%PDF-1.4
%
1 0 obj
<<
/Metadata 2 0 R
/Names 3 0 R
/Outlines 4 0 R
/Pages 5 0 R
/Type /Catalog
/ViewerPreferences <<
/Direction /L2R
>>
>>
endobj
6 0 obj
<<
/CreationDate (D:20170923115014+01'00')
/Creator (Adobe InDesign CS6 \(Windows\))
/ModDate (D:20171219082010-08'00')
/Producer (Adobe PDF Library 10.0.1)
/Trapped /False
>>
endobj
2 0 obj
<<
/Length 2646
/Subtype /XML
/Type /Metadata
>>
stream
2017-09-23T11:50:14+01:00
2017-12-19T08:20:10-08:00
2017-12-19T08:20:10-08:00
Adobe InDesign CS6 (Windows)
uuid:a90874c1-1dd1-11b2-0a00-1e00286abfff
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
xmp.id:7213C7F74CA0E711BA579ACE63F6D91A
proof:pdf
xmp.iid:7113C7F74CA0E711BA579ACE63F6D91A
xmp.did:3B659C60092068118C14E71DDF3C18D1
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
default
converted
from application/x-indesign to application/pdf
Adobe InDesign CS6 (Windows)
/
2017-09-23T11:50:14+01:00
application/pdf
Adobe PDF Library 10.0.1
False
endstream
endobj
3 0 obj
<<
/Dests 7 0 R
>>
endobj
4 0 obj
<<
/Count 0
/Type /Outlines
>>
endobj
5 0 obj
<<
/Count 7
/Kids [8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R]
/Type /Pages
>>
endobj
7 0 obj
<<
/Names [(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:BLK_BX1:1983) [9 0 R /XYZ 387 548 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:BLK_T1:1980) [11 0 R /XYZ 48 743 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:BLK_T2:1981) [12 0 R /XYZ 149 63 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:BLK_T3:1982) [13 0 R /XYZ 48 743 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R10:1963) [13 0 R /XYZ 306 438 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R11:1964) [13 0 R /XYZ 306 421 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R12:1965) [13 0 R /XYZ 306 404 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R13:1966) [13 0 R /XYZ 306 379 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R14:1967) [13 0 R /XYZ 306 362 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R15:1968) [13 0 R /XYZ 306 328 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R16:1969) [13 0 R /XYZ 306 302 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R17:1970) [13 0 R /XYZ 306 277 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R18:1971) [13 0 R /XYZ 306 251 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R19:1972) [13 0 R /XYZ 306 234 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R1:1954) [13 0 R /XYZ 306 668 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R20:1973) [13 0 R /XYZ 306 217 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R21:1974) [13 0 R /XYZ 306 200 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R22:1975) [13 0 R /XYZ 306 183 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R23:1976) [13 0 R /XYZ 306 158 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R24:1977) [13 0 R /XYZ 306 132 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R25:1978) [13 0 R /XYZ 306 115 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R26:1979) [13 0 R /XYZ 306 90 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R2:1955) [13 0 R /XYZ 306 642 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R3:1956) [13 0 R /XYZ 306 617 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R4:1957) [13 0 R /XYZ 306 600 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R5:1958) [13 0 R /XYZ 306 574 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R6:1959) [13 0 R /XYZ 306 540 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R7:1960) [13 0 R /XYZ 306 515 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R8:1961) [13 0 R /XYZ 306 489 null]
(c486b962-e77e-4b7c-a901-35f514f3c9b1.indd:R9:1962) [13 0 R /XYZ 306 464 null]
]
>>
endobj
8 0 obj
<<
/Contents 15 0 R
/Type /Page
/Resources <<
