%PDF-1.4
%
1 0 obj
<<
/Metadata 2 0 R
/Names 3 0 R
/Outlines 4 0 R
/Pages 5 0 R
/Type /Catalog
/ViewerPreferences <<
/Direction /L2R
>>
>>
endobj
6 0 obj
<<
/CreationDate (D:20170710080222+01'00')
/Creator (Adobe InDesign CS6 \(Windows\))
/ModDate (D:20170727023011-07'00')
/Producer (Adobe PDF Library 10.0.1)
/Trapped /False
>>
endobj
2 0 obj
<<
/Length 2646
/Subtype /XML
/Type /Metadata
>>
stream
2017-07-10T08:02:22+01:00
2017-07-27T02:30:11-07:00
2017-07-27T02:30:11-07:00
Adobe InDesign CS6 (Windows)
uuid:65b6459d-1dd2-11b2-0a00-c900381a8aff
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
xmp.id:0C2222B83D65E711AABDD7017EE9AE47
proof:pdf
xmp.iid:0B2222B83D65E711AABDD7017EE9AE47
xmp.did:3B659C60092068118C14E71DDF3C18D1
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
default
converted
from application/x-indesign to application/pdf
Adobe InDesign CS6 (Windows)
/
2017-07-10T08:02:22+01:00
application/pdf
Adobe PDF Library 10.0.1
False
endstream
endobj
3 0 obj
<<
/Dests 7 0 R
>>
endobj
4 0 obj
<<
/Count 0
/Type /Outlines
>>
endobj
5 0 obj
<<
/Count 7
/Kids [8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R]
/Type /Pages
>>
endobj
7 0 obj
<<
/Names [(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:BLK_BX1:1977) [9 0 R /XYZ 387 523 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:BLK_T1:1976) [11 0 R /XYZ 48 743 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R10:1963) [13 0 R /XYZ 40 621 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R11:1964) [13 0 R /XYZ 40 595 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R12:1965) [13 0 R /XYZ 40 570 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R13:1966) [13 0 R /XYZ 40 544 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R14:1967) [13 0 R /XYZ 306 748 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R15:1968) [13 0 R /XYZ 306 723 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R16:1969) [13 0 R /XYZ 306 689 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R17:1970) [13 0 R /XYZ 306 655 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R18:1971) [13 0 R /XYZ 306 638 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R19:1972) [13 0 R /XYZ 306 612 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R1:1954) [12 0 R /XYZ 306 122 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R20:1973) [13 0 R /XYZ 306 578 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R21:1974) [13 0 R /XYZ 306 561 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R22:1975) [13 0 R /XYZ 306 536 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R2:1955) [12 0 R /XYZ 306 105 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R3:1956) [12 0 R /XYZ 306 71 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R4:1957) [13 0 R /XYZ 40 748 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R5:1958) [13 0 R /XYZ 40 723 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R6:1959) [13 0 R /XYZ 40 706 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R7:1960) [13 0 R /XYZ 40 689 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R8:1961) [13 0 R /XYZ 40 655 null]
(e1f81e42-a4e5-4beb-a71c-3d013a6b88e1.indd:R9:1962) [13 0 R /XYZ 40 638 null]
]
>>
endobj
8 0 obj
<<
/Contents 15 0 R
/Type /Page
/Resources <<
/Font <<
/F1 16 0 R
/F2 17 0 R
/F3 18 0 R
/F4 19 0 R
>>
/XObject <<
/Xf1 20 0 R
>>
>>
/Annots [21 0 R 22 0 R 23 0 R]
/Parent 5 0 R
/MediaBox [0 0 595 842]
>>
endobj
9 0 obj
<<
/Annots [24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R
34 0 R 35 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 36 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ColorSpace <<
