%PDF-1.6
%
1 0 obj
<<
/PageMode /UseNone
/Names 2 0 R
/Outlines 3 0 R
/Metadata 4 0 R
/JT 5 0 R
/Pages 6 0 R
/PageLayout /Continuous
/OpenAction [7 0 R /FitH 810]
/Threads [8 0 R]
/Type /Catalog
/PageLabels 9 0 R
>>
endobj
10 0 obj
<<
/CrossmarkMajorVersionDate (2017-05-30)
/CreationDate (D:20170530163511+05'30')
/Subject (Chemical Science \(2017\), 8, 4644-4653, doi:10.1039/C6SC05044A)
/Author (Tom Podewin)
/Creator (Arbortext Advanced Print Publisher 9.1.510/W Unicode)
/Producer <4163726F6261742044697374696C6C657220382E312E30202857696E646F7773293B206D6F646966696564207573696E67206954657874AE20352E332E3320A9323030302D32303132203154335854204256424120284147504C2D76657273696F6E29>
/CrossmarkDomainExclusive (false)
/ModDate (D:20171102165443+00'00')
/doi (10.1039/C6SC05044A)
/CrossMarkDomains#5B1#5D (rsc.org)
/Title (Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone)
>>
endobj
2 0 obj
<<
/Dests 11 0 R
>>
endobj
3 0 obj
<<
/First 12 0 R
/Count 1
/Last 12 0 R
>>
endobj
4 0 obj
<<
/Length 6735
/Type /Metadata
/Subtype /XML
>>
stream
application/pdf
doi:10.1039/C6SC05044A
Tom Podewin
Johannes Broichhagen
Christina Frost
Dieter Groneberg
Julia Ast
Helena Meyer-Berg
Nicholas H. F. Fine
Andreas Friebe
Martin Zacharias
David J. Hodson
Dirk Trauner
Anja Hoffmann-Röder
Chemical Science (2017), 8, 4644-4653, doi:10.1039/C6SC05044A
Royal Society of Chemistry
This journal is © The Royal Society of Chemistry 2014
Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone
This journal is © The Royal Society of Chemistry 2014
10.1039/C6SC05044A
2041-6539
4653
2041-6520
Chemical Science
4644
8
2017-05-30
http://dx.doi.org/10.1039/C6SC05044A
2017-05-30
false
10.1039/C6SC05044A
rsc.org
10.1039/C6SC05044A
2017-05-30
false
rsc.org
2017-05-30T16:35:11+05:30
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2017-11-02T16:54:43+00:00
2017-11-02T16:54:43+00:00
Acrobat Distiller 8.1.0 (Windows); modified using iText® 5.3.3 ©2000-2012 1T3XT BVBA (AGPL-version)
uuid:64207bd9-b5b4-4522-a069-3126fac9f899
uuid:8e29a931-703e-4375-b4ff-8299bcd16186
endstream
endobj
5 0 obj
<<
/A [13 0 R]
/V 1.1
/Cn [14 0 R]
>>
endobj
6 0 obj
<<
/Count 11
/Type /Pages
/Kids [15 0 R 7 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R
24 0 R]
>>
endobj
7 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Annots [25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R
35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R]
/Parent 6 0 R
/B [43 0 R 44 0 R 45 0 R 46 0 R]
/Contents [47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/XObject <<
/Im1 57 0 R
/Im2 58 0 R
/Xi0 59 0 R
/Xi1 60 0 R
/Xi2 61 0 R
/Xi3 62 0 R
/Xi4 63 0 R
/Xi5 64 0 R
/Xi6 65 0 R
>>
/Shading <<
/Sh1 66 0 R
>>
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
/Cs8 [/Separation /C5_M5_Y15_K8 [/ICCBased 67 0 R]
68 0 R]
/Cs9 [/Separation /C68_M35Y_17K_40 [/ICCBased 67 0 R]
69 0 R]
>>
/Font <<
/F12 70 0 R
/F13 71 0 R
/F14 72 0 R
/F15 73 0 R
/F16 74 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F1 78 0 R
/F2 79 0 R
/F3 80 0 R
/F4 81 0 R
/F5 82 0 R
/F6 83 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/Properties <<
/MC10 89 0 R
/MC11 90 0 R
/MC12 91 0 R
/MC13 92 0 R