/Font <<
/F1 16 0 R
/F2 17 0 R
/F3 18 0 R
/F4 19 0 R
>>
/XObject <<
/Xf1 20 0 R
>>
>>
/Annots [21 0 R 22 0 R 23 0 R]
/Parent 5 0 R
/MediaBox [0 0 595 842]
>>
endobj
9 0 obj
<<
/Annots [24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R
34 0 R 35 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 36 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ColorSpace <<
/CS0 [/Indexed /DeviceRGB 120 37 0 R]
/CS1 [/Indexed /DeviceRGB 117 38 0 R]
/CS2 [/Indexed /DeviceRGB 35 39 0 R]
/CS3 [/Indexed /DeviceRGB 56 40 0 R]
/CS4 [/Indexed /DeviceRGB 185 41 0 R]
/CS5 [/Indexed /DeviceRGB 59 42 0 R]
/CS6 [/Indexed /DeviceRGB 147 43 0 R]
/CS7 [/Indexed /DeviceRGB 19 44 0 R]
>>
/ExtGState <<
/GS0 45 0 R
/GS1 46 0 R
/GS2 47 0 R
>>
/Font <<
/C2_0 48 0 R
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 51 0 R
/T1_3 52 0 R
/T1_4 53 0 R
/T1_5 54 0 R
/T1_6 55 0 R
/T1_7 56 0 R
/TT0 57 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageI]
/Properties <<
/MC0 58 0 R
/MC1 59 0 R
/MC2 60 0 R
>>
/Shading <<
/Sh0 61 0 R
/Sh1 62 0 R
/Sh10 63 0 R
/Sh11 64 0 R
/Sh12 65 0 R
/Sh13 66 0 R
/Sh14 67 0 R
/Sh15 68 0 R
/Sh16 69 0 R
/Sh17 70 0 R
/Sh18 71 0 R
/Sh19 72 0 R
/Sh2 73 0 R
/Sh20 74 0 R
/Sh21 75 0 R
/Sh22 76 0 R
/Sh23 77 0 R
/Sh24 78 0 R
/Sh25 79 0 R
/Sh3 80 0 R
/Sh4 81 0 R
/Sh5 82 0 R
/Sh6 83 0 R
/Sh7 84 0 R
/Sh8 85 0 R
/Sh9 86 0 R
>>
/XObject <<
/Fm0 87 0 R
/Im0 88 0 R
/Im1 89 0 R
/Im10 90 0 R
/Im11 91 0 R
/Im12 92 0 R
/Im13 93 0 R
/Im14 94 0 R
/Im15 95 0 R
/Im16 96 0 R
/Im17 97 0 R
/Im18 98 0 R
/Im19 99 0 R
/Im2 100 0 R
/Im20 101 0 R
/Im21 102 0 R
/Im3 103 0 R
/Im4 104 0 R
/Im5 105 0 R
/Im6 106 0 R
/Im7 107 0 R
/Im8 108 0 R
/Im9 109 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
10 0 obj
<<
/Annots [110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R
120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R
130 0 R 131 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 132 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 45 0 R
/GS1 133 0 R
/GS2 134 0 R
>>
/Font <<
/C2_0 48 0 R
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 52 0 R
/T1_3 56 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 135 0 R
/Fm1 136 0 R
/Fm2 137 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
11 0 obj
<<
/Annots [138 0 R 139 0 R 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 147 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 45 0 R
/GS1 148 0 R
/GS2 149 0 R
/GS3 150 0 R
/GS4 151 0 R
>>
/Font <<
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 53 0 R
/T1_3 52 0 R
/T1_4 56 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 152 0 R
/Fm1 153 0 R
/Fm2 137 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
12 0 obj
<<
/Annots [154 0 R 155 0 R 156 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 157 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 45 0 R
/GS1 158 0 R
/GS2 159 0 R
/GS3 160 0 R
/GS4 161 0 R
>>
/Font <<
/C2_0 48 0 R
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 53 0 R
/T1_3 56 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 135 0 R
/Fm1 136 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
13 0 obj
<<
/Annots [162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R
172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R
182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 189 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 45 0 R
/GS1 190 0 R
/GS2 191 0 R
/GS3 192 0 R
/GS4 193 0 R
>>
/Font <<
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 53 0 R
/T1_3 52 0 R
/T1_4 51 0 R
/T1_5 194 0 R
/T1_6 56 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 195 0 R
/Fm1 196 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
14 0 obj
<<
/Annots [197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R]
/Contents 206 0 R
