What can rheumatologists learn from translational cancer therapy?

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What can rheumatologists learn from translational cancer therapy? / Sherlock, Jonathan P; Filer, Andrew D; Isaacs, John D; Buckley, Christopher D.

In: Arthritis Research & Therapy, Vol. 15, No. 114, 01.05.2013.

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@article{175ca2471b104a55993f1c0aaa4cb6b5,
title = "What can rheumatologists learn from translational cancer therapy?",
abstract = "It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of these processes has revealed profound similarities in the specific molecules involved in persistence of inflammation and in both the primary induction of neoplastic processes and in specification of the preferred anatomic sites of metastatic spread. The therapeutic importance of these findings is underscored by the remarkable success in the treatment of autoimmune pathology using medications initially developed for use in oncology and this arena is one of considerable therapeutic promise for rheumatologists.",
keywords = "Autoimmune Diseases, Humans, Inflammation, Neoplasms, Rheumatology, Translational Medical Research",
author = "Sherlock, {Jonathan P} and Filer, {Andrew D} and Isaacs, {John D} and Buckley, {Christopher D}",
year = "2013",
month = may,
day = "1",
doi = "10.1186/ar4203",
language = "English",
volume = "15",
journal = "Arthritis Research & Therapy",
issn = "1478-6354",
publisher = "Springer",
number = "114",

}

RIS

TY - JOUR

T1 - What can rheumatologists learn from translational cancer therapy?

AU - Sherlock, Jonathan P

AU - Filer, Andrew D

AU - Isaacs, John D

AU - Buckley, Christopher D

PY - 2013/5/1

Y1 - 2013/5/1

N2 - It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of these processes has revealed profound similarities in the specific molecules involved in persistence of inflammation and in both the primary induction of neoplastic processes and in specification of the preferred anatomic sites of metastatic spread. The therapeutic importance of these findings is underscored by the remarkable success in the treatment of autoimmune pathology using medications initially developed for use in oncology and this arena is one of considerable therapeutic promise for rheumatologists.

AB - It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of these processes has revealed profound similarities in the specific molecules involved in persistence of inflammation and in both the primary induction of neoplastic processes and in specification of the preferred anatomic sites of metastatic spread. The therapeutic importance of these findings is underscored by the remarkable success in the treatment of autoimmune pathology using medications initially developed for use in oncology and this arena is one of considerable therapeutic promise for rheumatologists.

KW - Autoimmune Diseases

KW - Humans

KW - Inflammation

KW - Neoplasms

KW - Rheumatology

KW - Translational Medical Research

U2 - 10.1186/ar4203

DO - 10.1186/ar4203

M3 - Article

C2 - 23638860

VL - 15

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

SN - 1478-6354

IS - 114

ER -