X-ray tomographic imaging of tensile deformation modes of electrospun biodegradable polyester fibres

Research output: Contribution to journalArticle

Standard

X-ray tomographic imaging of tensile deformation modes of electrospun biodegradable polyester fibres. / Maksimcuka, Jekaterina; Obata, Akiko; Sampson, William W; Blanc, Remi; Gao, Chunxia; Withers, Philip John; Tsigkou, Olga; Kasuga, Toshihiro; Lee, Peter D; Poologasundarampillai, Gowsihan.

In: Frontiers in Materials, Vol. 4, 43, 21.12.2017.

Research output: Contribution to journalArticle

Harvard

APA

Maksimcuka, J., Obata, A., Sampson, W. W., Blanc, R., Gao, C., Withers, P. J., Tsigkou, O., Kasuga, T., Lee, P. D., & Poologasundarampillai, G. (2017). X-ray tomographic imaging of tensile deformation modes of electrospun biodegradable polyester fibres. Frontiers in Materials, 4, [43]. https://doi.org/10.3389/fmats.2017.00043

Vancouver

Author

Maksimcuka, Jekaterina ; Obata, Akiko ; Sampson, William W ; Blanc, Remi ; Gao, Chunxia ; Withers, Philip John ; Tsigkou, Olga ; Kasuga, Toshihiro ; Lee, Peter D ; Poologasundarampillai, Gowsihan. / X-ray tomographic imaging of tensile deformation modes of electrospun biodegradable polyester fibres. In: Frontiers in Materials. 2017 ; Vol. 4.

Bibtex

@article{c874ad7e3b3048c182d45b59bad28972,
title = "X-ray tomographic imaging of tensile deformation modes of electrospun biodegradable polyester fibres",
abstract = "Electrospinning allows the production of fibrous networks for tissue engineering, drug delivery, and wound healing in health care. It enables the production of constructs with large surface area and a fibrous morphology that closely resembles the extracellular matrix of many tissues. A fibrous structure not only promotes cell attachment and tissue formation but could also lead to very interesting mechanical properties. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) is a biodegradable polyester that exhibits a large (>400%) elongation before failure. In this study, synchrotron X-ray phase contrast imaging was performed during tensile deformation to failure on a non-woven fiber mat of P(3HB-co-4HB) fibers. Significant reorientation of the fibers in the straining direction was observed, followed by localized necking and eventual failure. From an original average fiber diameter of 4.3 µm, a bimodal distribution of fiber diameter (modal diameters of 1.9 and 3.7 µm) formed after tensile deformation. Extensive localized necking (thinning) of fibers between (thicker) fiber–fiber contacts was found to be the cause for non-uniform thinning of the fibers, a phenomenon that is expected but has not been observed in 3D previously. The data presented here have implications not only in tissue regeneration but for fibrous materials in general.",
author = "Jekaterina Maksimcuka and Akiko Obata and Sampson, {William W} and Remi Blanc and Chunxia Gao and Withers, {Philip John} and Olga Tsigkou and Toshihiro Kasuga and Lee, {Peter D} and Gowsihan Poologasundarampillai",
year = "2017",
month = dec,
day = "21",
doi = "10.3389/fmats.2017.00043",
language = "English",
volume = "4",
journal = "Frontiers in Materials",
issn = "2296-8016",
publisher = "Frontiers",

}

RIS

TY - JOUR

T1 - X-ray tomographic imaging of tensile deformation modes of electrospun biodegradable polyester fibres

AU - Maksimcuka, Jekaterina

AU - Obata, Akiko

AU - Sampson, William W

AU - Blanc, Remi

AU - Gao, Chunxia

AU - Withers, Philip John

AU - Tsigkou, Olga

AU - Kasuga, Toshihiro

AU - Lee, Peter D

AU - Poologasundarampillai, Gowsihan

PY - 2017/12/21

Y1 - 2017/12/21

N2 - Electrospinning allows the production of fibrous networks for tissue engineering, drug delivery, and wound healing in health care. It enables the production of constructs with large surface area and a fibrous morphology that closely resembles the extracellular matrix of many tissues. A fibrous structure not only promotes cell attachment and tissue formation but could also lead to very interesting mechanical properties. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) is a biodegradable polyester that exhibits a large (>400%) elongation before failure. In this study, synchrotron X-ray phase contrast imaging was performed during tensile deformation to failure on a non-woven fiber mat of P(3HB-co-4HB) fibers. Significant reorientation of the fibers in the straining direction was observed, followed by localized necking and eventual failure. From an original average fiber diameter of 4.3 µm, a bimodal distribution of fiber diameter (modal diameters of 1.9 and 3.7 µm) formed after tensile deformation. Extensive localized necking (thinning) of fibers between (thicker) fiber–fiber contacts was found to be the cause for non-uniform thinning of the fibers, a phenomenon that is expected but has not been observed in 3D previously. The data presented here have implications not only in tissue regeneration but for fibrous materials in general.

AB - Electrospinning allows the production of fibrous networks for tissue engineering, drug delivery, and wound healing in health care. It enables the production of constructs with large surface area and a fibrous morphology that closely resembles the extracellular matrix of many tissues. A fibrous structure not only promotes cell attachment and tissue formation but could also lead to very interesting mechanical properties. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) is a biodegradable polyester that exhibits a large (>400%) elongation before failure. In this study, synchrotron X-ray phase contrast imaging was performed during tensile deformation to failure on a non-woven fiber mat of P(3HB-co-4HB) fibers. Significant reorientation of the fibers in the straining direction was observed, followed by localized necking and eventual failure. From an original average fiber diameter of 4.3 µm, a bimodal distribution of fiber diameter (modal diameters of 1.9 and 3.7 µm) formed after tensile deformation. Extensive localized necking (thinning) of fibers between (thicker) fiber–fiber contacts was found to be the cause for non-uniform thinning of the fibers, a phenomenon that is expected but has not been observed in 3D previously. The data presented here have implications not only in tissue regeneration but for fibrous materials in general.

U2 - 10.3389/fmats.2017.00043

DO - 10.3389/fmats.2017.00043

M3 - Article

VL - 4

JO - Frontiers in Materials

JF - Frontiers in Materials

SN - 2296-8016

M1 - 43

ER -