TY - JOUR
T1 - White blood cell count and the metabolic syndrome in older Chinese: The Guangzhou Biobank Cohort Study
AU - Lao, XQ
AU - Thomas, Graham
AU - Jiang, C
AU - Zhang, W
AU - Adab, Peymane
AU - Lam, TH
AU - Cheng, Kar
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Aims: To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population.
Methods: Three thousand and twenty men and 7256 women aged 50-85 years were recruited and received a medical check-Lip including measurement of complete blood count, blood pressure, obesity indices, fasting total, LDL-, HIDL-cholesterol, triglycerides. glucose and C-reactive protein (CRP). Information on socioeconomic and lifestyle factors was also collected.
Results: Vascular risk factors including waist circumference. body mass index, triglyceride, total-, LDL-cholesterol, CRP and systolic and diastolic blood pressures were all positively associated with WBC in both men and women (1) from 0.0085 to <0.001). The risk of MS increased significantly with higher total WBC, with adjusted odds ratios (95% confident interval) for second and third tertiles of 1.86 (1.43, 2.42), 2.56 (1.98, 3.32) in men and 1.67 (1.46, 1.90), 2.66 (2.34, 3.03) in women, respectively. Neutrophil and lymphocyte were strongly correlated with total WBC and showed similar association with the MS.
Conclusion: There is a strong relationship between total WBC. neutrophil and lymphocyte and the constellation of MS components and associated vascular risk in this older Chinese Population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
AB - Aims: To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population.
Methods: Three thousand and twenty men and 7256 women aged 50-85 years were recruited and received a medical check-Lip including measurement of complete blood count, blood pressure, obesity indices, fasting total, LDL-, HIDL-cholesterol, triglycerides. glucose and C-reactive protein (CRP). Information on socioeconomic and lifestyle factors was also collected.
Results: Vascular risk factors including waist circumference. body mass index, triglyceride, total-, LDL-cholesterol, CRP and systolic and diastolic blood pressures were all positively associated with WBC in both men and women (1) from 0.0085 to <0.001). The risk of MS increased significantly with higher total WBC, with adjusted odds ratios (95% confident interval) for second and third tertiles of 1.86 (1.43, 2.42), 2.56 (1.98, 3.32) in men and 1.67 (1.46, 1.90), 2.66 (2.34, 3.03) in women, respectively. Neutrophil and lymphocyte were strongly correlated with total WBC and showed similar association with the MS.
Conclusion: There is a strong relationship between total WBC. neutrophil and lymphocyte and the constellation of MS components and associated vascular risk in this older Chinese Population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
KW - Vascular risk factors
KW - Metabolic syndrome
KW - White blood cell
KW - Chinese
U2 - 10.1016/j.atherosclerosis.2007.12.053
DO - 10.1016/j.atherosclerosis.2007.12.053
M3 - Article
C2 - 18295770
VL - 201
SP - 418
EP - 424
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -
