%PDF-1.6
%
1 0 obj
<<
/AcroForm 2 0 R
/Lang (EN)
/Metadata 3 0 R
/Names 4 0 R
/Outlines 5 0 R
/OutputIntents [6 0 R]
/PageLabels 7 0 R
/PageMode /UseOutlines
/Pages 8 0 R
/Type /Catalog
/ViewerPreferences <<
/Direction /L2R
>>
>>
endobj
9 0 obj
<<
/Author (Rebecca L. Gavin )
/CreationDate (D:20200522112646+05'30')
/Creator (Springer)
/CrossMarkDomains#5B1#5D (springer.com)
/CrossMarkDomains#5B2#5D (springerlink.com)
/CrossmarkDomainExclusive (true)
/CrossmarkMajorVersionDate (2010-04-23)
/Keywords (Orai1,Endothelial cell,Platelet,Store-operated Ca2+ entry,Tetraspanin,Thrombo-inflammation,Tspan18)
/ModDate (D:20200723204643+05'30')
/Producer (Acrobat Distiller 10.1.8 \(Windows\))
/Subject (Medical Microbiology and Immunology, https://doi.org/10.1007/s00430-020-00678-y)
/Title (Tspan18 is a novel regulator of thrombo-inflammation)
/doi (10.1007/s00430-020-00678-y)
/robots (noindex)
>>
endobj
2 0 obj
<<
/DA (/Helv 0 Tf 0 g )
/DR <<
/Encoding <<
/PDFDocEncoding 10 0 R
>>
/Font <<
/Helv 11 0 R
/ZaDb 12 0 R
>>
>>
/Fields []
>>
endobj
3 0 obj
<<
/Length 30638
/Subtype /XML
/Type /Metadata
>>
stream
2020-05-22T11:26:46+05:30
Springer
2020-07-23T20:46:43+05:30
2020-07-23T20:46:43+05:30
Acrobat Distiller 10.1.8 (Windows)
Orai1,Endothelial cell,Platelet,Store-operated Ca2+ entry,Tetraspanin,Thrombo-inflammation,Tspan18
application/pdf
https://doi.org/10.1007/s00430-020-00678-y
Springer Berlin Heidelberg
Medical Microbiology and Immunology, https://doi.org/10.1007/s00430-020-00678-y
Orai1
Endothelial cell
Platelet
Store-operated Ca2+ entry
Tetraspanin
Thrombo-inflammation
Tspan18
Tspan18 is a novel regulator of thrombo-inflammation
Rebecca L. Gavin
Chek Ziu Koo
Michael G. Tomlinson
10.1007/s00430-020-00678-y
2010-04-23
true
springer.com
springerlink.com
https://doi.org/10.1007/s00430-020-00678-y
10.1007/s00430-020-00678-y
1432-1831
209
4
553
564
journal
Medical Microbiology and Immunology
The Author(s)
2010-04-23
true
10.1007/s00430-020-00678-y
noindex
springer.com
springerlink.com
VoR
uuid:9609dc32-33bd-44ca-936a-564e3ebbbfeb
uuid:214ac503-71e0-49a3-ae0a-114b1ab5c731
default
1
converted
uuid:8cc51706-a7f7-4f50-ade5-c02ec8baac98
converted to PDF/A-2b
pdfToolbox
2020-07-23T20:44:31+05:30
2
B
Michael G. Tomlinson
http://orcid.org/0000-0002-1189-0091
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
Bag AuthorInformation
external
Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
4 0 obj
<<
/Dests 13 0 R
>>
endobj
5 0 obj
<<
/Count 11
/First 14 0 R
/Last 14 0 R
/Type /Outlines
>>
endobj
6 0 obj
<<
/DestOutputProfile 15 0 R
/Info (sRGB IEC61966-2.1)
/OutputCondition (sRGB)
/OutputConditionIdentifier (Custom)
/RegistryName ()
/S /GTS_PDFA1
/Type /OutputIntent