/MC14 93 0 R
/MC1 94 0 R
/MC2 95 0 R
/MC3 96 0 R
/MC4 97 0 R
/MC5 98 0 R
/MC6 99 0 R
/MC7 100 0 R
/MC8 101 0 R
/MC9 102 0 R
>>
/ExtGState <<
/GS1 103 0 R
/GS2 104 0 R
>>
>>
/Type /Page
>>
endobj
8 0 obj
<<
/F 43 0 R
/I 105 0 R
>>
endobj
9 0 obj
<<
/Nums [0 106 0 R]
>>
endobj
11 0 obj
<<
/Kids [107 0 R 108 0 R]
>>
endobj
12 0 obj
<<
/First 109 0 R
/Parent 3 0 R
/Dest
/Count -4
/Last 110 0 R
/Title
>>
endobj
13 0 obj
<<
/JTM (Distiller)
/Dt (D:20170530163516)
>>
endobj
14 0 obj
<<
/D [111 0 R]
/Type /JobTicketContents
/MS 112 0 R
>>
endobj
15 0 obj
<<
/Contents 113 0 R
/Type /Page
/Resources <<
/Font <<
/F1 114 0 R
/F2 115 0 R
/F3 116 0 R
/F4 117 0 R
>>
/XObject <<
/Xf1 118 0 R
>>
>>
/Annots [119 0 R 120 0 R 121 0 R]
/Parent 6 0 R
/MediaBox [0 0 595 842]
>>
endobj
16 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [122 0 R 123 0 R]
/Contents [124 0 R 125 0 R 126 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/XObject <<
/Im3 127 0 R
/Xi7 59 0 R
/Xi8 60 0 R
/Xi9 61 0 R
/Xi10 62 0 R
/Xi11 128 0 R
>>
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
/Cs8 [/Separation /C5_M5_Y15_K8 [/ICCBased 67 0 R]
68 0 R]
>>
/Font <<
/F13 71 0 R
/F14 72 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F1 78 0 R
/F3 80 0 R
/F4 81 0 R
/F6 83 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
>>
/Type /Page
/Annots [129 0 R 130 0 R 131 0 R]
>>
endobj
17 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [132 0 R 133 0 R 134 0 R]
/Contents [135 0 R 136 0 R 137 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/XObject <<
/Im4 138 0 R
/Xi12 59 0 R
/Xi13 60 0 R
/Xi14 61 0 R
/Xi15 62 0 R
/Xi16 128 0 R
>>
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
/Cs8 [/Separation /C5_M5_Y15_K8 [/ICCBased 67 0 R]
68 0 R]
>>
/Font <<
/F12 70 0 R
/F13 71 0 R
/F16 74 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F20 139 0 R
/F21 140 0 R
/F22 141 0 R
/F23 142 0 R
/F24 143 0 R
/F1 78 0 R
/F3 80 0 R
/F4 81 0 R
/F6 83 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
>>
/Type /Page
/Annots [144 0 R 145 0 R 146 0 R]
>>
endobj
18 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [147 0 R 148 0 R]
/Contents [149 0 R 150 0 R 151 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/XObject <<
/Im5 152 0 R
/Xi17 59 0 R
/Xi18 60 0 R
/Xi19 61 0 R
/Xi20 62 0 R
/Xi21 128 0 R
>>
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
/Cs8 [/Separation /C5_M5_Y15_K8 [/ICCBased 67 0 R]
68 0 R]
>>
/Font <<
/F12 70 0 R
/F13 71 0 R
/F14 72 0 R
/F16 74 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F20 139 0 R
/F21 140 0 R
/F22 141 0 R
/F23 142 0 R
/F25 153 0 R
/F1 78 0 R
/F3 80 0 R
/F4 81 0 R
/F6 83 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
>>
/Type /Page
/Annots [154 0 R 155 0 R 156 0 R]
>>
endobj
19 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [157 0 R 158 0 R 159 0 R]
/Contents [160 0 R 161 0 R 162 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/XObject <<
/Im6 163 0 R
/Xi22 59 0 R
/Xi23 60 0 R
/Xi24 61 0 R
/Xi25 62 0 R
/Xi26 128 0 R
>>
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
/Cs8 [/Separation /C5_M5_Y15_K8 [/ICCBased 67 0 R]
68 0 R]
>>
/Font <<
/F12 70 0 R
/F13 71 0 R
