Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study

Research output: Contribution to journalArticlepeer-review

Standard

Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study. / Ó Hartaigh, Bríain; Bosch, Jos A.; Thomas, G. Neil; Lord, Janet M.; Pilz, Stefan; Loerbroks, Adrian; Kleber, Marcus E.; Grammer, Tanja B.; Fischer, Joachim E.; Boehm, Bernhard O.; März, Winfried.

In: Atherosclerosis, Vol. 224, No. 1, 01.09.2012, p. 161-169.

Research output: Contribution to journalArticlepeer-review

Harvard

Ó Hartaigh, B, Bosch, JA, Thomas, GN, Lord, JM, Pilz, S, Loerbroks, A, Kleber, ME, Grammer, TB, Fischer, JE, Boehm, BO & März, W 2012, 'Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study', Atherosclerosis, vol. 224, no. 1, pp. 161-169. https://doi.org/10.1016/j.atherosclerosis.2012.04.012

APA

Ó Hartaigh, B., Bosch, J. A., Thomas, G. N., Lord, J. M., Pilz, S., Loerbroks, A., Kleber, M. E., Grammer, T. B., Fischer, J. E., Boehm, B. O., & März, W. (2012). Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study. Atherosclerosis, 224(1), 161-169. https://doi.org/10.1016/j.atherosclerosis.2012.04.012

Vancouver

Author

Ó Hartaigh, Bríain ; Bosch, Jos A. ; Thomas, G. Neil ; Lord, Janet M. ; Pilz, Stefan ; Loerbroks, Adrian ; Kleber, Marcus E. ; Grammer, Tanja B. ; Fischer, Joachim E. ; Boehm, Bernhard O. ; März, Winfried. / Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study. In: Atherosclerosis. 2012 ; Vol. 224, No. 1. pp. 161-169.

Bibtex

@article{825ea077665943bd96f596132076bfc2,
title = "Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study",
abstract = "ObjectiveWhite blood cells are known to predict cardiovascular mortality, but form a highly heterogeneous population. It is therefore possible that specific subtypes disproportionally contribute to the prediction of cardiovascular outcomes. Therefore, we compared leukocyte subsets alone and in conjunction with an established inflammatory marker, C-reactive protein, for predicting death due to cardiovascular disease in a high-risk population.MethodsPatients, 3316, (mean [SD] age, 62 [10] years) scheduled for coronary angiography were prospectively followed up. Neutrophil, monocyte and lymphocyte counts were determined. Neutrophil and monocyte subsets were further analysed on the basis of surface expression of CD11b, CD18, CD31, CD40 and CD58. Lymphocytes were further subdivided into CD3, CD4, CD8, and CD19 subsets. The association between each marker and subsequent cardiovascular mortality was assessed using multivariable Cox regression models.ResultsDuring a median follow-up period of 7.8 years, 745 (22.5%) patients died, of which 484 were due to cardiovascular events. After entering conventional risk factors and removing patients with a current infection, neutrophil count (HR [95% CI] = 1.90 [1.39, 2.60], P < 0.001) and the neutrophil/lymphocyte ratio (HR [95% CI] = 1.68 [1.24, 2.27], P = 0.003) emerged as independent predictors of cardiovascular mortality. After mutual adjustment, neutrophil count (HR [95% CI] = 1.87 [1.35, 2.50], P < 0.001) out-performed C-reactive protein (HR [95% CI] 1.32 [0.99, 1.78], P = 0.06) as a predictor of cardiovascular mortality.ConclusionsDue to its predictive potential and inexpensive determination, assessment of high neutrophil counts may represent an important marker, possibly improving cardiovascular mortality risk prediction.",
keywords = "White blood cell, Cardiovascular disease, Neutrophil, C-reactive protein",
author = "{{\'O} Hartaigh}, Br{\'i}ain and Bosch, {Jos A.} and Thomas, {G. Neil} and Lord, {Janet M.} and Stefan Pilz and Adrian Loerbroks and Kleber, {Marcus E.} and Grammer, {Tanja B.} and Fischer, {Joachim E.} and Boehm, {Bernhard O.} and Winfried M{\"a}rz",
year = "2012",
month = sep,
day = "1",
doi = "10.1016/j.atherosclerosis.2012.04.012",
language = "English",
volume = "224",
pages = "161--169",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study

AU - Ó Hartaigh, Bríain

AU - Bosch, Jos A.