>>
endobj
7 0 obj
<<
/Nums [0 16 0 R]
>>
endobj
8 0 obj
<<
/Count 13
/Kids [17 0 R 18 0 R]
/Type /Pages
>>
endobj
10 0 obj
<<
/Differences [24 /breve /caron /circumflex /dotaccent /hungarumlaut /ogonek /ring /tilde 39
/quotesingle 96 /grave 128 /bullet /dagger /daggerdbl /ellipsis /emdash /endash
/florin /fraction /guilsinglleft /guilsinglright /minus /perthousand /quotedblbase /quotedblleft /quotedblright /quoteleft
/quoteright /quotesinglbase /trademark /fi /fl /Lslash /OE /Scaron /Ydieresis /Zcaron
/dotlessi /lslash /oe /scaron /zcaron 160 /Euro 164 /currency 166
/brokenbar 168 /dieresis /copyright /ordfeminine 172 /logicalnot /.notdef /registered /macron
/degree /plusminus /twosuperior /threesuperior /acute /mu 183 /periodcentered /cedilla /onesuperior
/ordmasculine 188 /onequarter /onehalf /threequarters 192 /Agrave /Aacute /Acircumflex /Atilde
/Adieresis /Aring /AE /Ccedilla /Egrave /Eacute /Ecircumflex /Edieresis /Igrave /Iacute
/Icircumflex /Idieresis /Eth /Ntilde /Ograve /Oacute /Ocircumflex /Otilde /Odieresis /multiply
/Oslash /Ugrave /Uacute /Ucircumflex /Udieresis /Yacute /Thorn /germandbls /agrave /aacute
/acircumflex /atilde /adieresis /aring /ae /ccedilla /egrave /eacute /ecircumflex /edieresis
/igrave /iacute /icircumflex /idieresis /eth /ntilde /ograve /oacute /ocircumflex /otilde
/odieresis /divide /oslash /ugrave /uacute /ucircumflex /udieresis /yacute /thorn /ydieresis]
/Type /Encoding
>>
endobj
11 0 obj
<<
/BaseFont /Helvetica
/Encoding 10 0 R
/Name /Helv
/Subtype /Type1
/Type /Font
>>
endobj
12 0 obj
<<
/BaseFont /ZapfDingbats
/Name /ZaDb
/Subtype /Type1
/Type /Font
>>
endobj
13 0 obj
<<
/Kids [19 0 R 20 0 R]
>>
endobj
14 0 obj
<<
/A 21 0 R
/C [0 0 0]
/Count 10
/F 0
/First 22 0 R
/Last 23 0 R
/Parent 5 0 R
/Title
>>
endobj
15 0 obj
<<
/Length 2574
/Filter /FlateDecode
/N 3
/Range [0 1 0 1 0 1]
>>
stream
HyTSwoɞc
[5laQIBHADED2mtFOE.c}088GNg9w߽ '0 ֠Jb
2y.-;!KZ ^i"L0-
@8(r;q7Ly&Qq4j|9
V)gB0iW8#8wթ8_٥ʨQQj@&A)/g>'K t;\
ӥ$պFZUn(4T%)뫔0C&Zi8bxEB;Pӓ̹Aom?W=
x- [ 0}y)7ta>jT7@tܛ`q2ʀ&6ZLĄ?_yxg)˔zçLU*uSkSeO4?c. R
߁-25 S>ӣVd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L`< "AYA+Cb(R, *T2B-
ꇆnQt}MA0alSx k&^>0|>_',G!"F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VĭKĻYdE"EI2EBGt4MzNr!YK ?%_(0J:EAiQ(()ӔWT6U@P+!~mDeԴ!hӦh/']B/ҏӿ?a0nhF!X8܌kc&5S6lIa2cKMA!E#ƒdV(kel
}}Cq9
N')].uJr
wG xR^[oƜchg`>b$*~ :Eb~,m,-ݖ,Y¬*6X[ݱF=3뭷Y~dó tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:˜O:ϸ8uJqnv=MmR 4
n3ܣkGݯz=[==<=GTB(/S,]6*-W:#7*e^YDY}UjAyT`#D="b{ų+ʯ:!kJ4Gmt}uC%K7YVfFY.=b?SƕƩȺy
چk5%4m7lqlioZlG+Zzmzy]?uuw|"űNwW&e֥ﺱ*|j5kyݭǯg^ykEklD_p߶7Dmo꿻1ml{Mś
nLl<9O [$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD- u`ֲK³8%yhYѹJº;.!
zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs
2F[p(@Xr4Pm8Ww)Km
endstream
endobj
16 0 obj
<<
/S /D
/St 553
>>
endobj
17 0 obj
<<
/Count 6
/Kids [24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R]
/Parent 8 0 R
/Type /Pages
>>
endobj
18 0 obj
<<
/Count 7
/Kids [30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R]
/Parent 8 0 R
/Type /Pages
>>
endobj
19 0 obj
<<
/Limits [(430_2020_678_Article.indd:Anchor 10:159) (430_2020_678_Article.indd:CR29:82)]
/Names [(430_2020_678_Article.indd:Anchor 10:159) [33 0 R /XYZ 305 263 null]
(430_2020_678_Article.indd:Anchor 11:160) [34 0 R /XYZ 50 593 null]
(430_2020_678_Article.indd:Anchor 1:150) [25 0 R /XYZ 50 689 null]
(430_2020_678_Article.indd:Anchor 2:151) [25 0 R /XYZ 50 586 null]
(430_2020_678_Article.indd:Anchor 3:152) [25 0 R /XYZ 50 313 null]
(430_2020_678_Article.indd:Anchor 4:153) [26 0 R /XYZ 50 563 null]
(430_2020_678_Article.indd:Anchor 5:154) [27 0 R /XYZ 50 652 null]
(430_2020_678_Article.indd:Anchor 6:155) [27 0 R /XYZ 305 677 null]
(430_2020_678_Article.indd:Anchor 7:156) [29 0 R /XYZ 305 738 null]
(430_2020_678_Article.indd:Anchor 8:157) [30 0 R /XYZ 305 188 null]
(430_2020_678_Article.indd:Anchor 9:158) [33 0 R /XYZ 50 350 null]
(430_2020_678_Article.indd:CR10:45) [34 0 R /XYZ 50 107 null]
(430_2020_678_Article.indd:CR11:47) [34 0 R /XYZ 305 737 null]
(430_2020_678_Article.indd:CR12:49) [34 0 R /XYZ 305 697 null]
(430_2020_678_Article.indd:CR13:51) [34 0 R /XYZ 305 657 null]
(430_2020_678_Article.indd:CR14:53) [34 0 R /XYZ 305 627 null]
(430_2020_678_Article.indd:CR15:55) [34 0 R /XYZ 305 597 null]
(430_2020_678_Article.indd:CR16:57) [34 0 R /XYZ 305 567 null]
(430_2020_678_Article.indd:CR17:59) [34 0 R /XYZ 305 537 null]
(430_2020_678_Article.indd:CR18:60) [34 0 R /XYZ 305 517 null]
(430_2020_678_Article.indd:CR19:62) [34 0 R /XYZ 305 487 null]
(430_2020_678_Article.indd:CR1:27) [34 0 R /XYZ 50 567 null]
(430_2020_678_Article.indd:CR20:64) [34 0 R /XYZ 305 447 null]
(430_2020_678_Article.indd:CR21:66) [34 0 R /XYZ 305 407 null]
(430_2020_678_Article.indd:CR22:68) [34 0 R /XYZ 305 357 null]
(430_2020_678_Article.indd:CR23:70) [34 0 R /XYZ 305 317 null]
(430_2020_678_Article.indd:CR24:72) [34 0 R /XYZ 305 277 null]
(430_2020_678_Article.indd:CR25:74) [34 0 R /XYZ 305 227 null]
(430_2020_678_Article.indd:CR26:76) [34 0 R /XYZ 305 177 null]
(430_2020_678_Article.indd:CR27:78) [34 0 R /XYZ 305 137 null]
(430_2020_678_Article.indd:CR28:80) [35 0 R /XYZ 50 737 null]
(430_2020_678_Article.indd:CR29:82) [35 0 R /XYZ 50 657 null]
]
>>
endobj
20 0 obj
<<
/Limits [(430_2020_678_Article.indd:CR2:29) (430_2020_678_Article.indd:Sec7:23)]
/Names [(430_2020_678_Article.indd:CR2:29) [34 0 R /XYZ 50 537 null]
(430_2020_678_Article.indd:CR30:84) [35 0 R /XYZ 50 597 null]
(430_2020_678_Article.indd:CR31:86) [35 0 R /XYZ 50 547 null]
(430_2020_678_Article.indd:CR32:88) [35 0 R /XYZ 50 497 null]
(430_2020_678_Article.indd:CR33:90) [35 0 R /XYZ 50 447 null]
(430_2020_678_Article.indd:CR34:92) [35 0 R /XYZ 50 407 null]
(430_2020_678_Article.indd:CR35:94) [35 0 R /XYZ 50 347 null]