/F16 74 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F21 140 0 R
/F22 141 0 R
/F23 142 0 R
/F24 143 0 R
/F26 164 0 R
/F27 165 0 R
/F1 78 0 R
/F3 80 0 R
/F4 81 0 R
/F5 82 0 R
/F6 83 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
>>
/Type /Page
/Annots [166 0 R 167 0 R 168 0 R]
>>
endobj
20 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [169 0 R 170 0 R]
/Contents [171 0 R 172 0 R 173 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/XObject <<
/Im7 174 0 R
/Xi27 59 0 R
/Xi28 60 0 R
/Xi29 61 0 R
/Xi30 62 0 R
/Xi31 128 0 R
>>
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
/Cs8 [/Separation /C5_M5_Y15_K8 [/ICCBased 67 0 R]
68 0 R]
>>
/Font <<
/F12 70 0 R
/F13 71 0 R
/F16 74 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F20 139 0 R
/F23 142 0 R
/F27 165 0 R
/F28 175 0 R
/F29 176 0 R
/F1 78 0 R
/F3 80 0 R
/F4 81 0 R
/F5 82 0 R
/F6 83 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
>>
/Type /Page
/Annots [177 0 R 178 0 R 179 0 R]
>>
endobj
21 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [180 0 R 181 0 R 182 0 R]
/Contents [183 0 R 184 0 R 185 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
>>
/Font <<
/F13 71 0 R
/F16 74 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F20 139 0 R
/F1 78 0 R
/F4 81 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
/XObject <<
/Xi32 59 0 R
/Xi33 60 0 R
/Xi34 61 0 R
/Xi35 62 0 R
/Xi36 128 0 R
>>
>>
/Type /Page
/Annots [186 0 R 187 0 R 188 0 R]
>>
endobj
22 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [189 0 R 190 0 R 191 0 R]
/Contents [192 0 R 193 0 R 194 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
>>
/Font <<
/F12 70 0 R
/F13 71 0 R
/F16 74 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F20 139 0 R
/F23 142 0 R
/F1 78 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
/XObject <<
/Xi37 59 0 R
/Xi38 60 0 R
/Xi39 61 0 R
/Xi40 62 0 R
/Xi41 128 0 R
>>
>>
/Type /Page
/Annots [195 0 R 196 0 R 197 0 R]
>>
endobj
23 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [198 0 R 199 0 R]
/Contents [200 0 R 201 0 R 202 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
>>
/Font <<
/F12 70 0 R
/F13 71 0 R
/F16 74 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F1 78 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
/F11 88 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
/XObject <<
/Xi42 59 0 R
/Xi43 60 0 R
/Xi44 61 0 R
/Xi45 62 0 R
/Xi46 128 0 R
>>
>>
/Type /Page
/Annots [203 0 R 204 0 R 205 0 R]
>>
endobj
24 0 obj
<<
/CropBox [0 0 595.276 779.528]
/Parent 6 0 R
/B [206 0 R 207 0 R]
/Contents [208 0 R 209 0 R 210 0 R]
/Rotate 0
/MediaBox [0 0 595.276 779.528]
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 67 0 R]
>>
/Font <<
/F12 70 0 R
/F13 71 0 R
/F17 75 0 R
/F18 76 0 R
/F19 77 0 R
/F20 139 0 R
/F30 211 0 R
/F1 78 0 R
/F7 84 0 R
/F8 85 0 R
/F9 86 0 R
/F10 87 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS1 103 0 R
>>
/XObject <<
/Xi47 59 0 R
/Xi48 60 0 R
/Xi49 61 0 R
/Xi50 62 0 R
/Xi51 128 0 R
>>
>>
/Type /Page
/Annots [212 0 R 213 0 R 214 0 R]
>>
endobj
25 0 obj
<<
/Rect [42.52 625.153 140.258 643.861]
/Subtype /Widget
/TU (Click for updates and to verify authenticity)
/A 215 0 R
/F 4
