Vitamin D, the placenta and early pregnancy: effects on trophoblast function

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Vitamin D, the placenta and early pregnancy : effects on trophoblast function. / Ganguly, Ankana; Tamblyn, Jennifer Ann; Finn-Sell, Sarah; Chan, Shiao-Yng; Westwood, Melissa; Gupta, Janesh; Kilby, Mark; Gross, Stephane R; Hewison, Martin.

In: Journal of Endocrinology, 06.11.2017.

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@article{5e7067a2e01c4a80bb751d5e4e07e40f,
title = "Vitamin D, the placenta and early pregnancy: effects on trophoblast function",
abstract = "Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH)2D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH)2D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH)2D remains unclear, but is likely to involve localised tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH)2D. We have previously described immunomodulatory responses to 1,25(OH)2D by diverse populations of VDR-expressing cells within the decidua. The aim of the current review is to detail the role of vitamin D in pregnancy from a trophoblast perspective, with particular emphasis on the potential role of 1,25(OH)2D as a regulator of trophoblast invasion in early pregnancy. Vitamin D-deficiency is common in pregnant women, and a wide range of studies have linked low vitamin D status to adverse events in pregnancy. To date most of these studies have focused on adverse events later in pregnancy, but the current review will explore the potential impact of vitamin D on early pregnancy, and how this may influence implantation and miscarriage.",
keywords = "Journal Article",
author = "Ankana Ganguly and Tamblyn, {Jennifer Ann} and Sarah Finn-Sell and Shiao-Yng Chan and Melissa Westwood and Janesh Gupta and Mark Kilby and Gross, {Stephane R} and Martin Hewison",
year = "2017",
month = nov,
day = "6",
doi = "10.1530/JOE-17-0491",
language = "English",
journal = "Journal of Endocrinology",
issn = "0022-0795",
publisher = "BioScientifica",

}

RIS

TY - JOUR

T1 - Vitamin D, the placenta and early pregnancy

T2 - effects on trophoblast function

AU - Ganguly, Ankana

AU - Tamblyn, Jennifer Ann

AU - Finn-Sell, Sarah

AU - Chan, Shiao-Yng

AU - Westwood, Melissa

AU - Gupta, Janesh

AU - Kilby, Mark

AU - Gross, Stephane R

AU - Hewison, Martin

PY - 2017/11/6

Y1 - 2017/11/6

N2 - Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH)2D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH)2D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH)2D remains unclear, but is likely to involve localised tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH)2D. We have previously described immunomodulatory responses to 1,25(OH)2D by diverse populations of VDR-expressing cells within the decidua. The aim of the current review is to detail the role of vitamin D in pregnancy from a trophoblast perspective, with particular emphasis on the potential role of 1,25(OH)2D as a regulator of trophoblast invasion in early pregnancy. Vitamin D-deficiency is common in pregnant women, and a wide range of studies have linked low vitamin D status to adverse events in pregnancy. To date most of these studies have focused on adverse events later in pregnancy, but the current review will explore the potential impact of vitamin D on early pregnancy, and how this may influence implantation and miscarriage.

AB - Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH)2D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH)2D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH)2D remains unclear, but is likely to involve localised tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH)2D. We have previously described immunomodulatory responses to 1,25(OH)2D by diverse populations of VDR-expressing cells within the decidua. The aim of the current review is to detail the role of vitamin D in pregnancy from a trophoblast perspective, with particular emphasis on the potential role of 1,25(OH)2D as a regulator of trophoblast invasion in early pregnancy. Vitamin D-deficiency is common in pregnant women, and a wide range of studies have linked low vitamin D status to adverse events in pregnancy. To date most of these studies have focused on adverse events later in pregnancy, but the current review will explore the potential impact of vitamin D on early pregnancy, and how this may influence implantation and miscarriage.

KW - Journal Article

U2 - 10.1530/JOE-17-0491

DO - 10.1530/JOE-17-0491

M3 - Article

C2 - 29109081

JO - Journal of Endocrinology

JF - Journal of Endocrinology

SN - 0022-0795

ER -