 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
58 0 obj
<<
/QInserted true
/Contents 158 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/T1_0 74 0 R
/TT1 78 0 R
/TT2 75 0 R
/TT0 76 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
59 0 obj
<<
/QInserted true
/Contents 159 0 R
/Type /Page
/Resources <<
/ExtGState <<
/GS1 72 0 R
/GS0 73 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Font <<
/T1_0 74 0 R
/TT1 78 0 R
/TT0 76 0 R
>>
/XObject <<
/Im1 160 0 R
/Im2 161 0 R
/Im0 162 0 R
>>
>>
/CropBox [0 0 612 792]
/Parent 9 0 R
/Rotate 0
/MediaBox [0 0 612 792]
>>
endobj
60 0 obj
<<
/Length 2134
/Filter /FlateDecode
>>
stream
xXYoF&' dd2 -i3쑇n;~X"=$eC{weVW7l$GuW_ԧOD%
|ZVkC*i80>(YxG=IK3,
)d98=(嚢I-~8|;,WdK2ҵr$;nlmmuѝ9w2z|I?->RgiD,c[jMe2sKYKw-LG&γ-J3rEk`vgdแ)
k:PO&s&PO2fro
]ˤ9xnL_&W@p>`^ۏNg:gm+ddQ@mgC ܶVtMtԧԧ`EULۑi(vR0W`/Sk"DTܧ*eUcl4ݔwZmT5"=Qǧ/RW:HGj;l+2'xJv-ڲdBuehZ(('>C<}IR{nmX"3'[ܾ-FzRgxr"r"(ڡxylXrSrN01զ1(I2~t9
5iRڐɛ.%j b=zO=p%w[8[04Cb{dy;?0`GJI8H$@yS³|)> xO]v_U% \~G
צg$*yt 68sNf*dEpy4RYƥUҤAKS$uԑ@I4>>=a0%gcCi߸f&ԇ1k GqFϼ;4SX9'.ޢ|z(tJ06pHŅjz9=RNFup䐰UI(ža:b_&0s kI6@LXVGhVGWat|r#{ik\v#ly"4Ȕ7=]F!^4j=HIz
!L%0-@s:Zw@uk#dZAtnM<bjQ4+=8{/?6X"k/b}_:03G0Wmv{BEK3Q^mz!ZqEzh4=rabudz2?''#\/gBUxCm졀v00;9@, S
0pMB`x'C7L[gOCIμ52k^H>1^Q"sT*v@SI{iC!G,P"y\d
:r0C'dJ0pff8Kk
jr0