(430_2020_678_Article.indd:CR36:96) [35 0 R /XYZ 50 307 null]
(430_2020_678_Article.indd:CR37:98) [35 0 R /XYZ 50 247 null]
(430_2020_678_Article.indd:CR38:100) [35 0 R /XYZ 50 197 null]
(430_2020_678_Article.indd:CR39:102) [35 0 R /XYZ 50 167 null]
(430_2020_678_Article.indd:CR3:31) [34 0 R /XYZ 50 497 null]
(430_2020_678_Article.indd:CR40:104) [35 0 R /XYZ 50 137 null]
(430_2020_678_Article.indd:CR41:106) [35 0 R /XYZ 50 97 null]
(430_2020_678_Article.indd:CR42:108) [35 0 R /XYZ 305 697 null]
(430_2020_678_Article.indd:CR43:109) [35 0 R /XYZ 305 667 null]
(430_2020_678_Article.indd:CR44:111) [35 0 R /XYZ 305 637 null]
(430_2020_678_Article.indd:CR45:112) [35 0 R /XYZ 305 577 null]
(430_2020_678_Article.indd:CR46:113) [35 0 R /XYZ 305 517 null]
(430_2020_678_Article.indd:CR47:115) [35 0 R /XYZ 305 467 null]
(430_2020_678_Article.indd:CR48:116) [35 0 R /XYZ 305 427 null]
(430_2020_678_Article.indd:CR49:118) [35 0 R /XYZ 305 377 null]
(430_2020_678_Article.indd:CR4:33) [34 0 R /XYZ 50 467 null]
(430_2020_678_Article.indd:CR50:120) [35 0 R /XYZ 305 327 null]
(430_2020_678_Article.indd:CR51:122) [35 0 R /XYZ 305 277 null]
(430_2020_678_Article.indd:CR52:124) [35 0 R /XYZ 305 237 null]
(430_2020_678_Article.indd:CR53:126) [35 0 R /XYZ 305 207 null]
(430_2020_678_Article.indd:CR54:128) [35 0 R /XYZ 305 157 null]
(430_2020_678_Article.indd:CR55:130) [36 0 R /XYZ 50 707 null]
(430_2020_678_Article.indd:CR56:132) [36 0 R /XYZ 50 657 null]
(430_2020_678_Article.indd:CR57:134) [36 0 R /XYZ 50 617 null]
(430_2020_678_Article.indd:CR58:136) [36 0 R /XYZ 50 567 null]
(430_2020_678_Article.indd:CR59:138) [36 0 R /XYZ 50 527 null]
(430_2020_678_Article.indd:CR5:35) [34 0 R /XYZ 50 387 null]
(430_2020_678_Article.indd:CR60:140) [36 0 R /XYZ 50 497 null]
(430_2020_678_Article.indd:CR61:142) [36 0 R /XYZ 305 707 null]
(430_2020_678_Article.indd:CR62:144) [36 0 R /XYZ 305 647 null]
(430_2020_678_Article.indd:CR63:146) [36 0 R /XYZ 305 607 null]
(430_2020_678_Article.indd:CR64:148) [36 0 R /XYZ 305 577 null]
(430_2020_678_Article.indd:CR6:37) [34 0 R /XYZ 50 357 null]
(430_2020_678_Article.indd:CR7:39) [34 0 R /XYZ 50 267 null]
(430_2020_678_Article.indd:CR8:41) [34 0 R /XYZ 50 217 null]
(430_2020_678_Article.indd:CR9:43) [34 0 R /XYZ 50 167 null]
(430_2020_678_Article.indd:FPar1:24) [33 0 R /XYZ 305 156 null]
(430_2020_678_Article.indd:FPar2:25) [33 0 R /XYZ 305 126 null]
(430_2020_678_Article.indd:Fig1:3) [26 0 R /XYZ 50 145 null]
(430_2020_678_Article.indd:Fig2:7) [28 0 R /XYZ 50 736 null]
(430_2020_678_Article.indd:Fig3:10) [30 0 R /XYZ 50 736 null]
(430_2020_678_Article.indd:Fig4:13) [31 0 R /XYZ 50 263 null]
(430_2020_678_Article.indd:Fig5:16) [32 0 R /XYZ 50 346 null]
(430_2020_678_Article.indd:Fig6:19) [33 0 R /XYZ 50 445 null]
(430_2020_678_Article.indd:MO1:4) [26 0 R /XYZ 204 337 null]
(430_2020_678_Article.indd:MO2:8) [27 0 R /XYZ 359 388 null]
(430_2020_678_Article.indd:MO3:12) [29 0 R /XYZ 583 299 null]
(430_2020_678_Article.indd:MO4:15) [30 0 R /XYZ 50 375 null]
