YieJ (CbrC) mediates CreBC-dependent Colicin E2 Tolerance in Escherichia coli.

Research output: Contribution to journalArticle

Authors

  • SJ Cariss
  • Mala Patel
  • Y Takebayashi
  • MB Avison

Colleges, School and Institutes

Abstract

Colicin E2 tolerant (known as Cet2) Escherichia coli K-12 mutants over-produce an inner membrane protein, CreD, which is believed to cause the Cet2 phenotype. Here we show that over-production of CreD in a Cet2 strain results from hyper-activation of the CreBC two-component regulator, but CreD over-production is not responsible for the Cet2 phenotype. Through microarray analysis, gene knockout and over-expression studies, we show that over-expression of another CreBC-regulated gene, yieJ (also known as cbrC) causes the Cet2 phenotype.

Details

Original languageEnglish
Pages (from-to)3329-36
Number of pages8
JournalJournal of Bacteriology
Publication statusPublished - 23 Apr 2010