%PDF-1.7
%
1 0 obj
<<
/PageMode /UseThumbs
/Metadata 2 0 R
/Pages 3 0 R
/PageLayout /SinglePage
/OpenAction 4 0 R
/Type /Catalog
>>
endobj
5 0 obj
<<
/CreationDate (D:20150930110319Z)
/Subject (Progress in Cardiovascular Diseases, Accepted manuscript. doi:10.1016/j.pcad.2015.09.005)
/Author (Eduard Shantsila)
/Creator (Elsevier)
/Keywords (AF; Atrial fibrillation; CAD; Coronary artery disease; HF; Heart failure; HFrEF; Heart failure with reduced ejection fraction; LA; Left atrium or atrial; LAA; Left atrial appendage; LV; Left ventricle or ventricular; LVEF; Left ventricular ejection fraction; NSR; Normal sinus rhythm; NYHA; New York Heart Association; NVAF; Non-valvular atrial fibrillation; SCD; Sudden cardiac death; VTE; Venous thromboembolism; heart failure; thrombosis; oral anticoagulants; atrial fibrillation)
/Producer (Acrobat Distiller 4.05 for Windows)
/ElsevierWebPDFSpecifications (6.4)
/ModDate (D:20150930182017+08'00')
/doi (10.1016/j.pcad.2015.09.005)
/Title (Preventing Thrombosis to Improve Outcomes in Heart Failure Patients)
>>
endobj
2 0 obj
<<
/Length 7250
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
doi:10.1016/j.pcad.2015.09.005
Preventing Thrombosis to Improve Outcomes in Heart Failure Patients
Eduard Shantsila
Gregory Y.H. Lip
AF
Atrial fibrillation
CAD
Coronary artery disease
HF
Heart failure
HFrEF
Heart failure with reduced ejection fraction
LA
Left atrium or atrial
LAA
Left atrial appendage
LV
Left ventricle or ventricular
LVEF
Left ventricular ejection fraction
NSR
Normal sinus rhythm
NYHA
New York Heart Association
NVAF
Non-valvular atrial fibrillation
SCD
Sudden cardiac death
VTE
Venous thromboembolism
heart failure
thrombosis
oral anticoagulants
atrial fibrillation
Progress in Cardiovascular Diseases, Accepted manuscript. doi:10.1016/j.pcad.2015.09.005
Elsevier B.V.
journal
Progress in Cardiovascular Diseases
Copyright (c) 2015 Elsevier B.V. All rights reserved
0033-0620
10.1016/j.pcad.2015.09.005
http://dx.doi.org/10.1016/j.pcad.2015.09.005
6.4
10.1016/j.pcad.2015.09.005
Elsevier
2015-09-30T11:03:19Z
2015-09-30T18:20:17+08:00
2015-09-30T18:20:17+08:00
True
AF; Atrial fibrillation; CAD; Coronary artery disease; HF; Heart failure; HFrEF; Heart failure with reduced ejection fraction; LA; Left atrium or atrial; LAA; Left atrial appendage; LV; Left ventricle or ventricular; LVEF; Left ventricular ejection fraction; NSR; Normal sinus rhythm; NYHA; New York Heart Association; NVAF; Non-valvular atrial fibrillation; SCD; Sudden cardiac death; VTE; Venous thromboembolism; heart failure; thrombosis; oral anticoagulants; atrial fibrillation
Acrobat Distiller 4.05 for Windows
uuid:5009f03f-c1e7-4685-a7fb-2cee4a605267
uuid:538a887a-8fdc-48af-a90e-855163100516
endstream
endobj
3 0 obj
<<
/Count 26
/Type /Pages
/Kids [6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R
16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R
26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R]
>>
endobj
4 0 obj
<<
/D [7 0 R /FitH -32768]
/S /GoTo
>>
endobj
6 0 obj
<<
/Contents 32 0 R
/Type /Page
/Resources <<
/Font <<
/F1 33 0 R
/F2 34 0 R
/F3 35 0 R
/F4 36 0 R
>>
/XObject <<
/Xf1 37 0 R
>>
>>
/Annots [38 0 R 39 0 R 40 0 R]
/Parent 3 0 R
/MediaBox [0 0 595 842]
>>
endobj
7 0 obj
<<
/CropBox [0 0 612 792]
/Annots [41 0 R 42 0 R]
/Parent 3 0 R
/Contents 43 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Thumb 44 0 R
/Resources <<
/XObject <<
/Im0 45 0 R
>>
/ColorSpace <<
/CS0 [/ICCBased 46 0 R]
/CS1 [/ICCBased 46 0 R]
>>
/Font <<
/T3_0 47 0 R
/T1_0 48 0 R
/T1_1 49 0 R
/T1_2 50 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Properties <<
/MC0 51 0 R
>>
/ExtGState <<
/GS0 52 0 R
>>
>>
/Type /Page
>>
endobj
8 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 0
/Contents 53 0 R
/Rotate 0
/Group 54 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 58 0 R
/TT3 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
9 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 1
/Contents 60 0 R
/Rotate 0
/Group 61 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 58 0 R
/TT2 57 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
10 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 2
/Contents 62 0 R
/Rotate 0
/Group 63 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
11 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 3
/Contents 64 0 R
/Rotate 0
/Group 65 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 58 0 R
/TT2 57 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
12 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 4
/Contents 66 0 R
/Rotate 0
/Group 67 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 58 0 R
/TT3 59 0 R
/C2_0 68 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
13 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 5
/Contents 69 0 R
/Rotate 0
/Group 70 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
14 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 6
/Contents 71 0 R
/Rotate 0
/Group 72 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
/TT3 58 0 R
/C2_0 68 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
15 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 7
/Contents 73 0 R
/Rotate 0
/Group 74 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/C2_0 68 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
