Wide-Ranging Genomic Effects of Plasticisers and Related Compounds

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Wide-Ranging Genomic Effects of Plasticisers and Related Compounds. / Turan Jurdzinski, Nil; Cartwright, LS; Waring, Rosemary; Ramsden, David.

In: Current Drug Metabolism, Vol. 9, No. 4, 01.05.2008, p. 285-303.

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@article{7decbc88ba9242bdb03f4aaee6c22206,
title = "Wide-Ranging Genomic Effects of Plasticisers and Related Compounds",
abstract = "The effects of four compounds, bis(2-ethylhexyl)phthalate (BEHP); diisodecylphthalate (DIP); 4-n-octylphenol (OP); 4-chloro-3-methylphenol (CMP), on gene expression (steady-state mRNA levels) across the whole human genome were studied in human TE671 cells. Effects were studied using the Affymetrics GeneChip (R) Human Genome U133 Plus 2.0, HG-U133 Plus 2.0 arrays, The array analyses the expression of 47,000 transcripts and variants, including similar to 38,500 well characterised. All four compounds exerted statistically significant actions, affecting between 4 and 6.5% of all genes. Each compound had its own expression signature. In most instances where there was an effect steady-state mRNA levels were decreased, although not always. CMP reatment caused most increases in mRNA levels.. A mixture of DIP and CMP caused fewer changes in mRNA levels than either of the individual compounds.",
author = "{Turan Jurdzinski}, Nil and LS Cartwright and Rosemary Waring and David Ramsden",
year = "2008",
month = may,
day = "1",
doi = "10.2174/138920008784220655",
language = "English",
volume = "9",
pages = "285--303",
journal = "Current Drug Metabolism",
issn = "1389-2002",
publisher = "Bentham Science Publishers",
number = "4",

}

RIS

TY - JOUR

T1 - Wide-Ranging Genomic Effects of Plasticisers and Related Compounds

AU - Turan Jurdzinski, Nil

AU - Cartwright, LS

AU - Waring, Rosemary

AU - Ramsden, David

PY - 2008/5/1

Y1 - 2008/5/1

N2 - The effects of four compounds, bis(2-ethylhexyl)phthalate (BEHP); diisodecylphthalate (DIP); 4-n-octylphenol (OP); 4-chloro-3-methylphenol (CMP), on gene expression (steady-state mRNA levels) across the whole human genome were studied in human TE671 cells. Effects were studied using the Affymetrics GeneChip (R) Human Genome U133 Plus 2.0, HG-U133 Plus 2.0 arrays, The array analyses the expression of 47,000 transcripts and variants, including similar to 38,500 well characterised. All four compounds exerted statistically significant actions, affecting between 4 and 6.5% of all genes. Each compound had its own expression signature. In most instances where there was an effect steady-state mRNA levels were decreased, although not always. CMP reatment caused most increases in mRNA levels.. A mixture of DIP and CMP caused fewer changes in mRNA levels than either of the individual compounds.

AB - The effects of four compounds, bis(2-ethylhexyl)phthalate (BEHP); diisodecylphthalate (DIP); 4-n-octylphenol (OP); 4-chloro-3-methylphenol (CMP), on gene expression (steady-state mRNA levels) across the whole human genome were studied in human TE671 cells. Effects were studied using the Affymetrics GeneChip (R) Human Genome U133 Plus 2.0, HG-U133 Plus 2.0 arrays, The array analyses the expression of 47,000 transcripts and variants, including similar to 38,500 well characterised. All four compounds exerted statistically significant actions, affecting between 4 and 6.5% of all genes. Each compound had its own expression signature. In most instances where there was an effect steady-state mRNA levels were decreased, although not always. CMP reatment caused most increases in mRNA levels.. A mixture of DIP and CMP caused fewer changes in mRNA levels than either of the individual compounds.

U2 - 10.2174/138920008784220655

DO - 10.2174/138920008784220655

M3 - Article

C2 - 18473747

VL - 9

SP - 285

EP - 303

JO - Current Drug Metabolism

JF - Current Drug Metabolism

SN - 1389-2002

IS - 4

ER -