Zonisamide as a treatment for partial epileptic seizures: a systematic review

Research output: Contribution to journalReview articlepeer-review


External organisations

  • Birmingham and Solihull Mental Health NHS Foundation Trust


Although the majority of people with epilepsy have a good prognosis and their seizures can be well controlled with pharmacotherapy, up to one-third of patients can develop drug-resistant epilepsy, especially those patients with partial seizures. This unmet need has driven considerable efforts over the last few decades aimed at developing and testing newer antiepileptic agents to improve seizure control. One of the most promising antiepileptic drugs of the new generation is zonisamide, a benzisoxazole derivative chemically unrelated to other anticonvulsant agents. In this article, the authors present the results of a systematic literature review summarizing the current evidence on the efficacy and tolerability of zonisamide for the treatment of partial seizures. Of particular interest within this updated review are the recent data on the use of zonisamide as monotherapy, as they might open new therapeutic avenues.


Original languageEnglish
Pages (from-to)276-88
Number of pages13
JournalAdvances in therapy
Issue number3
Publication statusPublished - Mar 2014


  • Anticonvulsants/therapeutic use, Epilepsies, Partial/drug therapy, Humans, Isoxazoles/therapeutic use, Treatment Outcome, Zonisamide