/T (Click for updates and to verify authenticity)
/FT /Btn
/Type /Annot
/Ff 65536
>>
endobj
26 0 obj
<<
/Rect [238.79 573.165 250.413 583.37]
/Subtype /Link
/A 216 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
27 0 obj
<<
/Rect [374.23 573.165 385.852 583.37]
/Subtype /Link
/A 217 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
28 0 obj
<<
/Rect [470.664 573.165 482.286 583.37]
/Subtype /Link
/A 218 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
29 0 obj
<<
/Rect [254.324 561.203 265.946 571.408]
/Subtype /Link
/A 219 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
30 0 obj
<<
/Rect [313.172 561.203 324.794 571.408]
/Subtype /Link
/A 220 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
31 0 obj
<<
/Rect [427.408 561.203 439.03 571.408]
/Subtype /Link
/A 221 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
32 0 obj
<<
/Rect [531.212 561.203 542.834 571.408]
/Subtype /Link
/A 222 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
33 0 obj
<<
/Rect [242.419 549.241 254.041 559.445]
/Subtype /Link
/A 223 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
34 0 obj
<<
/Rect [339.194 549.241 350.816 559.445]
/Subtype /Link
/A 224 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
35 0 obj
<<
/Rect [436.989 549.241 448.611 559.445]
/Subtype /Link
/A 225 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
36 0 obj
<<
/Rect [518.06 549.241 529.682 559.445]
/Subtype /Link
/A 226 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
37 0 obj
<<
/Rect [293.046 537.279 304.668 547.483]
/Subtype /Link
/A 227 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
38 0 obj
<<
/Subtype /Link
/Rect [14 289.76 26 353.76]
/A <<
/S /URI
/URI (http://creativecommons.org/licenses/by/3.0/)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
39 0 obj
<<
/Subtype /Link
/Rect [14 458.49 24 631.59]
/A <<
/S /URI
/URI (http://creativecommons.org/licenses/by/3.0/)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
40 0 obj
<<
/Subtype /Link
/Rect [452.41 676.53 535.28 687.53]
/A <<
/S /URI
/URI (http://dx.doi.org/10.1039/c6sc05044a)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
41 0 obj
<<
/Subtype /Link
/Rect [452.7 666.53 489.78 674.53]
/A <<
/S /URI
/URI (http://pubs.rsc.org/en/journals/journal/SC)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
42 0 obj
<<
/Subtype /Link
/Rect [490.7 666.53 525.78 674.53]
/A <<
/S /URI
/URI (http://pubs.rsc.org/en/journals/journal/SC?issueid=SC008006)
>>
/Border [0 0 0]
/C [0 0 1]
>>
endobj
43 0 obj
<<
/N 44 0 R
/P 7 0 R
/R [40 622 295 647]
/T 8 0 R
/V 207 0 R
>>
endobj
44 0 obj
<<
/N 45 0 R
/P 7 0 R
/R [170 343 556 649]
/T 8 0 R
/V 43 0 R
>>
endobj
45 0 obj
<<
/N 46 0 R
/P 7 0 R
/R [40 264 295 330]
/T 8 0 R
/V 44 0 R
>>
endobj
46 0 obj
<<
/N 122 0 R
/P 7 0 R
/R [300 50 556 330]
/T 8 0 R
/V 45 0 R
>>
endobj
47 0 obj
<<
/Length 10
/Filter /FlateDecode
>>
stream
x+ |
endstream
endobj
48 0 obj
<<
/Length 2230
/Filter /FlateDecode
>>
stream
HlWˎ%I
߯~lie9*ÙDZ?}~|~xXS9Zg~<{x?J:ۨOǯ7eL^oz;YΡ|9<Mjg,&7l$qzBg)K~|z:7(<ͧ/o@8 vnjg x}%o_n?`ji#)"=LFDq֘w|~#6q41?K8J<"4~{WM42Dm
ywao1q Z`^?o -s~ْyܖ,/Dm%v#ʂviPc{=
;Jj`JwbrzYz g/U!dFi0NRЈ0J#3iGX'N=BbtRN|
'^3kSJCA 9XF*``VV7 f