/CS0 [/Indexed /DeviceRGB 120 37 0 R]
/CS1 [/Indexed /DeviceRGB 117 38 0 R]
/CS2 [/Indexed /DeviceRGB 35 39 0 R]
/CS3 [/Indexed /DeviceRGB 56 40 0 R]
/CS4 [/Indexed /DeviceRGB 185 41 0 R]
/CS5 [/Indexed /DeviceRGB 59 42 0 R]
/CS6 [/Indexed /DeviceRGB 147 43 0 R]
/CS7 [/Indexed /DeviceRGB 19 44 0 R]
>>
/ExtGState <<
/GS0 45 0 R
/GS1 46 0 R
/GS2 47 0 R
>>
/Font <<
/C2_0 48 0 R
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 51 0 R
/T1_3 52 0 R
/T1_4 53 0 R
/T1_5 54 0 R
/T1_6 55 0 R
/T1_7 56 0 R
/T1_8 57 0 R
/TT0 58 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageI]
/Properties <<
/MC0 59 0 R
/MC1 60 0 R
/MC2 61 0 R
>>
/Shading <<
/Sh0 62 0 R
/Sh1 63 0 R
/Sh10 64 0 R
/Sh11 65 0 R
/Sh12 66 0 R
/Sh13 67 0 R
/Sh14 68 0 R
/Sh15 69 0 R
/Sh16 70 0 R
/Sh17 71 0 R
/Sh18 72 0 R
/Sh19 73 0 R
/Sh2 74 0 R
/Sh20 75 0 R
/Sh21 76 0 R
/Sh22 77 0 R
/Sh23 78 0 R
/Sh24 79 0 R
/Sh25 80 0 R
/Sh3 81 0 R
/Sh4 82 0 R
/Sh5 83 0 R
/Sh6 84 0 R
/Sh7 85 0 R
/Sh8 86 0 R
/Sh9 87 0 R
>>
/XObject <<
/Fm0 88 0 R
/Im0 89 0 R
/Im1 90 0 R
/Im10 91 0 R
/Im11 92 0 R
/Im12 93 0 R
/Im13 94 0 R
/Im14 95 0 R
/Im15 96 0 R
/Im16 97 0 R
/Im17 98 0 R
/Im18 99 0 R
/Im19 100 0 R
/Im2 101 0 R
/Im20 102 0 R
/Im21 103 0 R
/Im3 104 0 R
/Im4 105 0 R
/Im5 106 0 R
/Im6 107 0 R
/Im7 108 0 R
/Im8 109 0 R
/Im9 110 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
10 0 obj
<<
/Annots [111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R 120 0 R
121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 127 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 45 0 R
/GS1 128 0 R
/GS2 129 0 R
>>
/Font <<
/C2_0 48 0 R
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 54 0 R
/T1_3 53 0 R
/T1_4 57 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 130 0 R
/Fm1 131 0 R
/Fm2 132 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
11 0 obj
<<
/Annots [133 0 R 134 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 135 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 45 0 R
/GS1 136 0 R
/GS2 137 0 R
/GS3 138 0 R
/GS4 139 0 R
>>
/Font <<
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 55 0 R
/T1_3 54 0 R
/T1_4 53 0 R
/T1_5 52 0 R
/T1_6 57 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 140 0 R
/Fm1 141 0 R
/Fm2 132 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
12 0 obj
<<
/Annots [142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R
152 0 R 153 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 154 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 45 0 R
/GS1 155 0 R
/GS2 156 0 R
>>
/Font <<
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 53 0 R
/T1_3 54 0 R
/T1_4 52 0 R
/T1_5 51 0 R
/T1_6 55 0 R
/T1_7 157 0 R
/T1_8 57 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 130 0 R
/Fm1 131 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
13 0 obj
<<
/Annots [158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R
168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 178 0 R
/CropBox [0.0 0.0 595.276 793.701]
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/Resources <<
/ExtGState <<
/GS0 45 0 R
/GS1 179 0 R
/GS2 180 0 R
>>
/Font <<
/T1_0 49 0 R
/T1_1 50 0 R
/T1_2 55 0 R
/T1_3 157 0 R
/T1_4 57 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 181 0 R
/Fm1 182 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
14 0 obj
<<
/Annots [183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R]
/Contents 192 0 R
/MediaBox [0.0 0.0 595.0 793.0]
/Parent 5 0 R
/Resources <<
/Font <<
/T1_0 193 0 R
/T1_1 57 0 R
/T1_2 194 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/XObject <<
