Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal carcinoma treatment (ICON8): primary progression free survival analysis results from a GCIG phase 3 randomised controlled trial

Research output: Contribution to journalArticle


  • Andrew R. Clamp
  • Elizabeth C. James
  • Iain A. McNeish
  • Andrew Dean
  • Jae Weon Kim
  • Dearbhaile M. O'Donnell
  • Jane Hook
  • Christopher Coyle
  • Sarah Blagden
  • James D. Brenton
  • Raj Naik
  • Tim Perren
  • Adrian D. Cook
  • Gosala S. Gopalakrishnan
  • Hani Gabra
  • Rosemary Lord
  • Graham Dark
  • Helena M. Earl
  • Marcia Hall
  • Susana Banerjee
  • Rosalind M. Glasspool
  • Rachel Jones
  • Sarah Williams
  • Ann Marie Swart
  • Sally Stenning
  • Mahesh Parmar
  • Richard Kaplan
  • Jonathan A. Ledermann

Colleges, School and Institutes

External organisations

  • University of Manchester
  • UCL
  • Imperial College London
  • St John of God Hospital
  • Cancer Trials Ireland
  • St James' Hospital
  • Queen Alexandra Hospital
  • University of Oxford
  • Cancer Research UK Cambridge Institute
  • Queen Elizabeth Hospital, Gateshead
  • AstraZeneca
  • Clatterbridge Cancer Centre
  • Freeman Hospital
  • University of Cambridge
  • Mount Vernon Hospital
  • St. George's Healthcare National Health Service Trust
  • Beatson West Of Scotland Cancer Centre
  • Velindre Cancer Centre
  • Birmingham City Hospital
  • University of East Anglia, Norwich Medical School


Background: Carboplatin and paclitaxel administered every 3 weeks is standard-of-care first-line chemotherapy for epithelial ovarian cancer. The Japanese JGOG3016 trial showed a significant improvement in progression-free and overall survival with dose-dense weekly paclitaxel and 3-weekly carboplatin. In this study, we aimed to compare efficacy and safety of two dose-dense weekly regimens to standard 3-weekly chemotherapy in a predominantly European population with epithelial ovarian cancer. Methods: In this phase 3 trial, women with newly diagnosed International Federation of Gynecology and Obstetrics stage IC–IV epithelial ovarian cancer were randomly assigned to group 1 (carboplatin area under the curve [AUC]5 or AUC6 and 175 mg/m2 paclitaxel every 3 weeks), group 2 (carboplatin AUC5 or AUC6 every 3 weeks and 80 mg/m2 paclitaxel weekly), or group 3 (carboplatin AUC2 and 80 mg/m2 paclitaxel weekly). Written informed consent was provided by all women who entered the trial. The protocol had the appropriate national research ethics committee approval for the countries where the study was conducted. Patients entered the trial after immediate primary surgery, or before neoadjuvant chemotherapy with subsequent planned delayed primary surgery. The trial coprimary outcomes were progression-free survival and overall survival. Data analyses were done on an intention-to-treat basis, and were powered to detect a hazard ratio of 0·75 in progression-free survival. The main comparisons were between the control group (group 1) and each of the weekly research groups (groups 2 and 3). Findings: Between June 6, 2011, and Nov 28, 2014, 1566 women were randomly assigned to treatment. 72% (365), completed six protocol-defined treatment cycles in group 1, 60% (305) in group 2, and 63% (322) in group 3, although 90% (454), 89% (454), and 85% (437) completed six platinum-based chemotherapy cycles, respectively. Paclitaxel dose intensification was achieved with weekly treatment (median total paclitaxel dose 1010 mg/m2 in group 1; 1233 mg/m2 in group 2; 1274 mg/m2 in group 3). By February, 2017, 1018 (65%) patients had experienced disease progression. No significant progression-free survival increase was observed with either weekly regimen (restricted mean survival time 24·4 months [97·5% CI 23·0–26·0] in group 1, 24·9 months [24·0–25·9] in group 2, 25·3 months [23·9–26·9] in group 3; median progression-free survival 17·7 months [IQR 10·6–not reached] in group 1, 20·8 months [11·9–59·0] in group 2, 21·0 months [12·0–54·0] in group 3; log-rank p=0·35 for group 2 vs group 1; group 3 vs 1 p=0·51). Although grade 3 or 4 toxic effects increased with weekly treatment, these effects were predominantly uncomplicated. Febrile neutropenia and sensory neuropathy incidences were similar across groups. Interpretation: Weekly dose-dense chemotherapy can be delivered successfully as first-line treatment for epithelial ovarian cancer but does not significantly improve progression-free survival compared with standard 3-weekly chemotherapy in predominantly European populations. Funding: Cancer Research UK, Medical Research Council, Health Research Board in Ireland, Irish Cancer Society, Cancer Australia.


Original languageEnglish
Pages (from-to)2084-2095
Number of pages12
JournalThe Lancet
Issue number10214
Publication statusPublished - 7 Dec 2019

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