(430_2020_678_Article.indd:MO5:18) [30 0 R /XYZ 50 375 null]
(430_2020_678_Article.indd:MO6:21) [30 0 R /XYZ 50 188 null]
(430_2020_678_Article.indd:Sec1:1) [25 0 R /XYZ 50 313 null]
(430_2020_678_Article.indd:Sec2:2) [26 0 R /XYZ 50 563 null]
(430_2020_678_Article.indd:Sec3:5) [27 0 R /XYZ 50 652 null]
(430_2020_678_Article.indd:Sec4:6) [27 0 R /XYZ 305 677 null]
(430_2020_678_Article.indd:Sec5:9) [29 0 R /XYZ 305 738 null]
(430_2020_678_Article.indd:Sec6:22) [30 0 R /XYZ 305 188 null]
(430_2020_678_Article.indd:Sec7:23) [33 0 R /XYZ 50 350 null]
]
>>
endobj
21 0 obj
<<
/D (430_2020_678_Article.indd:Anchor 1:150)
/S /GoTo
>>
endobj
22 0 obj
<<
/A 37 0 R
/C [0 0 0]
/Count 0
/F 0
/Next 38 0 R
/Parent 14 0 R
/Title
>>
endobj
23 0 obj
<<
/A 39 0 R
/C [0 0 0]
/Count 0
/F 0
/Parent 14 0 R
/Prev 40 0 R
/Title
>>
endobj
24 0 obj
<<
/Contents 41 0 R
/Type /Page
/Resources <<
/Font <<
/F1 42 0 R
/F2 43 0 R
/F3 44 0 R
/F4 45 0 R
>>
/XObject <<
/Xf1 46 0 R
>>
>>
/Annots [47 0 R 48 0 R 49 0 R]
/Parent 17 0 R
/MediaBox [0 0 595 842]
>>
endobj
25 0 obj
<<
/Annots [50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R]
/Contents [59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R]
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 17 0 R
/Resources 67 0 R
/Rotate 0
/Thumb 68 0 R
/Type /Page
>>
endobj
26 0 obj
<<
/Annots [69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R
79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R]
/Contents 87 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 17 0 R
/Resources 88 0 R
/Rotate 0
/Thumb 89 0 R
/Type /Page
>>
endobj
27 0 obj
<<
/Annots [90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R
100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R 109 0 R
110 0 R 111 0 R 112 0 R 113 0 R 114 0 R]
/Contents 115 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 17 0 R
/Resources 116 0 R
/Rotate 0
/Thumb 117 0 R
/Type /Page
>>
endobj
28 0 obj
<<
/Annots [118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R]
/Contents 126 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 17 0 R
/Resources 127 0 R
/Rotate 0
/Thumb 128 0 R
/Type /Page
>>
endobj
29 0 obj
<<
/Annots [129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R
139 0 R 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R
149 0 R 150 0 R 151 0 R 152 0 R 153 0 R 154 0 R 155 0 R]
/Contents 156 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 17 0 R
/Resources 157 0 R
/Rotate 0
/Thumb 158 0 R
/Type /Page
>>
endobj
30 0 obj
<<
/Annots [159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R]
/Contents 169 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 18 0 R
/Resources 170 0 R
/Rotate 0
/Thumb 171 0 R
/Type /Page
>>
endobj
31 0 obj
<<
/Annots [172 0 R 173 0 R 174 0 R 175 0 R]
/Contents 176 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 18 0 R
/Resources 177 0 R
/Rotate 0
/Thumb 178 0 R
/Type /Page
>>
endobj
32 0 obj
<<
/Annots [179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R]
/Contents 189 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 18 0 R
/Resources 190 0 R
/Rotate 0
