Where did all the bpy go? - Synthesis, crystal and molecular structure of 4-nitropicolinic acid monohydrate
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Colleges, School and Institutes
The conversion of 2,2-bipyridine (bpy) to 4,4'-disubstituted derivatives is commonly achieved by a route involving preparation of the NAP-dioxide and subsequent nitration with HNO3/H2SO4. The yields in the latter reaction are of the order of 50% and we now show that a competing ring oxidation process leads to the formation of 4-nitropicolinic acid. The solid state structure of the monohydrate of 4-nitropicolinic acid is reported, which exhibits a series of interesting packing motifs arising from hydrogen bonding networks.
|Number of pages||5|
|Publication status||Published - 1 Apr 2006|
- nitration, 2,2-bipyridine, oxidation, crystal structure