16 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 8
/Contents 75 0 R
/Rotate 0
/Group 76 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 58 0 R
/C2_0 68 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
17 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 9
/Contents 77 0 R
/Rotate 0
/Group 78 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
18 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 10
/Contents 79 0 R
/Rotate 0
/Group 80 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 58 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
19 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 11
/Contents 81 0 R
/Rotate 0
/Group 82 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 58 0 R
/TT3 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
20 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 12
/Contents 83 0 R
/Rotate 0
/Group 84 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
21 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 13
/Contents 85 0 R
/Rotate 0
/Group 86 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
/C2_0 68 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
22 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 14
/Contents 87 0 R
/Rotate 0
/Group 88 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 58 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
23 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 15
/Contents 89 0 R
/Rotate 0
/Group 90 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
24 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 16
/Contents 91 0 R
/Rotate 0
/Group 92 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
25 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 17
/Contents 93 0 R
/Rotate 0
/Group 94 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
26 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 18
/Contents 95 0 R
/Rotate 0
/Group 96 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
27 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 19
/Contents 97 0 R
/Rotate 0
/Group 98 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
28 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 20
/Contents 99 0 R
/Rotate 0
/Group 100 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/TT2 59 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
29 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 21
/Contents 101 0 R
/Rotate 0
/Group 102 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
30 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 22
/Contents 103 0 R
/Rotate 0
/Group 104 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
/C2_0 68 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
31 0 obj
<<
/CropBox [0 0 594.96 842.04]
/Parent 3 0 R
/Tabs /S
/StructParents 23
/Contents 105 0 R
/Rotate 0
/Group 106 0 R
/MediaBox [0 0 594.96 842.04]
/Resources <<
/XObject <<
/Fm0 55 0 R
>>
/Font <<
/TT0 56 0 R
/TT1 57 0 R
>>
/ProcSet [/PDF /Text]
>>
/Type /Page
>>
endobj
32 0 obj
<<
/Length 1684
/Filter /FlateDecode
>>
stream
xXIsFV"ĩܒCW٪2b!V"H5!_FZ۾uL$UŖd:(ŏwDUps:c|I
=`ADb+zTĚ$$]Lvr=L'vn6o|E흢k)t&$\h|$luZwŸ
:gAL']\L{^ryYAEMXio,}\k帟\\fV,UF='\':YeIߋIRKZ>Z]o/g&=akۮyjyWwwǃo;[gG-waxR->zMM/oۗ|JϪ8ldJ1\`m}PLM/yr\?zK^q.ε@zN#;)}]"`Vr-hjÏ6v8lLgEҩ*Jd爤Z"H*e$UtlqWYVFdY4ȉ-]d77vz%Pi=kg憸j}FZT BS0]Є)|
_]]1Z'f*OՄCaO07}OI`
. @ )zcuC̯L =f0^gDW0;"[;֦Rm5;
0f5/> s>9g
!F8kf0L
:yd4NL]b9yܓ 1* i!MVi%E=C[ /\d$"kR9_ f?à;-VPa-X
{f=ND(!w K)֙ʵ/[xCGk!2!F$˲cx:x;^ +\Uq)#مfcd;*fA'%֔Jw000T *[ 9fGnrN`gi].锦I; uSY`2=*֠lT9͋'#Ԍ UZ^L#&aCUg_Fl5&I6M+kQϑm-!7\V3Ѭ<+Qr#O;G(MxʃeI'he7^NƢ|`]ҡnsg=%I箖IX@e'k Mq%RNdv 8Y:vpS|=fϮ0zb3j
8x7<*LPflğmY:21hǂ;J.%b}XD[e
T`E 9
wDVLi[]\15iwBMWS=OsY&93Pc^x8U`g
5?bvæƌj/lVѷYx3/ TC?z]?Qp-z8
J^\#x|
ܠnwE6)_fa3?Oc.+'?MWӋR~
endstream
endobj
33 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
34 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
35 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
36 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /HESMWD+LiberationSans
/Encoding /Identity-H
/DescendantFonts [107 0 R]
/ToUnicode 108 0 R
>>
endobj
37 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 109 0 R
>>
/Font <<
/F1 110 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
38 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1016/j.pcad.2015.09.005)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 576 180.98 586]
>>
endobj
39 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1016/j.pcad.2015.09.005)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [305.45 471 492.8 481]
>>
endobj
40 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/cabf58f4-1298-44e0-acb4-ecf3d6d25252)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 391 291.54 401]
>>
endobj
41 0 obj
<<
/Rect [199.164 520.104 312.756 531.096]
/Subtype /Link
/A 111 0 R
/C [1 1 1]
/H /I
/Border [0 0 1]
/Type /Annot
>>
endobj
42 0 obj
<<
/Rect [118.404 395.664 237.756 407.616]
/Subtype /Link
/A 112 0 R
/C [1 1 1]
/H /I
/Border [0 0 1]
/Type /Annot
>>
endobj
43 0 obj
<<
/Length 1525
/Filter /FlateDecode
>>
stream
HV[F~q
܁}K֛K(RUbvMdͥTY9;Ë!R)>lV`~X]l*n_L*gmy:V]RыUktHFyXXOcInXuU#/QbZk09P\&q*6kzw*~ Tgm?ImH^'5Qܼys۹6V~FJ3sX'YcUbִFcd$KlI_,vJ{4_da@QE
k)Kk3rndDEA]4bG3v goz2Au
2](t a1aD68&C2Nš*d@DY8rV{sz|uymxqddaF/b^\
آb'VZ ` i[]uFsx.x@%;I#-GiE_x!AV