/Thumb 191 0 R
/Type /Page
>>
endobj
33 0 obj
<<
/Annots [192 0 R 193 0 R 194 0 R 195 0 R]
/Contents 196 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 18 0 R
/Resources 197 0 R
/Rotate 0
/Thumb 198 0 R
/Type /Page
>>
endobj
34 0 obj
<<
/Annots [199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R
209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R
219 0 R 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R 225 0 R 226 0 R 227 0 R 228 0 R
229 0 R 230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R 238 0 R
239 0 R 240 0 R 241 0 R 242 0 R 243 0 R]
/Contents 244 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 18 0 R
/Resources 245 0 R
/Rotate 0
/Thumb 246 0 R
/Type /Page
>>
endobj
35 0 obj
<<
/Annots [247 0 R 248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R
257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R
267 0 R 268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R 275 0 R 276 0 R
277 0 R 278 0 R 279 0 R 280 0 R]
/Contents 281 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 18 0 R
/Resources 282 0 R
/Rotate 0
/Thumb 283 0 R
/Type /Page
>>
endobj
36 0 obj
<<
/Annots [284 0 R 285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R 291 0 R 292 0 R 293 0 R
294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R]
/Contents 301 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 18 0 R
/Resources 302 0 R
/Rotate 0
/Thumb 303 0 R
/Type /Page
>>
endobj
37 0 obj
<<
/D (430_2020_678_Article.indd:Anchor 2:151)
/S /GoTo
>>
endobj
38 0 obj
<<
/A 304 0 R
/C [0 0 0]
/Count 0
/F 0
/Next 305 0 R
/Parent 14 0 R
/Prev 22 0 R
/Title
>>
endobj
39 0 obj
<<
/D (430_2020_678_Article.indd:Anchor 11:160)
/S /GoTo
>>
endobj
40 0 obj
<<
/A 306 0 R
/C [0 0 0]
/Count 0
/F 0
/Next 23 0 R
/Parent 14 0 R
/Prev 307 0 R
/Title
>>
endobj
41 0 obj
<<
/Length 1692
/Filter /FlateDecode
>>
stream
xX[sF2CZw>M`<5fDMyA I&۾7]C|;.XHe*e)I
]iAmEnRhn.]g/W70506hCd_teRYV&mM׳y,woٛ3oSu5e]QV&2`rZ5uw.oq?Uu~[\*TV0^|eȼ7W+D#]XOo,s`{k5 ^#Y玪TNuz`NuT%Q$V.$RѼo.E1VDH+&r{.oZO{|}uE-Vrj;itxL%U97{a[s|\s\VnWL݃pGa{oG]/#\kq,^/W I{3M|msfYdD,ޛkke2@,bS[|4p%ztveHU,ʴVC\P2MwY츛hj+h3ȊSL4Ֆ~Lfq^
Զi%6[7@-i4N4'3H.x-{3#cx5|;dD[|S SxC~'s\
<1K5FnLdf@GCx9EsƖ9z0173ŸuOl<}x,=>YUjSf'j``!0}b>9Cgf8P股vf
t_X[?192D$0m108KS,j+Z}ꣁ94P9Jt3Q>09&AfchTa[p{f=AD(!ҷ`WZg&*_[xCǘo2!F$˲HgމxX
c^ /\mRN>gFH)rT)LD648)ٝLzD̅y}@Q9lUʭO:Au,!M:Mtp<٧ez,*mA6n^1fv^)9"F@HU.*OG0:8눭0n$<ߦiE̓R6͐!hV(Qr#Rv湏Q Mxy[$A4/'gQ-Kt#|NSĮ2vjr'ON@9H#|3aDvҩÕh5qpu>Df)P@0-6c=&\Xc}oAC&
lDZeض^f0#T3(<@1ȋɳ`1MEkºP>4;&@+)i!`.UU5d~В5'y& %,h>
!FGqAntCqݘ]%vh9};g8l~;9ӐAgA/>
endobj
43 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
44 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
45 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /BMNUKR+LiberationSans
/Encoding /Identity-H
/DescendantFonts [308 0 R]
/ToUnicode 309 0 R
>>
endobj
46 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 310 0 R
>>
/Font <<
/F1 311 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
47 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1007/s00430-020-00678-y)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 576 188.19 586]
>>
endobj
48 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1007/s00430-020-00678-y)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [322.69 471 517.25 481]
>>
endobj
49 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/52f3f848-a9f6-4290-8eef-fd1e1fb4cd24)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 391 291.54 401]
>>
endobj
50 0 obj
<<
/A 312 0 R
/AP <<
/N 313 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [294.622 652.825 306.957 640.491]
/Subtype /Link
/Type /Annot
>>
endobj
51 0 obj
<<
/AP <<
/N 314 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest (430_2020_678_Article.indd:CR1:27)
/F 4
/H /N
/Rect [88.871 259.871 93.9733 244.781]
/Subtype /Link
/Type /Annot
>>
endobj
52 0 obj
<<
/AP <<
/N 315 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest (430_2020_678_Article.indd:CR3:31)
/F 4
/H /N
/Rect [99.0755 259.871 104.178 244.781]
/Subtype /Link
/Type /Annot
>>
endobj
53 0 obj
<<
/AP <<
/N 316 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest (430_2020_678_Article.indd:CR2:29)
/F 4
/H /N
/Rect [420.967 297.371 426.151 282.281]
/Subtype /Link
/Type /Annot
>>
endobj
54 0 obj
<<
/AP <<
/N 317 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest (430_2020_678_Article.indd:CR2:29)
/F 4
/H /N
/Rect [421.932 184.871 426.982 169.781]
/Subtype /Link
/Type /Annot
>>
endobj
55 0 obj
<<
/AP <<
/N 318 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest (430_2020_678_Article.indd:CR4:33)
/F 4
/H /N
/Rect [442.167 159.871 447.222 144.781]
/Subtype /Link
/Type /Annot
>>
endobj
56 0 obj
<<
/AP <<
/N 317 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest (430_2020_678_Article.indd:CR1:27)
/F 4
/H /N
/Rect [401.696 122.371 406.746 107.281]
/Subtype /Link
/Type /Annot
>>
endobj
57 0 obj
<<
/AP <<
/N 319 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest (430_2020_678_Article.indd:CR3:31)
/F 4
/H /N
/Rect [411.796 122.371 416.846 107.281]
/Subtype /Link
/Type /Annot
>>
endobj
58 0 obj
<<
/A 320 0 R
/AP <<
/N 321 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [513.673 726.606 546.241 694.021]
/Subtype /Link
/Type /Annot
>>
endobj
59 0 obj
<<
/Length 1705
/Filter /FlateDecode
>>
stream
HWێ5,8'#]#i$PKqW%r-RvEuޮ)AP-@aٻdGnDw{kH$II<7+Bi+ђ9ڙ;aa}s2[ibǰ"C&e^gEadKf8z*ě)elβXKɵl,O{Zmښ J
.pN\%BX 0ɧAy\ "k^Yy0ISs)vM(rغL! Em,wt`xI?Xs`Q!V `AFP.dk%|5`3hŢi3hϤN;d!n"siY|iY[[p>]ͣbuL26x]J+UIes;J*[BX|/zv14 8{ lsy~vt[]T^B=CΕT%I-_d
rvM^@
Rjg`#|嗫e,v}7MW_? J^~")#/(Vڼ8wۺ\%bRp'ŐfhmSSNY'e>OwcZ<>*is2bFϥZ(*̹o24tcXҹdr Ph"2A!\d1##eQbW3==۴U?} xfG"Cgkq8aVL=֤--Lv0
\OmdO~k'nj*pU]8lC#H#r;NWs+k9u`(ļER8>̽1zX@3,.[ bڲ,6uɺa6Hm&FGf FZ7cps"浮8{d"r`9 TeL{VopZ?B+Lkpn:fu;m0v*9$ ͢}\Akm~ѸtA)
Q~Sf627;{HPzi*v7rhz+1}ќTPU1V#eTnnrwN#?VDX_Qu 3hQMc]U֏Jv;<:NAN'Wt$؇tAT
[P.ۻPz3x#3NA4G
c.
lIK
~` Hkg|
endstream
endobj
60 0 obj
<<
/Length 1678
/Filter /FlateDecode
>>
stream
HWێEyi"EB$y@<ǽvL6ˇ"puDV=UN*o &r_YV"
?K2<Ƌo7~t$>"< R%~nD *f~UZfn {+|%$Fi_lBgyʄkau6.u:iuŀN^;Ѻ{vj
KM8jUkxZzuO3bt/O
k{60 7|/M^بVn?n~V&?c=@N1Źw<;TdwGe^7VZ~<; Վ#{'deVWɭ?Zsĸ1o]%h
]=v Siॅ"cwr/\ *Fh0F(bg@;!И Ӊ'ƃd<