/Im0 195 0 R
>>
>>
/Type /Page
>>
endobj
15 0 obj
<<
/Length 1782
/Filter /FlateDecode
>>
stream
xW[sF;}kδM`~-vIE(-IoгgWtv0;.A
~Z*
f+8WAg`es9wg5]ǩ` MaG~w_݀z:q/VVo.#ިеz݂[}˝ڳm|4 t{܃l`>efufZ^8',/谭vlX{BlzapsvrUoD4P5Jx'Z12e^ NdoZl>Ė{߸Uu|jؼo
a
jen?wSiZ)jqxzֶ{U~WS;3ORUӮ-tV+ds圂קpr}&f&9Qk7-70;%\k 6~:7Zãľ}ݳG˛߾p i)"h)"f)"%!$pN`?}diNFx\2>K؟p6ٌ-ӡ *ۋ j xE0-ˀtE!כ9s{8/ZmfpA~ oholk>`v=:sSڮ!<5*%b*S&)(:~
tpĤk2§>㷧ti2T[z2SPB]Һo#8u#66;c'oLNqHfL~
(hsk,ge5w{(;k \p)?p8( ^ +\>0{p\FD["2%ؾ,Pz$F'":$IVv"iQS7^&LB֎I>sAcRgČ^ -Oö)қ!v%ytJ_!/Zg
Ey>Nj!uS,Q<1Ą,Odj600DiMNK{Ԟ-aQ#F3lϵ hVZ5#&L;JĀcLHήisN`姤i)锦LH!;u]Y2=:ՠ@l%ŋ'3Ԍ UZ^S&ȂR``~
Oʏ3ufGl4'HmV.S<(E_>EIHl\HYdFDDw+G2ޓ{}DIڄG2XxRv,RjDG %6QtfHS]|ɝDΤ@D\v=YH+߄FxZ"uQJ٥9Ɵѳ/b{:Qf( q@NxT
،P!X[f,v0qG8q"t,n"ҪP&8,J$OXQ#b(Oc@#FYI10JtJi.ՔU5d~В1'y$PJTo{IaQ%Bq7zݯ~1gKt/t=$ܣ{Nn\B_nM=T NxƂe.u*RpCdr
^^)bR.h:*Ys/#WWƓV@
endstream
endobj
16 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
17 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
18 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
19 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /WRQWOI+LiberationSans
/Encoding /Identity-H
/DescendantFonts [196 0 R]
/ToUnicode 197 0 R
>>
endobj
20 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 198 0 R
>>
/Font <<
/F1 199 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
21 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1136/bmjopen-2017-017291)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 556 196.53 566]
>>
endobj
22 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1136/bmjopen-2017-017291)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [186.54 441 389.44 451]
>>
endobj
23 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/5b90606a-1696-49de-9c6b-dd9035979d37)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 371 291.54 381]
>>
endobj
24 0 obj
<<
/A 200 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [38.5 34.7508 63.8448 18.2302]
/Subtype /Link
/Type /Annot
>>
endobj
25 0 obj
<<
/A 201 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [219.445 75.4672 222.893 63.6871]
/Subtype /Link
/Type /Annot
>>
endobj
26 0 obj
<<
/A 202 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [463.652 268.249 467.1 256.469]
/Subtype /Link
/Type /Annot
>>
endobj
27 0 obj
<<
/A 203 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [508.009 196.069 511.456 184.289]
/Subtype /Link
/Type /Annot
>>
endobj
28 0 obj
<<
/A 204 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [526.888 147.949 530.335 136.169]
/Subtype /Link
/Type /Annot
>>
endobj
29 0 obj
<<
/A 205 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [550.942 87.7986 554.39 76.0185]
/Subtype /Link
/Type /Annot
>>
endobj
30 0 obj
<<
/A 206 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [95.4347 423.925 133.034 414.773]
/Subtype /Link
/Type /Annot
>>
endobj
31 0 obj
<<
/A 207 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [40.5 413.925 126.147 404.773]
/Subtype /Link
/Type /Annot
>>
endobj
32 0 obj
<<
/A 208 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [40.5 403.925 63.5398 394.773]
/Subtype /Link
/Type /Annot
>>
endobj
33 0 obj
<<
/A 209 0 R
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/H /N
/Rect [38.5 227.439 139.284 184.137]
/Subtype /Link
/Type /Annot
>>
endobj
34 0 obj
<<
/A 210 0 R
/Border [0 0 0]
/Rect [201.788 778.0 289.156 788.0]
/Subtype /Link
/Type /Annot
>>
endobj
35 0 obj
<<
/A 211 0 R
/Border [0 0 0]
/Rect [403.22 778.0 458.124 788.0]
/Subtype /Link
/Type /Annot
>>
endobj
36 0 obj
<<
/Length 34961
/Filter /FlateDecode
>>
stream
HW]oܸ-TWq\dd,t7[鮧CSQ&&|sIgc?#yy~j\싖r<J?ß.~DP