Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence

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Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence. / Talaber, G; Kvell, K; Varecza, Z; Boldizsar, F; Parnell, Sonia; Jenkinson, Eric; Anderson, Graham; Berki, T; Pongracz, JE.

In: Rejuvenation Research, Vol. 14, No. 3, 01.06.2011, p. 241-248.

Research output: Contribution to journalArticle

Harvard

Talaber, G, Kvell, K, Varecza, Z, Boldizsar, F, Parnell, S, Jenkinson, E, Anderson, G, Berki, T & Pongracz, JE 2011, 'Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence', Rejuvenation Research, vol. 14, no. 3, pp. 241-248. https://doi.org/10.1089/rej.2010.1110

APA

Talaber, G., Kvell, K., Varecza, Z., Boldizsar, F., Parnell, S., Jenkinson, E., Anderson, G., Berki, T., & Pongracz, JE. (2011). Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence. Rejuvenation Research, 14(3), 241-248. https://doi.org/10.1089/rej.2010.1110

Vancouver

Author

Talaber, G ; Kvell, K ; Varecza, Z ; Boldizsar, F ; Parnell, Sonia ; Jenkinson, Eric ; Anderson, Graham ; Berki, T ; Pongracz, JE. / Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence. In: Rejuvenation Research. 2011 ; Vol. 14, No. 3. pp. 241-248.

Bibtex

@article{2b1027f5e3af42489bd2e54dd8cc0250,
title = "Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence",
abstract = "Glucocorticoids are widely used immunosuppressive drugs in treatment of autoimmune diseases and hematological malignancies. Glucocorticoids are particularly effective immune suppressants, because they induce rapid peripheral T cell and thymocyte apoptosis resulting in impaired T cell-dependent immune responses. Although glucocorticoids can induce apoptotic cell death directly in developing thymocytes, how exogenous glucocorticoids affect the thymic epithelial network that provides the microenvironment for T cell development is still largely unknown. In the present work, we show that primary thymic epithelial cells (TECs) express glucocorticoid receptors and that high-dosage dexamethasone induces degeneration of the thymic epithelium within 24 h of treatment. Changes in organ morphology are accompanied by a decrease in the TEC transcription factor FoxN1 and its regulator Wnt-4 parallel with upregulation of lamina-associated polypeptide 2 alpha and peroxisome proliferator activator receptor gamma, two characteristic molecular markers for adipose thymic involution. Overexpression of Wnt-4, however, can prevent upregulation of adipose differentiation-related aging markers, suggesting an important role of Wnt-4 in thymic senescence.",
author = "G Talaber and K Kvell and Z Varecza and F Boldizsar and Sonia Parnell and Eric Jenkinson and Graham Anderson and T Berki and JE Pongracz",
year = "2011",
month = jun,
day = "1",
doi = "10.1089/rej.2010.1110",
language = "English",
volume = "14",
pages = "241--248",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert",
number = "3",

}

RIS

TY - JOUR

T1 - Wnt-4 Protects Thymic Epithelial Cells Against Dexamethasone-Induced Senescence

AU - Talaber, G

AU - Kvell, K

AU - Varecza, Z

AU - Boldizsar, F

AU - Parnell, Sonia

AU - Jenkinson, Eric

AU - Anderson, Graham

AU - Berki, T

AU - Pongracz, JE

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Glucocorticoids are widely used immunosuppressive drugs in treatment of autoimmune diseases and hematological malignancies. Glucocorticoids are particularly effective immune suppressants, because they induce rapid peripheral T cell and thymocyte apoptosis resulting in impaired T cell-dependent immune responses. Although glucocorticoids can induce apoptotic cell death directly in developing thymocytes, how exogenous glucocorticoids affect the thymic epithelial network that provides the microenvironment for T cell development is still largely unknown. In the present work, we show that primary thymic epithelial cells (TECs) express glucocorticoid receptors and that high-dosage dexamethasone induces degeneration of the thymic epithelium within 24 h of treatment. Changes in organ morphology are accompanied by a decrease in the TEC transcription factor FoxN1 and its regulator Wnt-4 parallel with upregulation of lamina-associated polypeptide 2 alpha and peroxisome proliferator activator receptor gamma, two characteristic molecular markers for adipose thymic involution. Overexpression of Wnt-4, however, can prevent upregulation of adipose differentiation-related aging markers, suggesting an important role of Wnt-4 in thymic senescence.

AB - Glucocorticoids are widely used immunosuppressive drugs in treatment of autoimmune diseases and hematological malignancies. Glucocorticoids are particularly effective immune suppressants, because they induce rapid peripheral T cell and thymocyte apoptosis resulting in impaired T cell-dependent immune responses. Although glucocorticoids can induce apoptotic cell death directly in developing thymocytes, how exogenous glucocorticoids affect the thymic epithelial network that provides the microenvironment for T cell development is still largely unknown. In the present work, we show that primary thymic epithelial cells (TECs) express glucocorticoid receptors and that high-dosage dexamethasone induces degeneration of the thymic epithelium within 24 h of treatment. Changes in organ morphology are accompanied by a decrease in the TEC transcription factor FoxN1 and its regulator Wnt-4 parallel with upregulation of lamina-associated polypeptide 2 alpha and peroxisome proliferator activator receptor gamma, two characteristic molecular markers for adipose thymic involution. Overexpression of Wnt-4, however, can prevent upregulation of adipose differentiation-related aging markers, suggesting an important role of Wnt-4 in thymic senescence.

U2 - 10.1089/rej.2010.1110

DO - 10.1089/rej.2010.1110

M3 - Article

C2 - 21453014

VL - 14

SP - 241

EP - 248

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

IS - 3

ER -