AU - Thomas, G. Neil

AU - Lord, Janet M.

AU - Pilz, Stefan

AU - Loerbroks, Adrian

AU - Kleber, Marcus E.

AU - Grammer, Tanja B.

AU - Fischer, Joachim E.

AU - Boehm, Bernhard O.

AU - März, Winfried

PY - 2012/9/1

Y1 - 2012/9/1

N2 - ObjectiveWhite blood cells are known to predict cardiovascular mortality, but form a highly heterogeneous population. It is therefore possible that specific subtypes disproportionally contribute to the prediction of cardiovascular outcomes. Therefore, we compared leukocyte subsets alone and in conjunction with an established inflammatory marker, C-reactive protein, for predicting death due to cardiovascular disease in a high-risk population.MethodsPatients, 3316, (mean [SD] age, 62 [10] years) scheduled for coronary angiography were prospectively followed up. Neutrophil, monocyte and lymphocyte counts were determined. Neutrophil and monocyte subsets were further analysed on the basis of surface expression of CD11b, CD18, CD31, CD40 and CD58. Lymphocytes were further subdivided into CD3, CD4, CD8, and CD19 subsets. The association between each marker and subsequent cardiovascular mortality was assessed using multivariable Cox regression models.ResultsDuring a median follow-up period of 7.8 years, 745 (22.5%) patients died, of which 484 were due to cardiovascular events. After entering conventional risk factors and removing patients with a current infection, neutrophil count (HR [95% CI] = 1.90 [1.39, 2.60], P < 0.001) and the neutrophil/lymphocyte ratio (HR [95% CI] = 1.68 [1.24, 2.27], P = 0.003) emerged as independent predictors of cardiovascular mortality. After mutual adjustment, neutrophil count (HR [95% CI] = 1.87 [1.35, 2.50], P < 0.001) out-performed C-reactive protein (HR [95% CI] 1.32 [0.99, 1.78], P = 0.06) as a predictor of cardiovascular mortality.ConclusionsDue to its predictive potential and inexpensive determination, assessment of high neutrophil counts may represent an important marker, possibly improving cardiovascular mortality risk prediction.

AB - ObjectiveWhite blood cells are known to predict cardiovascular mortality, but form a highly heterogeneous population. It is therefore possible that specific subtypes disproportionally contribute to the prediction of cardiovascular outcomes. Therefore, we compared leukocyte subsets alone and in conjunction with an established inflammatory marker, C-reactive protein, for predicting death due to cardiovascular disease in a high-risk population.MethodsPatients, 3316, (mean [SD] age, 62 [10] years) scheduled for coronary angiography were prospectively followed up. Neutrophil, monocyte and lymphocyte counts were determined. Neutrophil and monocyte subsets were further analysed on the basis of surface expression of CD11b, CD18, CD31, CD40 and CD58. Lymphocytes were further subdivided into CD3, CD4, CD8, and CD19 subsets. The association between each marker and subsequent cardiovascular mortality was assessed using multivariable Cox regression models.ResultsDuring a median follow-up period of 7.8 years, 745 (22.5%) patients died, of which 484 were due to cardiovascular events. After entering conventional risk factors and removing patients with a current infection, neutrophil count (HR [95% CI] = 1.90 [1.39, 2.60], P < 0.001) and the neutrophil/lymphocyte ratio (HR [95% CI] = 1.68 [1.24, 2.27], P = 0.003) emerged as independent predictors of cardiovascular mortality. After mutual adjustment, neutrophil count (HR [95% CI] = 1.87 [1.35, 2.50], P < 0.001) out-performed C-reactive protein (HR [95% CI] 1.32 [0.99, 1.78], P = 0.06) as a predictor of cardiovascular mortality.ConclusionsDue to its predictive potential and inexpensive determination, assessment of high neutrophil counts may represent an important marker, possibly improving cardiovascular mortality risk prediction.

KW - White blood cell

KW - Cardiovascular disease

KW - Neutrophil

KW - C-reactive protein

U2 - 10.1016/j.atherosclerosis.2012.04.012

DO - 10.1016/j.atherosclerosis.2012.04.012

M3 - Article

C2 - 22809446

VL - 224

SP - 161

EP - 169

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -