Vitamin D, the placenta and early pregnancy: effects on trophoblast function

Research output: Contribution to journalArticle

Authors

  • Ankana Ganguly
  • Sarah Finn-Sell
  • Shiao-Yng Chan
  • Melissa Westwood
  • Stephane R Gross

External organisations

  • A Ganguly, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.
  • J Tamblyn, Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.
  • University of Manchester
  • S Chan, Department of Obstetrics and Gynaecology, National University Singapore Yong Loo Lin School of Medicine, Singapore, Singapore.
  • J Gupta, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.
  • M Kilby, Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.
  • Aston University
  • M Hewison, Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland m.hewison@bham.ac.uk.

Abstract

Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH)2D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH)2D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH)2D remains unclear, but is likely to involve localised tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH)2D. We have previously described immunomodulatory responses to 1,25(OH)2D by diverse populations of VDR-expressing cells within the decidua. The aim of the current review is to detail the role of vitamin D in pregnancy from a trophoblast perspective, with particular emphasis on the potential role of 1,25(OH)2D as a regulator of trophoblast invasion in early pregnancy. Vitamin D-deficiency is common in pregnant women, and a wide range of studies have linked low vitamin D status to adverse events in pregnancy. To date most of these studies have focused on adverse events later in pregnancy, but the current review will explore the potential impact of vitamin D on early pregnancy, and how this may influence implantation and miscarriage.

Details

Original languageEnglish
JournalJournal of Endocrinology
Early online date6 Nov 2017
Publication statusE-pub ahead of print - 6 Nov 2017

Keywords

  • Journal Article