Abstract
The conversion of 2,2-bipyridine (bpy) to 4,4'-disubstituted derivatives is commonly achieved by a route involving preparation of the NAP-dioxide and subsequent nitration with HNO3/H2SO4. The yields in the latter reaction are of the order of 50% and we now show that a competing ring oxidation process leads to the formation of 4-nitropicolinic acid. The solid state structure of the monohydrate of 4-nitropicolinic acid is reported, which exhibits a series of interesting packing motifs arising from hydrogen bonding networks.
Original language | English |
---|---|
Pages (from-to) | 299-303 |
Number of pages | 5 |
Journal | Supramolecular Chemistry |
Volume | 18 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2006 |
Keywords
- nitration
- 2,2-bipyridine
- oxidation
- crystal structure