/MediaBox [0.0 0.0 595.0 793.0]
/Parent 5 0 R
/Resources <<
/Font <<
/T1_0 207 0 R
/T1_1 56 0 R
/T1_2 208 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/XObject <<
/Im0 209 0 R
>>
>>
/Type /Page
>>
endobj
15 0 obj
<<
/Length 1839
/Filter /FlateDecode
>>
stream
xX[sF2CZI۴̙6Hܝ\nl/2F
={v%.v!^\o|J1*̖;Tn =HJP-p<Nj=y8O#|k\,Ux5W|Wje;Wc˸XgiXWm#Kj)_B[,W}akz;4.t>YsXin{my,< C.Ob09^R3̈́\_~rnJQ䦂Rn?p20L[;-5K31t3p9':+UYzdRS=%UB9whtkO+彼RRjFט閫JI"=ttmԂC{-wXfm><7ɦİfņ 'm%P\Н]f4ӵڲ,\2glgXKXkJ:í}93?pB뛇q[OU1NF|M97JzcK4pgp[Ciml3nɸ??5Q3pkY@<,;ϲqC,땻m#k;WB-[ֶLp
uWלu@ae;kLSP<&jLsA-kŰ5ٔuYX؈^wلÙu Ǘ,[5m={ǧtsL5
Jiqk5leد Z =CO
g1w3?i" j oKt9J$Dr_q6 .=PM@y
)}Kw=B]v{P=xN~}M<>>mc~u8%j&S̘"(^n&t/WŔ]-7Csm23cS>@ਝSJM;23'_hoqɔve2:]8qH&qj!6YOW>=4vb(*cѿH,HtmtG-J~JI7@r~S--z2ٖ$"on]YiOdD:6Ѱ$%F-<ĩV#G4Ɛ Se 3 xx
^(퀸ZWԞMMa^L`6l|NA》2) w1# cR6OrR%'PxOIӚRFLH]Ovp
ܥ۲ dz$+=: ElKGfxv^E+.!gLԇLwp
:8ˈ= @IǷ.XtJ#&l{1Ieٰ/b]zRS
DT;bGi,[_!R1Dͮ6,ྲ9%IS4dDb>ĭ Fg|"O*ʦ
Ÿ?
b|FJTj/1nVѷ!YC+ws
~#{oKo}@)X8"3aӗumDVyJ+EPzL[Z{E-t
endstream
endobj
16 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
17 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
18 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
19 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /YVRKNB+LiberationSans
/Encoding /Identity-H
/DescendantFonts [210 0 R]
/ToUnicode 211 0 R
>>
endobj
20 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 212 0 R
>>
/Font <<
/F1 213 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
21 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1136/bmjopen-2016-015242)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 576 196.53 586]
>>
endobj
22 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1136/bmjopen-2016-015242)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 461 259.9 471]
>>
endobj
23 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/ebe84689-2e73-466d-997c-69c3387ff18a)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 391 291.54 401]
>>
endobj
24 0 obj
<<
/A 214 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [38.5 34.7508 63.8448 18.2302]
/Subtype /Link
/Type /Annot
>>
endobj
25 0 obj
<<
/A 215 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [432.46 375.443 435.908 363.663]
/Subtype /Link
/Type /Annot
>>
endobj
26 0 obj
<<
/A 216 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [395.145 303.443 398.592 291.663]
/Subtype /Link
/Type /Annot
>>
endobj
27 0 obj
<<
/A 217 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [551.323 207.443 554.771 195.663]
/Subtype /Link
/Type /Annot
>>
endobj
28 0 obj
<<
/A 218 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [452.653 135.443 456.1 123.663]
/Subtype /Link
/Type /Annot
>>
endobj
29 0 obj
<<
/A 219 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [448.671 111.443 452.118 99.663]
/Subtype /Link
/Type /Annot
>>
endobj
30 0 obj
<<
/A 220 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [95.4347 459.079 133.034 449.927]
/Subtype /Link
/Type /Annot
>>
endobj
31 0 obj
<<
/A 221 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [40.5 449.079 126.147 439.927]
/Subtype /Link
/Type /Annot
>>
endobj
32 0 obj
<<
/A 222 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [40.5 439.079 63.5398 429.927]
/Subtype /Link
/Type /Annot
>>
endobj
33 0 obj
<<
/A 223 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [38.5 177.439 139.284 134.137]
/Subtype /Link
/Type /Annot
>>
endobj
34 0 obj
<<
/A 224 0 R
/Border [0 0 0]
/Rect [190.452 778.0 277.82 788.0]
/Subtype /Link
/Type /Annot
>>
endobj
35 0 obj
<<
/A 225 0 R
/Border [0 0 0]
/Rect [414.556 778.0 469.46 788.0]
/Subtype /Link
/Type /Annot
>>
endobj
36 0 obj
<<
/Length 34408
/Filter /FlateDecode
>>
stream
HWn
+%LS*a`vIb﮿ͻ|Eѻ6`G?H?<"IL$~7}ʿ{o[
agIeW>z0v&`:Gou^!OUn
~Lp_!QYqkEd+@ A"p
?(x:x;=S?EA
s&%,%ڃ3ᇡ$ NqNs³\Al8Q%Θ9J0.0$"g@ϊ"IRDqr